Volume 5.15 | Apr 18

Cord Blood News 5.15 April 18, 2013
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
CD34+ Expansion with Delta-1 and HOXB4 Promotes Rapid Engraftment and Transfusion Independence in a Macaca nemestrina Cord Blood Transplant Model
Researchers explored in a macaque cord blood transplant model expansion and engraftment kinetics of cells expanded with the combination of HOXB4 and Delta-1. [Mol Ther] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Fev Regulates Hematopoietic Stem Cell Development via ERK Signaling
The authors showed that Fev, an ETS transcription factor, is a pivotal regulator of hematopoietic stem cell (HSC) development in vertebrates. Experiments performed with purified cord blood showed that fev is expressed and functions in primitive HSCs in humans, indicating its conserved role in higher vertebrates. [Blood] Abstract

Human Placenta-Derived Mesenchymal Stem Cells Promote Hepatic Regeneration in CCl4-Injured Rat Liver Model via Increased Autophagic Mechanism
Scientists investigated autophagy’s activation in carbon tetrachloride (CCl4)-injured rat liver following transplantation with chorionic plate-derived mesenchymal stem cells isolated from placenta. [Stem Cells] Abstract

Shear Stress Activates Extracellular Signal-Regulated Kinase 1/2 via the Angiotensin II Type 1 Receptor
Whether the angiotensin II AT1 receptor transduces shear stress in endothelial cells is unknown. Researchers exposed human umbilical cord endothelial cells to a shear stress of 0 (control) or 15 dyn/cm2 for 5 or 10 min. [FASEB J] Abstract

Microvesicles Derived from Human Umbilical Cord Wharton’s Jelly Mesenchymal Stem Cells Attenuate Bladder Tumor Cell Growth In Vitro and In Vivo
Researchers evaluated whether microvesicles derived from human umbilical cord Wharton’s jelly mesenchymal stem cells may inhibit bladder tumor T24 cells growth using cell culture and the BALB/c nu/nu mice xenograft model. [PLoS One] Full Article

Characteristics of Chronic GvHD after Cord Blood Transplantation
Investigators used traditional criteria and National Institutes of Health criteria prospectively to evaluate chronic GvHD in a cohort of 87 adult and pediatric recipients of single or double unrelated cord blood transplantation for treatment of hematologic malignancies. [Bone Marrow Transplant] Abstract

Differential MicroRNA Signature of Human Mesenchymal Stem Cells from Different Sources Reveals an “Environmental-Niche Memory” for Bone Marrow Stem Cells
To identify microRNAs (miRNAs) that can discriminate among mesenchymal stem cells (MSCs), researchers performed a whole-genome comparative miRNA expression profiling analysis on adipose, bone marrow and cord blood derived MSCs, all three considered among the most promising in the field of regenerative medicine. [Exp Cell Res] Abstract

Analysis of Oxygen-Dependent Cytokine Expression in Human Mesenchymal Stem Cells Derived from Umbilical Cord
Investigators analyzed the oxygen-dependent cytokine expression of human mesenchymal stem cells derived from umbilical cord and attempted to link the results to the proliferation and differentiation capacities of these cells. [Cell Tissue Res] Abstract

Maturation of Toll-Like Receptor 1-4 Responsiveness during Early Life
In order to achieve a more complete understanding of the ontogeny of immune system during the first years of life, researchers investigated age-matched toll-like receptor 1-4 responsiveness at several time points up to the age of two years. Mononuclear cells were isolated from cord blood and peripheral blood from infants at 6, 12, and 24 months of age, and from 50 adults. [Early Hum Dev] Abstract

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REVIEWS
Umbilical Cord Blood: An Evolving Stem Cell Source for Sickle Cell Disease Transplants
Allogeneic hematopoietic stem cell transplantation has proven benefit in controlling sickle cell disease-related vasculopathy and organ damage. Myeloablative matched sibling donor cord transplants have excellent outcomes in sickle cell disease. [Stem Cells Transl Med] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

11th Annual International Cord Blood Symposium | San Francisco
INDUSTRY NEWS

Cell Therapy Catapult & the UK Stem Cell Foundation Agree to Collaborate: Working Together on Next-Generation Medicines for Patient Benefit
The Cell Therapy Catapult and the UK Stem Cell Foundation announced that they will be working together to progress promising stem cell-based therapies in the UK. The two organizations, which have entered into a memorandum of understanding to cover their co-operation, are both focused on translational activities, moving potential therapeutic approaches on from early-stage research to the later stages of development. [Cell Therapy Catapult] Press Release

Putin Watches as UMCG Signs Cooperation Agreement to Set Up Stem Cell Institute in Russia
President Vladimir Putin of the Russian Federation and Dutch Prime Minister Mark Rutte watched as Folkert Kuipers, Dean of the Faculty of Medical Sciences and the Supervisory Board of the University Medical Center Groningen (UMCG), signed a cooperation agreement aimed at establishing a stem cell institute in Skolkovo, Russia. President Edward Crawley and director Nikolai Yankovsky signed the agreement on behalf of the Russian partners, the Skolkovo Institute of Science and Technology and the Vavilov Institute of General Genetics, respectively. [University Medical Center Groningen] Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW CReATe Cord Blood Bank: Novel Opportunities in Perinatal Stem Cell Banking
May 7, 2013
Toronto, Ontario

NEW ICCSCE 2013: International Conference on Cell and Stem Cell Engineering
September 26-27, 2013
Rome, Italy

Visit our events page to see a complete list of events in the cord blood community.

JOB OPPORTUNITIES

Early Stage Researcher PhD Posts – DECIDE ITN (The University of Birmingham)

Cord Blood Laboratory Manager (Puget Sound Blood Center)

Medical Technologist I – Confocal Microscopy & Live Cell Imaging Specialist (King Abdullah International Medical Research Center)

Postdoctoral Positions (Stony Brook University)

Postdoctoral Position – Stem Cell Biology (St. Jude Children’s Research Hospital)

Postdoctoral Research Associate (Washington State University)

Technology Manager (GE Healthcare)

Development/Senior Development Scientist (GE Healthcare)


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