Volume 5.17 | May 2

Cord Blood News 5.17 May 2, 2013
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Human Umbilical Cord Blood Stem Cells for Spinal Cord Injury: Early Transplantation Results in Better Local Angiogenesis
Researchers explored the repair mechanism after the transplantation of CD34+ human umbilical cord blood cells in traumatic spinal cord injury in rats. [Regen Med] Abstract

Learn About the CFU Assay as an In Vitro Tool for Predicting In Vivo Cytopenia Earlier in Drug Development - Free White Paper
PUBLICATIONS (Ranked by impact factor of the journal)
Evidence for CXCL16 as a Potent Angiogenic Mediator and Endothelial Progenitor Cell Chemotactic Factor
Scientists examined the possibility that CXCL16 recruits endothelial cells to developing neovasculature in rheumatoid arthritis synovium. Human dermal microvascular endothelial cells and endothelial progenitor cells from human cord blood were also examined for CXCR6 expression by immunofluorescence and signaling activity for CXCL16. [Arthritis Rheum] Abstract

Methods of Freezing Cord Blood Hematopoietic Stem Cells
The authors compared the effect of two-step cryopreservation and controlled-rate freezing method on the post-thaw quality of cord blood (CB) and evaluated the post-thaw quality of hematopoietic stem cell fractions isolated from CB with various methods and frozen with controlled-rate freezing method. [Transfusion] Abstract

The Characteristic Expression Pattern of BMI-1 and SALL4 Genes in Placenta Tissue and Cord Blood
SALL4 and BMI-1 are important factors in hematopoiesis. Placental tissue (PT) and umbilical cord blood (CB) are rich in hematopoietic stem/progenitor cells, but their SALL4 and BMI-1 expression levels remain unknown. Real-time PCR was used to determine the expression level of these genes in PT and CB from ten cases, and ten healthy donors were used as control. [Stem Cell Res Ther] Abstract | Full Article

Exosomes Released by Human Umbilical Cord Mesenchymal Stem Cells Protect against Cisplatin-Induced Renal Oxidative Stress and Apoptosis In Vivo and In Vitro
Researchers focused on the protective effect of exosomes derived from human umbilical cord mesenchymal stem cells on cisplatin-induced nephrotoxicity in vivo and in vitro. [Stem Cell Res Ther] Abstract | Full Article

Comparative Evaluation of In Vivo Osteogenic Differentiation of Fetal and Adult Mesenchymal Stem Cell in Rat Critical-Sized Femoral Defect Model
Scientists compared the in vivo osteogenic potential of adult mesenchymal stem cells (MSCs) from adipose tissue and bone marrow with fetal MSCs from umbilical cord and umbilical cord blood by using a rat critical-sized femoral defect model. [Cell Tissue Res] Abstract

Conditioned Medium from Human Amniotic Epithelial Cells May Induce the Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells into Dopaminergic Neuron-Like Cells
Dopaminergic neuron therapy has been established as a new clinical tool for treating Parkinson's disease. Prior to cell transplantation, there are two primary issues that must be resolved: one is the appropriate seed cell origin, and the other is the efficient inducing technique. Human umbilical cord blood-derived mesenchymal stem cells were used as the available seed cells, and conditioned medium from human amniotic epithelial cells was used as the inducing reagent. [J Neurosci Res] Abstract

Umbilical Cord Blood Cells Regulate Endogenous Neural Stem Cell Proliferation via Hedgehog Signaling in Hypoxic-Ischemic Neonatal Rats
Investigators examined whether umbilical cord blood mononuclear cells promote neural stem cell proliferation via the Sonic hedgehog signaling pathway. [Brain Res] Abstract

Role of CD271 Enrichment in the Isolation of Mesenchymal Stromal Cells from Umbilical Cord Blood
Isolation of mesenchymal stromal cells (MSCs) from the umbilical cord blood (UCB) has a success rate of 25% and is frequently contaminated by osteoclast-like cells. CD271 is a well-known marker for the enrichment of bone marrow MSCs. Researchers assessed the effect of CD271 isolation on the isolation rate of MSCs from UCB. [Cell Biol Int] Abstract

FREE Technical Resource: Atlas of Hematopoietic Colonies from Cord Blood. Request your copy.
REVIEWS

Pluripotent Possibilities: Human Umbilical Cord Blood Cell Treatment after Neonatal Brain Injury
The pluripotent capacity of stem cells from the human umbilical cord blood provides simultaneous targeting of multiple neuropathologic events initiated by a hypoxic-ischemic insult. Their high regenerative potential and naïve immunologic phenotype makes them a preferable choice for transplantation. [Pediatr Neurol] Abstract

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INDUSTRY NEWS
ViaCord® to Advance Cord Blood Stem Cell Therapy Research through Collaboration with the Center for International Blood and Marrow Transplant Research®
ViaCord, PerkinElmer's family cord blood and tissue preservation business, is collaborating with the Center for International Blood and Marrow Transplant Research to collect, maintain and publish research from ViaCord's cord blood stem cell transplants. This collaboration will expand knowledge of cord blood-derived stem cell applications throughout the medical and research community. [PerkinElmer Inc.] Press Release

Cryo-Save Facilitates the First Transplantation in Spain to Treat Blackfan-Diamond Anemia Thanks to the Cost-Free Donation Program
A four-year-old boy was treated for Blackfan-Diamond anemia with a stem cell transplant from his sister's umbilical cord blood. The transplant was performed at the Hospital del Niño Jesús in Madrid, one of the most important pediatric hospitals in Spain. The transplantation was successful, and the child is expected to make a normal recovery. [Cryo-Save AG] Press Release

STEMCELL Technologies Inc. Obtains License from iPS Academia Japan for Induced Pluripotent Stem Cell Technologies
STEMCELL Technologies Inc. has signed an agreement to license iPS Academia Japan’s induced pluripotent stem cell (iPS cell) technologies. This agreement will enable STEMCELL Technologies to develop media that are optimized for cellular reprogramming, further expanding its extensive portfolio of products designed to facilitate cutting-edge pluripotent stem cell research. [STEMCELL Technologies Inc.] Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS
NEW Cold Spring Harbor Laboratory: Stem Cell Biology
September 24-28, 2013
Cold Spring Harbor, United States

Visit our events page to see a complete list of events in the cord blood community.
JOB OPPORTUNITIES

NEW Postdoctoral Research Scientist (Anthony Nolan)

Research Associate (University of Texas Southwestern Medical Center at Dallas)

Postdoctoral Position - Novel Gene Discovery (St. Jude Children’s Research Hospital)

Cord Blood Laboratory Manager (Puget Sound Blood Center)

Postdoctoral Position - Stem Cell Biology (St. Jude Children's Research Hospital)

Technology Manager (GE Healthcare)

Development/Senior Development Scientist (GE Healthcare)


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