Volume 5.25 | Jun 27

Cord Blood News 5.25 June 27, 2013
Cord Blood News
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LIN28B-Mediated Expression of Fetal Hemoglobin and Production of Fetal-Like Erythrocytes from Adult Human Erythroblasts Ex Vivo
To explore the effects of LIN28B in human erythroid cell development, lentiviral transduction was utilized to knockdown LIN28B expression in erythroblasts cultured from human umbilical cord CD34+ cells. [Blood] Abstract
Technical Bulletin: Assays For Cord Blood
PUBLICATIONS (Ranked by impact factor of the journal)
Alternative Xeno-Free Biomaterials Derived from Human Umbilical Cord for the Self-Renewal Ex Vivo Expansion of Mesenchymal Stem Cells
Researchers investigated whether human umbilical cord extract could serve as a serum replacement and whether collagen purified from umbilical cord could act as an extracellular matrix for the in vitro culture of mesenchymal stem cells derived from human umbilical cord. [Stem Cells Dev] Abstract

IFN-Gamma Stimulated Human Umbilical-Tissue Derived Cells Potently Suppress NK Activation and Resist NK Mediated Cytotoxicity In Vitro
Scientists evaluated in vitro Natural Killer (NK) cell interactions with human umbilical tissue-derived cells (hUTC) and compared it to human mesenchymal stem cells. Their investigations showed that hUTC suppress NK activation, through prostaglandin-E2 secretion in a contact independent manner. [Stem Cells Dev] Abstract

Inhibitory Effect of Glyceollins on Vasculogenesis through Suppression of Endothelial Progenitor Cell Function
Investigators aimed to determine the effect of glyceollin treatment on endothelial progenitor cells (EPCs) during early tumor vasculogenesis. They found that glyceollin treatment significantly decreased the number of EPC colony-forming units in human cord blood-derived AC133+ cells and mouse bone-marrow-derived c-Kit+/Sca-1+/Lin cells. [Mol Nutr Food Res] Abstract

Maturation of CD4+ Regulatory T Lymphocytes and of Cytokine Secretions in Infants Born Prematurely
The proportions of CD4+ regulatory T lymphocyte cells, their phenotypic characteristics, and the mitogen-induced cytokine productions by peripheral blood mononuclear cells were analyz ed in 26 very-preterm infants from 2 to 16 months of age, and compared to results obtained for 17 cord blood mononuclear cells from very-preterm infants, 12 from term infants and to blood samples from 40 adults. [J Clin Immunol] Abstract

Unrelated Cord Blood Transplantation for Central Nervous System Relapse in High-Risk Childhood Acute Lymphoblastic Leukemia
Scientists aimed to identify the potential benefits of unrelated cord blood transplantation in high-risk childhood acute lymphoblastic leukemia with central nervous system (CNS) relapse who has been treated on CNS-directed treatment strategies. [Ann Hematol] Abstract

Human Umbilical-Cord-Blood Mononucleated Cells Enhance the Survival of Lethally Irradiated Mice: Dosage and the Window of Time
Researchers evaluated the window of time and dose of human umbilical-cord-blood mononucleated cells necessary for successful treatment of radiation injury in mice. [J Radiat Res] Full Article

Request Your Free Wallchart: Mesenchymal Stem Cells (A Nature Reviews Molecular Cell Biology Collaboration)
Unrelated and Alternative Donor Allogeneic Stem Cell Transplant in Patients with Relapsed or Refractory Hodgkin Lymphoma: A Systematic Review
The aim of this systematic review was to determine the benefits and harms of allogeneic stem cell transplant (allo-SCT) with an unrelated donor versus related donor allo-SCT for adult patients with Hodgkin lymphoma. Alternative donor sources such as haploidentical donor cells and umbilical cord blood were also included. [Leuk Lymphoma] Abstract

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Pluristem Enters into Strategic Partnership and Licensing Agreement with Cha Bio&Diostech for the Development and Commercialization of PLX Cells for the Treatment of CLI and IC in South Korea
Pluristem Therapeutics Inc. announced that its wholly owned subsidiary, Pluristem Ltd., has entered into an exclusive out-license and strategic partnership agreement with Cha Bio&Diostech for the use of Pluristem’s PLacental eXpanded (PLX) cells for peripheral artery disease, specifically in two indications: the treatment of Critical Limb Ischemia (CLI), and Intermediate Claudication (IC) in South Korea. [Pluristem Therapeutics Inc.] Press Release

SCRM Building Wins New Laboratory Building of the Year Award
The Scottish Centre for Regenerative Medicine (SCRM) building has been named as best new laboratory building in the S-Lab Awards, which recognize laboratories for sustainability, safety and success. [MRC Centre for Regenerative Medicine] Press Release

From our sponsor: Free mouse hematopoietic progenitors wallchart. Request your copy.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Bioprocess Miniaturization: Development and Optimization
November 26, 2013
London, United Kingdom

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NEW Postdoctoral Position – Hematopoiesis & Leukemogenesis (University of Massachusetts Medical School)

Postdoctoral Positions – Stem Cell Biology and Epigenetics (University of Wisconsin-Madison)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

Postdoctoral Researcher – Basic and Translational Hemato-Oncology (Josep Carreras Leukaemia Research Institute)

Laboratory Manager – Basic and Translational Hemato-Oncology (Josep Carreras Leukaemia Research Institute)

PhD Student Position – Hematopoietic Stem Cells (Katholieke Universiteit Leuven)

Postdoctoral Researcher – Hematopoietic Stem Cells (Albert Einstein College of Medicine)

Assistant Professor – Stem Cell Transplantation (Boston Children’s Hospital/Harvard Medical School)

Postdoctoral Fellow – Stem Cell and Cancer Biology (Johns Hopkins University School of Medicine)

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