Volume 5.32 | Aug 15

Cord Blood News 5.32 August 15, 2013
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Analysis of Risk Factors Influencing Outcomes after Cord-Blood-Transplantation in Children with Juvenile Myelomonocytic Leukemia
Investigators retrospectively analyzed 110 patients with juvenile myelomonocytic leukemia, given single-unit, unrelated donor umbilical cord blood transplantation. [Blood] Abstract
Derivation of Metabolically Active Hepatocytes from Pluripotent Stem Cells - View On-Demand Webinar Now.
 
PUBLICATIONS (Ranked by impact factor of the journal)
Generation of Functional, Antigen-Specific CD8+ Human T Cells from Cord-Blood Stem Cells Using Exogenous Notch and Tetramer-TCR Signaling
Researchers showed that human umbilical cord blood-derived CD34+CD38-/low hematopoietic stem cells can be successfully differentiated into functional, antigen-specific cytotoxic CD8+ T cells without direct stromal co-culture or retroviral T cell receptor (TCR) transfection. [Stem Cells] Abstract

Alternative Donor Hematopoietic Stem Cell Transplantation for Mature Lymphoid Malignancies after Reduced-Intensity Conditioning Regimen: Similar Outcomes with Umbilical Cord Blood and Unrelated Donor Peripheral Blood
The authors studied 645 adult patients with mature lymphoid malignancies who received an allogeneic unrelated donor transplant using umbilical cord blood or mobilized peripheral blood stem cells after a reduced-intensity conditioning regimen. [Haematologica] Abstract

The Single-Nucleotide Polymorphism (GPX4c718t) in the Glutathione Peroxidase 4 Gene Influences Endothelial Cell Function: Interaction with Selenium and Fatty Acids
Human umbilical vein endothelial cells and monocytes homozygous for the T- or C-variant of the GPX4c718t single nucleotide polymorphism were assessed for monocyte-endothelial cell adhesion, expression of VCAM-1 and sensitivity to oxidative challenge. [Mol Nutr Food Res] Full Article

Adipogenic Potential in Human Mesenchymal Stem Cells Strictly Depends on Adult or Fetal Tissue Harvest
Scientists compared the adipogenic potential of mesenchymal stem cells originated from two adult sources as fat pads and bone marrow, and from four fetal sources as umbilical cord blood, Wharton’s jelly, amniotic fluid and preterm umbilical cord perivascular cells. [Int J Biochem Cell Biol] Abstract

Immunologic Recovery in Children after Alternative Donor Allogeneic Transplantation for Hematologic Malignancies: Comparison of Recipients of Partially T-Cell Depleted Peripheral Blood Stem Cells and Umbilical Cord Blood
Investigators compared immunologic recovery in children undergoing hematopoietic stem cell transplantation for hematologic malignancies receiving either T-cell depletion of peripheral blood stem cells or umbilical cord blood over a seven year period at a single institution. [Biol Blood Marrow Transplant] Abstract

Intravitreal Transplantation of Human Umbilical Cord Blood Stem Cells Protects Rats from Traumatic Optic Neuropathy
Researchers treated traumatic optic neuropathy with transplantation of human umbilical cord blood stem cells and explored how transplanted stem cells participate in the neuron repairing process. [PLoS One] Full Article

Evaluation of Potential Ionizing Irradiation Protectors and Mitigators Using Clonogenic Survival of Human Umbilical Cord Blood Hematopoietic Progenitor Cells
Scientists evaluated the use of colony formation by human umbilical cord blood hematopoietic progenitor cells for testing novel small molecule ionizing irradiation protectors and mitigators. [Exp Hematol] Abstract

The Anti-Apoptotic and Neuro-Protective Effects of Human Umbilical Cord Blood Mesenchymal Stem Cells (hUCB-MSCs) on Acute Optic Nerve Injury Is Transient
Researchers transplanted mesenchymal stem cells derived from human umbilical cord blood into the vitreous cavity of adult rats and investigated the probable capacity of anti-apoptosis and pro-neuroprotective effects on retinal ganglion cells. [Brain Res] Abstract

Intravenous Administration of Human Umbilical Cord Blood-Derived AC133+ Endothelial Progenitor Cells in Rat Stroke Model Reduces Infarct Volume: Magnetic Resonance Imaging and Histological Findings
Previous studies have indicated that stem/progenitor cells derived from human umbilical cord blood (hUCB) improve functional recovery in stroke models. Researchers examined the effect of hUCB AC133+ endothelial progenitor cells on stroke development and resolution in a middle cerebral artery occlusion rat model. [Stem Cells Transl Med] Abstract | Press Release

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REVIEWS
Beyond the Niche: Tissue-Level Coordination of Stem Cell Dynamics
The authors examine what is known about higher order mechanisms for interniche coordination in epithelial organs, whose simple geometry offers a promising entry point for understanding the regulation of niche number, distribution, and activity. They also consider the potential existence of stem cell territories and how tissue architecture may influence niche coordination. [Annu Rev Cell Dev Biol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
INDUSTRY NEWS
BioLife Solutions Expands Strategic Relationship with STEMCELL Technologies Inc.
BioLife Solutions, Inc. announced an expansion of its relationship with STEMCELL Technologies Inc. Since August 2009, STEMCELL Technologies has distributed BioLife’s biopreservation media products to the worldwide research and clinical biobanking communities. [BioLife Solutions, Inc.] Press Release

New Member Joins the BCA Coooperative
Blood Centers of America, Inc. (BCA) announced a new member has joined its ranks. Community Blood Center of the Carolinas, located in Charlotte, NC is the newest, non-equity member of the cooperative. [Blood Centers of America Inc.] Press Release

Stem Cell Society Singapore 2013 Symposium
 
POLICY NEWS
Establishing a Public Umbilical Cord Blood Stem Cell Bank for South Africa: An Enquiry into Public Acceptability
The authors enquired into the acceptability of establishing a public bank through an interview with and questionnaire completed by mothers-to-be in the antenatal clinic of a large public hospital in South Africa (SA). Initial results are positive, with 85% of the participants in favor of establishing a public umbilical cord blood stem cell bank in SA. Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

From our sponsor:
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EVENTS
NEW Harnessing New Players in Atherosclerosis to Treat Heart Disease
September 24, 2013
New York, United States

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Postdoctoral Position – Hematopoietic Stem Cells (St. Jude Children’s Research Hospital)

Postdoctoral Research Associates – Stem Cell Biology (University of Illinois at Chicago)

Assistant/Associate Researcher – Hematopoietic Stem Cells (UW Madison – Wisconsin National Primate Research Center)

Postdoctoral Researcher – Hematopoietic Stem Cell Fate Decisions (Albert Einstein College of Medicine)

Postdoctoral Position (Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III)

Postdoctoral Fellow – Stem Cell Biology (The University of Texas Medical School at Houston)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

Postdoctoral Researcher – Hematopoietic Stem Cells (Albert Einstein College of Medicine)


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