Volume 5.34 | Aug 29

Cord Blood News 5.34 August 29, 2013
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Human Umbilical Cord Blood Mesenchymal Stem Cells Reduce Colitis in Mice by Activating NOD2 Signaling to COX2
Nucleotide-binding oligomerization domain 2 (NOD2) regulates intestinal inflammation, and is also expressed by human umbilical cord blood-derived mesenchymal stem cells (MSCs), to regulate their differentiation. Researchers investigated whether NOD2 is required for the anti-inflammatory activities of MSCs in mice with colitis. [Gastroenterology] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Paracrine Exchanges of Molecular Signals between Alginate-Encapsulated Pericytes and Freely Suspended Endothelial Cells within a 3D Protein Gel
Scientists developed a system for sustained and regulated delivery of paracrine signals by encapsulating living cells of one type in alginate beads and co-suspending these cell-loaded particles along with unencapsulated cells of a second type within a 3D protein gel. This system was applied to vascular tissue engineering by placing human placental microvascular pericytes in the particulate alginate phase and human umbilical vein endothelial cells in the protein gel phase. [Biomaterials] Abstract

The Role of Shear-Induced Transforming Growth Factor-β Signaling in the Endothelium
Human umbilical vein endothelial cells exposed to shear stress were compared with cells grown under static conditions. Signaling through the transforming growth factor-β receptor ALK5 was inhibited with SB525334. Cells were examined for morphological changes and harvested for real-time polymerase chain reaction, Western blot analysis, apoptosis, proliferation, and immunocytochemistry. [Arterioscler Thromb Vasc Biol] Abstract

Therapeutic Effect of Transplanted Human Wharton’s Jelly Stem Cell-Derived Oligodendrocyte Progenitor Cells (hWJ-MSC-derived OPCs) in an Animal Model of Multiple Sclerosis
Scientists transplanted human Wharton’s jelly stem cell-derived oligodendrocyte progenitor cells into the brain ventricles of mice induced with experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis. [Mol Neurobiol] Abstract

The Clinical Relevance of Pre-Formed Anti-HLA and Anti- Major-Histocompatibility-Complex Class I–Related Chain A Antigens Antibodies after Cord Blood Transplantation in Children
Investigators explored the role of anti-HLA antibodies on clinical outcomes in 70 pediatric patients who received a single unit of HLA mismatch cord blood for hematologic malignancies, immunodeficiencies or metabolic diseases. [PLoS One] Full Article

Transplantation of Human Cord Blood Mononuclear Cells and Umbilical Cord-Derived Mesenchymal Stem Cells in Autism
Stem cell transplantation may offer a unique treatment strategy for autism due to immune and neural dysregulation observed in this disease. This non-randomized, open-label, single center Phase I/II trial investigated the safety and efficacy of combined transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in treating children with autism. [J Transl Med]
Abstract | Full Article

Isolation of c-Kit+ Human Amniotic Fluid Stem Cells from Second Trimester
Amniotic fluid-derived stem (AFS) cells have been described as an appealing source of stem cells because of their fetal, non-embryonic origin, easy access during pregnancy overcoming the ethical issues related both to the use of human embryonic cells and to the postnatal tissue biopsy with donor site morbidity, and their undemanding ability to be expanded. The authors and others have demonstrated the broad differentiation potential and they describe the established protocol they developed to obtain c-Kit+ human AFS cells, starting from second trimester amniocentesis samples. [Meth Mol Biol] Abstract

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REVIEWS
Regulatory Potential of COUP-TFs in Development: Stem/Progenitor Cells
The authors highlight the progress of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) function and its underlying mechanism in driving stem/progenitor cell self-renewal, lineage specification, differentiation, maintenance, and cell identity in diverse tissue types. [Semin Cell Dev Biol] Abstract

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INDUSTRY NEWS
Four UCLA Researchers Receive CIRM Early Translational Grants
Four prominent researchers from UCLA’s Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research have received Early Translational research awards totaling approximately $13 million from the California Institute for Regenerative Medicine (CIRM), the state stem cell agency. [University of California, Los Angeles] Press Release

Mayo Clinic to Open Stem Cell Laboratory in Phoenix
Mayo Clinic in Arizona will open its own stem cell laboratory in summer 2014. The laboratory will be initially dedicated to storing and processing stem cells used for bone marrow transplants at Mayo Clinic Hospital and Phoenix Children’s Hospital. [Mayo Foundation for Medical Education and Research] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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EVENTS
NEW 20th International Society for Cellular Therapy (ISCT) Annual Meeting 2014
April 23-26, 2014
Paris, France

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JOB OPPORTUNITIES
NEW Stem Cell Biology Researcher (The Czech Genetic Bank Ltd.)

Postdoctoral Research Scientist (Anthony Nolan, University College London)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Postdoctoral Position – Hematopoietic Stem Cells (St. Jude Children’s Research Hospital)

Postdoctoral Research Associates – Stem Cell Biology (University of Illinois at Chicago)

Postdoctoral Researcher – Hematopoietic Stem Cell Fate Decisions (Albert Einstein College of Medicine)

Postdoctoral Position (Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III)

Postdoctoral Fellow – Stem Cell Biology (The University of Texas Medical School at Houston)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

Postdoctoral Researcher – Hematopoietic Stem Cells (Albert Einstein College of Medicine)


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