Volume 5.37 | Sep 19

Cord Blood News 5.37 September 19, 2013
Cord Blood News
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Analysis of the Clonal Growth and Differentiation Dynamics of Primitive Barcoded Human Cord Blood Cells in NSG Mice
Researchers exposed CD34+ cord blood cells to a library of barcoded lentiviruses and used massively parallel sequencing to quantify the clonal distributions of lymphoid and myeloid cells subsequently detected in sequential marrow aspirates obtained from two primary NOD/SCID-IL2Rγ-/- mice, each transplanted with ~105 of these cells, and for another 6 months in six secondary recipients. [Blood] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Potential of Human Fetal Chorionic Stem Cells for the Treatment of Osteogenesis Imperfecta
Scientists showed that intra-peritoneal injection of human fetal chorionic stem cells in murine Osteogenesis Imperfecta neonates reduced fractures, increased bone ductility and bone volume, increased the numbers of hypertrophic chondrocytes, and upregulated endogenous genes involved in endochondral and intramembranous ossification. [Stem Cell Dev] Abstract

Amniotic Fluid Stem Cells from EGFP Transgenic Mice Attenuate Hyperoxia-Induced Acute Lung Injury
The in vivo therapeutic potential of amniotic fluid stem cells (AFSCs) was evaluated in a model of acute hyperoxia-induced lung injury in mice. The administration of AFSCs significantly reduced the hyperoxia-induced pulmonary inflammation, as reflected by significant reductions in lung wet/dry ratio, neutrophil counts, and the level of apoptosis, as well as reducing the levels of inflammatory cytokine (IL-1β, IL-6, and TNF-α) and early-stage fibrosis in lung tissues. [PLoS One] Full Article

Calcium Sensing Receptor Expression in Ovine Amniotic Fluid Mesenchymal Stem Cells and the Potential Role of R-568 during Osteogenic Differentiation
Researchers investigated the presence of Calcium Sensing Receptor (CaSR) in ovine Amniotic Fluid Mesenchymal Stem Cells (oAFMSCs) and then the potential role of calcimimetics in in vitro osteogenesis. oAFMSCs were isolated, characterized and analyzed to examine the possible presence of CaSR by western blotting and flow cytometry analysis. [PLoS One] Full Article

Higher Therapeutic CsA Levels Early Post Transplantation Reduces Risk of Acute GVHD and Improves Survival
Scientists studied whether early CsA trough levels were associated with the risk of acute GVHD in 337 patients after either sibling PBSC or double umbilical cord blood transplantation. [Bone Marrow Transplant] Abstract

Sauchinone from Saururus chinensis Protects Vascular Inflammation by Heme Oxygenase-1 Induction in Human Umbilical Vein Endothelial Cells
Researchers investigated the effect of sauchinone in suppressing cell adhesion molecules such as vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in high glucose stimulated human umbilical vein endothelial cells. [Phytomedicine] Abstract

Clinical Outcomes of Allogeneic Stem Cell Transplantation for Relapsed or Refractory Follicular Lymphoma: A Retrospective Analysis by the Fukuoka Blood and Marrow Transplantation Group
Researchers retrospectively analyzed the outcome of allogeneic hematopoietic stem cell transplantation in 30 patients with follicular lymphoma. There were no significant differences in the estimated 2-year overall survival rate between patients who received myeloablative conditioning and those who received reduced-intensity conditioning, and among the recipients of related bone marrow (BM)/peripheral blood stem cell, unrelated BM and umbilical cord blood. [Int J Hematol] Abstract

Human Umbilical Cord-Derived MSC Culture: The Replacement of Animal Sera with Human Cord Blood Plasma
In order to make the best of umbilical cord blood, human umbilical cord blood plasma was dialyzed to replace fetal bovine serum in culture medium. Human umbilical cord-derived mesenchymal stem cells (MSCs) were cultured in the new medium. [In Vitro Cell Dev Biol Anim] Abstract

Technical Bulletin: Assays For Cord Blood
Hematopoietic Stem Cell Niches: New Insights Inspire New Questions
With particular emphasis on cell type-specific deletion of SCL and CXCL12, the authors focus on unresolved issues on hematopoietic stem cell (HSC) niches, framed around some very recent advances and novel discoveries on the extrinsic regulation of HSC maintenance. [EMBO J] Full Article

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Adaptive Biotechnologies Receives $2.53 million Phase II SBIR to Develop Test to Identify Cancer Patients at Risk of Death by Infection after Cord Blood Transplants
Adaptive Biotechnologies announced that it received a $2.53 million Phase II Small Business Innovation Research award from the National Heart, Lung, and Blood Institute, a division of the NIH, to commercialize a test to measure the ability of a cancer patient’s adaptive immune system to fight infection after a cord blood transplant. [Adaptive Biotechnologies LLC] Press Release

Weill Cornell Medical College Receives $100 Million Gift from Joan and Sanford I. Weill and the Weill Family Foundation to Launch New Capital Campaign
Weill Cornell Medical College announced that it has received a $100 million gift from longtime benefactors Joan and Sanford I. Weill and the Weill Family Foundation to launch the Medical College’s $300 million Driving Discoveries, Changing Lives campaign dedicated to using the most advanced scientific approaches to rapidly translate research breakthroughs into innovative treatments and therapies for patients. [Weill Cornell Medical College] Press Release

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NEW Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

NEW Research Associate – Leukemia & Stem Cell Biology (King’s College London)

Postdoctoral Fellow – Differentiation of Erythrocytes and Endothelial Cells from Hemangioblast (University of Rochester)

Stem Cell Biology Researcher – Human Genetics and Stem Cell Biology (The Czech Genetic Bank Ltd.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Postdoctoral Position – Hematopoietic Stem Cells (St. Jude Children’s Research Hospital)

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