Volume 5.39 | Oct 3

Cord Blood News 5.39 October 3, 2013
Cord Blood News
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Human Umbilical Cord Blood Mononuclear Cells in a Double-Hit Model of Bronchopulmonary Dysplasia in Neonatal Mice
Researchers investigated the effect of umbilical cord blood mononuclear cells in a new double-hit mouse model of bronchopulmonary dysplasia. [PLoS One] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Development of a Xeno-Free Autologous Culture System for Endothelial Progenitor Cells Derived from Human Umbilical Cord Blood
To develop in vitro culture conditions for endothelial progenitor cells derived from human cord blood, investigators isolated extracts and collagen from umbilical cord tissue to replace their animal-derived counterparts. [PLoS One] Full Article

Stem Cell-Like Dog Placenta Cells Afford Neuroprotection against Ischemic Stroke Model via Heat Shock Protein Upregulation
Scientists investigated the dog placenta as a viable source of stem cells for stroke therapy. Immunocytochemical evaluation of phenotypic markers of dog placenta cells (DPCs) cultured in proliferation and differentiation medium revealed that DPCs expressed both stem cell and neural cell markers, respectively. [PLoS One] Full Article

Comparison of Unrelated Cord Blood Transplantation and HLA-Matched Sibling Hematopoietic Stem Cell Transplantation for Patients with Chronic Myeloid Leukemia in Advanced Stage
Investigators present a clinical comparison of unrelated cord blood transplantation and HLA-matched sibling allogeneic hematopoietic stem cell transplantation for patients with chronic myeloid leukemia in advanced stage (accelerated phase or blast crisis). [Biol Blood Marrow Transplant] Abstract

Risk Factors and Organ Involvement of Chronic GvHD in Japan
Researchers found that unrelated cord blood transplants were associated with a low incidence of extensive chronic GvHD and less frequent involvement of the oral cavity, eye, liver, lung and joints. [Bone Marrow Transpl] Abstract

The Effect of CD137-CD137 Ligand Interaction on Phospholipase C Signaling Pathway in Human Endothelial Cells
Researchers investigated whether CD137-CD137L interaction can stimulate the phospholipase C signaling pathway in human umbilical vein endothelial cells (HUVEC). The diacylglycerol and inositol trisphosphate levels in HUVEC were measured by radioenzymatic assay. [Chem Biol Interact] Abstract

Dielectric Study of the Adhesion of Mesenchymal Stem Cells from Human Umbilical Cord on a Sugarcane Biopolymer
Investigators evaluated the use of electric impedance spectroscopy to follow the adhesion of mesenchymal stem cells from Wharton’s jelly of the human umbilical cord on sugarcane biopolymers. [J Mater Sci Mater Med] Abstract

Culture of Mouse Amniotic Fluid-Derived Cells on Irradiated STO Feeders Results in the Generation of Primitive Endoderm Cell Lines Capable of Self-Renewal In Vitro
To better characterize putative progenitor cell populations present in amniotic fluid (AF), scientists used culture conditions that support self-renewal to determine if these promoted the generation of stable cell lines from AF-derived cells. [Cells Tissues Organs] Abstract

Generation of Induced Pluripotent Stem Cells with High Efficiency from Human Umbilical Cord Blood Mononuclear Cells
Researchers report generation of human induced pluripotent stem cells with great efficiency from umbilical cord blood mononuclear cells using a dox-inducible lentiviral system carrying four Yamanaka factors. [Genomics Proteomics Bioinformatics] Full Article

New Cord Banking Software Solution from STEMSOFT
Resilient and Resourceful: Genome Maintenance Strategies in Hematopoietic Stem Cells
The authors present the strategies used by hematopoietic stem cells (HSCs) to cope with the many genotoxic insults that they commonly encounter. They briefly describe the DNA-damaging insults that can affect HSC function, and the mechanisms that are employed by HSCs to prevent, survive, and repair DNA lesions. [Exp Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Stem Cell Society Singapore 2013 Symposium
Canadian Blood Services’ and The Ottawa Hospital Celebrate First Step Towards Building Canada’s First National Public Cord Blood Bank
Mothers delivering at The Ottawa Hospital’s General and Civic Campuses, will have an opportunity to donate their babies’ umbilical cord blood as part of Canadian Blood Services’ initial step in building Canada’s first national public cord blood bank. [The Ottawa Hospital] Press Release

National Cancer Institute Awards $48.6 Million Grant to MD Anderson
Broad, deep and outstanding research in cancer science, treatment and prevention have earned The University of Texas MD Anderson Cancer Center a $48.6-million, five-year grant from the National Cancer Institute and an “exceptional” ranking, the highest possible, from the National Cancer Institute’s extensive peer-review process. [The University of Texas MD Anderson Cancer Center] Press Release

New wallchart from our sponsor:
Mesenchymal Stem Cells (a Nature Reviews Molecular Cell Biology collaboration). Request your free copy.
US Government Shuts Down
The US government entered a state of suspended animation on 1 October after Congress failed to agree on a budget for the next fiscal year, causing federal agencies – including those overseeing science policy and research – to shut down indefinitely. Most government scientists were ordered to stay at home, their offices and labs closed or run by a skeleton staff of ‘essential’ workers. The National Institutes of Health and the National Science Foundation stopped processing grants, some government websites were made inaccessible and many important research programmes were left hanging, potentially putting lives at risk in the case of some disease studies. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Culture World Congress 2014
February 25-27, 2014
Munich, Germany

NEW 9th Annual World Stem Cells & Regenerative Medicine Congress 2014
May 20-22, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the cord blood community.
NEW Postdoctoral Position – Patient-Specific Stem Cell Lines: Disease Modeling, Repair and Transplantation (Columbia University)

Postdoctoral Position – Cellular and Genetic Therapies for Hemoglobinopathies (Blood Systems Research Institute)

Postdoctoral Position – Immune Recovery after Hematopoietic Stem Cell Transplantation (University of Minnesota – Twin Cities)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Research Associate – Leukemia & Stem Cell Biology (King’s College London)

Postdoctoral Fellow – Differentiation of Erythrocytes and Endothelial Cells from Hemangioblast (University of Rochester)

Stem Cell Biology Researcher – Human Genetics and Stem Cell Biology (The Czech Genetic Bank Ltd.)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Cell Research (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

Quality Control Analyst – Media (STEMCELL Technologies Inc.)

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