Volume 5.40 | Oct 10

Cord Blood News 5.40 October 10, 2013
Cord Blood News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress
Scientists showed that knockdown of hypoxia-inducible factor-2α (HIF-2α), and to a much lesser extent HIF-1α, impedes the long-term repopulating ability of human CD34+ umbilical cord blood cells. [Cell Stem Cell] Abstract
Use TeSR-E7 to generate iPS cells with high quality colony morphology for easy identification and rapid subcloning. Request your sample.
 
PUBLICATIONS (Ranked by impact factor of the journal)
Therapeutic Efficacy of Human Embryonic Stem Cell-Derived Endothelial Cells in Humanized Mouse Models Harboring a Human Immune System
Scientists examined the therapeutic potential of human embryonic stem cell-derived endothelial cells, human embryonic fibroblasts, and cord blood-derived endothelial progenitor cells in a human immune system environment. [Arterioscler Thromb Vasc Biol] Abstract

Umbilical Cord Blood Transplantation from Unrelated Donors in Patients with PH-Positive Acute Lymphoblastic Leukemia
Researchers report the outcome of 45 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia underwent myeloablative single unit cord blood transplantation from unrelated donors within the GETH/GITMO cooperative group. [Haematologica] Abstract | Full Article

Amniotic Fluid Stem Cells with Low γ-Interferon Response Showed Behavioral Improvement in Parkinsonism Rat Model
To further investigate the properties of amniotic fluid stem cells (AFSCs) for translational applications, investigators examined the cell surface expression of human leukocyte antigens of these cells and estimated the therapeutic effect of AFSCs in parkinsonian rats. [PLoS One] Full Article

Myeloablative Cord Blood Transplantation in Adults with Acute Leukemia: Comparison of Two Different Transplant Platforms
Scientists compared the clinical outcomes of adults with acute leukemia that received single-unit umbilical cord blood transplantation (UCBT) after conditioning with a busulfan/antithymocyte globulin-based regimen at or double-unit UCBT after conditioning with a total body irradiation-based regimen. [Biol Blood Marrow Transpl] Abstract

mRNAs and miRNAs Profiling of Mesenchymal Stem Cells Derived from Amniotic Fluid and Skin: The Double Face of the Coin
Researcher report not only the isolation and the traditional characterization of mesenchymal stem cells derived from amniotic fluid and skin but also a molecular characterization based on mRNAs and miRNAs profiling. [Cell Tissue Res] Abstract

Co-Transplantation of Mesenchymal Stromal Cells and Cord Blood Cells in Treatment of Diabetes
Researchers investigated whether co-transplantation of umbilical cord-derived mesenchymal stromal cells and cord blood mononuclear cells could reverse hyperglycemia in type 1 diabetic mice and aimed to determine the appropriate ratio for co-transplantation. [Cytotherapy] Abstract

Visit the Human Immunology Portal for cord blood protocols, tips and other resources
 
REVIEWS
Concise Review: Ex Vivo Expansion of Cord Blood-Derived Hematopoietic Stem and Progenitor Cells: Basic Principles, Experimental Approaches, and Impact in Regenerative Medicine
To date, umbilical cord blood transplants using ex vivo-expanded cells have already been performed for the treatment of different hematological disorders, and although results are still far from being optimal, the advances are encouraging. [Stem Cell Transl Med] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
SCIENCE NEWS
Amniotic Stem Cells Show Promise in Helping to Repair Cardiac Birth Defects
Researchers have begun testing an alternative to embryonic stem cells that could one day regenerate muscle tissue for babies with congenital heart defects. A research-in-progress report on this new approach, which uses amniotic stem cells, was presented. [Press release from EurekAlert! discussing research presented at the 2013 Clinical Congress of the American College of Surgeons, Washington DC] Press Release

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INDUSTRY NEWS
TrakCel Accelerates Stem Cell Logistics Solution Development with Welsh Government Funding
TrakCel announced it will commence trials with leading international pharmaceutical company GlaxoSmithKline in early 2014. Benefiting from an initial £100,000 from the Welsh Government SMART Cymru award for Research Development and Innovation, TrakCel has been able to swiftly develop demonstrable initial technology and present it to key players in the industry including GlaxoSmithKline. [Biotec Services International] Press Release

Geron Completes Divestiture of Stem Cell Assets
Geron Corporation announced the closing of the transaction to divest the company’s stem cell assets. Geron entered into an Asset Contribution Agreement with BioTime, Inc. and Asterias Biotherapeutics, Inc. [Geron Corporation] Press Release

From our sponsor: Free human hematopoietic progenitors wallchart. Request your copy.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes
November 3-6, 2013
San Diego, United States

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Translational Clinician-Scientist – Stem Cell Transplantation (Boston Children’s Hospital)

Postdoctoral Position – Patient-Specific Stem Cell Lines: Disease Modeling, Repair and Transplantation (Columbia University)

Postdoctoral Position – Cellular and Genetic Therapies for Hemoglobinopathies (Blood Systems Research Institute)

Postdoctoral Position – Immune Recovery after Hematopoietic Stem Cell Transplantation (University of Minnesota – Twin Cities)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Research Associate – Leukemia & Stem Cell Biology (King’s College London)

Postdoctoral Fellow – Differentiation of Erythrocytes and Endothelial Cells from Hemangioblast (University of Rochester)

Stem Cell Biology Researcher – Human Genetics and Stem Cell Biology (The Czech Genetic Bank Ltd.)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Cell Research (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

Quality Control Analyst – Media (STEMCELL Technologies Inc.)


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