Volume 5.41 | Oct 17

Cord Blood News 5.41 October 17, 2013
Cord Blood News
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Poly-l-Lysine Increases the Ex Vivo Expansion and Erythroid Differentiation of Human Hematopoietic Stem Cells, as well as Erythroid Enucleation Efficacy
Investigators employed cell culture plates coated with several concentrations of poly-l-lysine (PLL), a positively charged synthetic amino acid chain. Culture substrates that employed relatively high initial coating concentrations of PLL significantly increased the total number of hematopoietic stem cells during ex vivo expansion of CD34+ cells, as well as erythroid differentiation. [Tissue Eng Res A] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Cotransplantation of Haploidentical Hematopoietic and Umbilical Cord Mesenchymal Stem Cells for Severe Aplastic Anemia: Successful Engraftment and Mild Graft-versus-Host Disease
Researchers cotransplanted culture-expanded third-party donor-derived umbilical cord mesenchymal stromal cells in 21 young people with severe aplastic anemia undergoing haploidentical hematopoietic stem-cell transplantation without T cell depletion. [Stem Cell Res] Abstract

A Xeno-Free Culture Method that Enhances Wharton’s Jelly Mesenchymal Stromal Cell Culture Efficiency over Traditional Animal Serum-Supplemented Cultures
Scientists demonstrated for the first time that human serum from umbilical cord blood is an effective co-culture reagent for mesenchymal stromal cell (MSC) production from Wharton’s jelly MSCs. [Cytotherapy] Abstract

Human Umbilical Cord Mesenchymal Stem Cells Inhibit C6 Glioma Growth via Secretion of Dickkopf-1 (DKK1)
Researchers demonstrated that human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) inhibited C6 cell growth and modulated the cell cycle to G0/G1 phase. The expression of β-catenin and c-Myc was downregulated in C6 cells by conditioned media (CM) from hUC-MSCs, and the levels of secreted DKK1 were positively correlated with concentrations of hUCMSCs-CM. [Mol Cell Biochem] Abstract

A Comparative Study on Culture Conditions and Routine Expansion of Amniotic Fluid-Derived Mesenchymal Progenitor Cells
Scientists determined the best out of three published expansion protocols for mesenchymal progenitors in terms of self-renewal ability. Characterization was performed based on morphology, surface marker analysis, cytogenetic stability, and differentiation potential. [Fetal Diagn Ther] Abstract

Comparison of Different Methods for the Isolation of Mesenchymal Stem Cells from Umbilical Cord Matrix: Proliferation and Multilineage Differentiation as Compared to Mesenchymal Stem Cells from Umbilical Cord Blood and Bone Marrow
Investigators identified the most appropriate method of isolating human umbilical cord matrix-derived mesenchymal stem cells (UCM-MSCs) and compared morphological, phenotypic, proliferative, and differentiation characteristics of UCM-MSCs with bone marrow-derived MSCs and umbilical cord blood-derived MSCs. [Cell Biol Int] Abstract

Promoting Effects of Heparin on Ex Vivo Expansion of Megakaryocytopoiesis from Human Cord Blood CD34+ Cells
Scientists investigated the effects of heparin on ex vivo colony forming unit-megakaryocytes and megakaryocytes expansion from cord blood CD34+ cells. [Transfus Med Hemoth] Full Article

Prospective Surface Marker-Based Isolation and Expansion of Fetal Endothelial Colony-Forming Cells from Human Term Placenta
Investigators isolated clinically relevant quantities of fetal endothelial colony-forming cells (ECFCs) from human term placenta and compared them to the well-established donor-matched umbilical cord blood-derived ECFCs. [Stem Cells Transl Med] Abstract

Efficiently Expand hPSC-Derived NPCs Without Loss of Multipotency: STEMdiff™ Neural Progenitor Medium
Stem Cell Therapy to Protect and Repair the Developing Brain: A Review of Mechanisms of Action of Cord Blood and Amnion Epithelial Derived Cells
The authors explore the novel characteristics of human amnion epithelial cells and undifferentiated umbilical cord blood (UCB) cells, as well as UCB-derived endothelial progenitor cells and mesenchymal stem cells, and how immunomodulation and anti-inflammatory properties are principal mechanisms of action that are common to these cells, and which in turn may ameliorate the cerebral hypoxia and inflammation that are final pathways in the pathogenesis of perinatal brain injury. [Front Neurosci] Abstract | Full Article

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Americord Advances Method of Obtaining Mesenchymal Stem Cells from the Placenta
Americord, announced that it has validated a revised process for the preservation of mesenchymal stem cells (MSCs) from placenta tissue. The new method greatly improves the success rate for preserving viable MSCs from Placenta Tissue, a service first developed in 2012. [PR Newswire Association LLC]
Press Release

New York Stem Cell Foundation Announces $10.5 Million to Seven New NYSCF-Robertson Investigators
The New York Stem Cell Foundation (NYSCF) named seven of the most promising scientists as its 2013 NYSCF – Robertson Investigators. Each Investigator will receive a $1.5 million award, which will be disbursed over the next five years, which will enable them to expand their laboratories and train other scientists. [The New York Stem Cell Foundation] Press Release

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NEW American Society of Hematology Annual Meeting 2013
December 7-10, 2013
New Orleans, United States

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NEW Postdoctoral Position – Human Pluripotent and Hematopoietic Stem Cell Bioinformatics (Albert Einstein College Medicine)

Translational Clinician-Scientist – Stem Cell Transplantation (Boston Children’s Hospital)

Postdoctoral Position – Patient-Specific Stem Cell Lines: Disease Modeling, Repair and Transplantation (Columbia University)

Postdoctoral Position – Cellular and Genetic Therapies for Hemoglobinopathies (Blood Systems Research Institute)

Postdoctoral Position – Immune Recovery after Hematopoietic Stem Cell Transplantation (University of Minnesota – Twin Cities)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Fellow – Differentiation of Erythrocytes and Endothelial Cells from Hemangioblast (University of Rochester)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

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