Volume 5.43 | Oct 31

Cord Blood News 5.43 October 31, 2013
Cord Blood News
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Vascular Progenitors from Cord Blood-Derived iPSC Possess Augmented Capacity for Regenerating Ischemic Retinal Vasculature
To evaluate the potential of human induced pluripotent stem cells (hiPSC) for treating ischemic retinopathies, researchers generated vascular progenitors from a repertoire of viral-integrated and non-integrated fibroblast and cord blood-derived hiPSC lines, and tested their capacity for homing and engrafting into murine retina in an ischemia-reperfusion model. [Circulation] Abstract
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PUBLICATIONS ( Ranked by impact factor of the journal)
Transplantation of Cryopreserved Human Umbilical Cord Blood Mononuclear Cells Does Not Induce Sustained Recovery after Experimental Stroke in Spontaneously Hypertensive Rats
Researchers investigated the neurorestorative potential of cryopreserved human umbilical cord blood mononuclear cells after permanent middle cerebral artery occlusion in spontaneously hypertensive rats. [J Cereb Blood Flow Metab] Abstract

Contralateral Extremities Benefit from Locally Administered Bone Marrow-Derived Mononuclear Cells and Cord Blood Serum in Diabetic Ischemic Wound Healing
Impaired wound healing could be a disaster especially in diabetes and amputation is the major risk. Investigators evaluated the benefit of bone marrow-derived mononuclear cells and cord blood serum on wound healing. [Stem Cell Rev Rep] Abstract

Human Umbilical Cord Blood-Derived CD34 Positive Endothelial Progenitor Cells Stimulate Osteoblastic Differentiation of Cultured Human Periosteal-Derived Osteoblasts
Investigators examined the effects of human umbilical cord blood-derived CD34 positive endothelial progenitor cells on osteoblastic differentiation of cultured human periosteal-derived osteoblasts. [Tissue Eng Part A] Abstract

Transplantation of Umbilical Cord-Derived Mesenchymal Stem Cells into the Striata of R6/2 Mice: Behavioral and Neuropathological Analysis
Mesenchymal stem cells, isolated from the umbilical cord of day 15 gestation pups, were transplanted intrastriatally into 5-week-old R6/2 mice at either a low-passage or high-passage. Mice were tested behaviorally for 6 weeks using the rotarod task, the Morris water maze, and the limb-clasping response. [Stem Cell Res Ther] Abstract | Full Article

Conditioned Medium as a Strategy for Human Stem Cells Chondrogenic Differentiation
The authors aimed to achieve chondrogenic differentiation of two different sources of stem cells using conditioned medium, without adding growth factors. They tested both human bone marrow-derived mesenchymal stem cells and human Wharton’s jelly-derived stem cells. [Tissue Eng Regen Med] Abstract

Cotransplantation of Human Umbilical Cord-Derived Mesenchymal Stem Cells and Umbilical Cord Blood-Derived CD34+ Cells in a Rabbit Model of Myocardial Infarction
Scientists investigated the effect of hypoxic preconditioning on the immunomodulatory properties of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and the effect of cotransplantation of hUC-MSCs and human umbilical cord blood-derived CD34+ cells in a rabbit model of myocardial infarction. [Mol Cell Biochem] Abstract

Neuronal Cell Differentiation of Mesenchymal Stem Cells Originating from Canine Amniotic Fluid
Researchers investigated whether canine amniotic-fluid-derived mesenchymal stem cells can differentiate into neural precursor cells in vitro when exposed to neural induction reagent. [Hum Cell] Full Article

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Stem Cell Therapy to Protect and Repair the Developing Brain: A Review of Mechanisms of Action of Cord Blood and Amnion Epithelial Derived Cells
The authors explored the novel characteristics of human amnion epithelial cells and undifferentiated umbilical cord blood (UCB) cells, as well as UCB-derived endothelial progenitor cells and mesenchymal stem cells, and how immunomodulation and anti-inflammatory properties are principal mechanisms of action that are common to these cells, and which in turn may ameliorate the cerebral hypoxia and inflammation that are final pathways in the pathogenesis of perinatal brain injury. [Front Neuroendocrinol] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.
Mesoblast Updates Market on Registration Plans for GvHD Cell Product in Japan
Mesoblast Limited updated the market on product registration plans in Japan for its proprietary culture-expanded Mesenchymal Stem Cells (MSCs) in the treatment of steroidrefractory graft-versus-host disease (GvHD). Under a collaborative agreement, JCR Pharmaceuticals Co. Ltd. has exclusive rights in Japan to manufacture, develop and market Mesoblast’s culture-expanded MSCs in connection with the use of hematopoietic stem cells derived from peripheral blood, cord blood or bone marrow in the treatment of hematological malignancies. [Mesoblast Limited] Press Release

The Leukemia & Lymphoma Society Announces Recipients of the New Idea Award Grant Program
The Leukemia & Lymphoma Society announced the researchers who will receive The New Idea Award – a grant program designed to identify novel research strategies with high potential for significant impact on the future of blood cancer treatments. [The Leukemia & Lymphoma Society] Press Release

STEMSOFT Announces Authorization to Submit Full Suite of AGNIS-Supported CIBMTR Forms
STEMSOFT™ Software Inc (“STEMSOFT”) is pleased to announce that the Center for International Blood & Marrow Transplant Research (CIBMTR®) has certified STEMSOFTconnect: REGISTRY to electronically submit all available forms using the CIBMTR AGNIS system. [STEMSOFT Software Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW European Group for Blood and Marrow Transplantation 2014
March 30-April 2, 2014
Milan, Italy

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NEW Postdoctoral Research Fellows – Isolation of Stem Cells from Placenta and Amniotic Fluid (Wake Forest Institute for Regenerative Medicine)

NEW Adult Stem Cell Transplant Physician (John Theurer Cancer Center)

PhD Studentship – Identifying Drugs to Improve the Utility of Bone Marrow and Cord Blood Transplantation (Cardiff University)

Postdoctoral Position – Human Pluripotent and Hematopoietic Stem Cell Bioinformatics (Albert Einstein College Medicine)

Translational Clinician-Scientist – Stem Cell Transplantation (Boston Children’s Hospital)

Postdoctoral Position – Patient-Specific Stem Cell Lines: Disease Modeling, Repair and Transplantation (Columbia University)

Postdoctoral Position – Cellular and Genetic Therapies for Hemoglobinopathies (Blood Systems Research Institute)

Postdoctoral Position – Immune Recovery after Hematopoietic Stem Cell Transplantation (University of Minnesota – Twin Cities)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

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