Volume 5.46 | Nov 21

Cord Blood News 5.46 November 21, 2013
Cord Blood News
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Ligand-Independent FLT3 Activation Does Not Cooperate with MLL-AF4 to Immortalize/Transform Cord Blood CD34+ Cells
Investigators explored whether FLT3.TKD mutation or increased expression of FLT3.WT cooperates with MLL-AF4 to immortalize/transform cord blood-CD34+ hematopoietic stem/progenitor cells. [Leukemia] Abstract
New Cord Banking Software Solution from STEMSOFT
PUBLICATIONS ( Ranked by impact factor of the journal)
A Set of MicroRNAs Mediate Direct Conversion of Human Umbilical Cord Lining-Derived Mesenchymal Stem Cells into Hepatocytes
Scientists aimed to clarify the instructive role of six overexpressed microRNAs (miRNAs) (miR-1246, miR-1290, miR-148a, miR-30a, miR-424 and miR-542-5p) during hepatic differentiation of human umbilical cord lining-derived mesenchymal stem cells (hMSCs) and to test whether overexpression of any of these miRNAs is sufficient to induce differentiation of the hMSCs into hepatocyte-like cells. [Cell Death Dis] Full Article

Alveolar Macrophages Are Critical for the Inhibition of Allergic Asthma by Mesenchymal Stromal Cells
Using a mouse model of allergic asthma, scientists showed that administration of mesenchymal stromal cells isolated from human bone marrow, umbilical cord, or adipose tissue provoked a pronounced increase in alveolar macrophages and inhibited hallmark features of asthma, including airway hyperresponsiveness, eosinophilic accumulation, and Th2 cytokine production. [J Immunol] Abstract

Nanofiber-Expanded Human Umbilical Cord Blood-Derived CD34+ Cell Therapy Accelerates Murine Cutaneous Wound Closure by Attenuating Pro-Inflammatory Factors and Secreting IL-10
Using an excision wound model in NOD/SCID mice, scientists showed that nanofiber-expanded human umbilical cord blood-derived-CD34+ cells home to the wound site and significantly accelerate the wound-healing process compared to vehicle-treated control. [Stem Cell Res] Abstract

Storage Time Affects Umbilical Cord Blood Viability
The impact of delayed cryopreservation for up to three days on the viability of both CD45+ and CD34+ cell populations in 28 cord blood (CB) donations with volumes of 58.40±15.4mL was investigated to establish whether precryopreservation storage time could be extended from the current time of 24 to 48 hours in line with other CB banks. [Transfusion] Abstract

How Important Is Differentiation in the Therapeutic Effect of Mesenchymal Stromal Cells in Liver Disease?
After hepatic differentiation of umbilical cord-derived mesenchymal stromal cells (MSCs) in vitro, scientists detected both MSC and hepatocyte-like cell expressions of adhesion molecules and chemokine receptor CXCR4 by flow cytometry; immunosuppressive potential and hepatocyte growth factor expression were determined by means of enzyme-linked immunosorbent assay. [Cytotherapy] Abstract

Gestational Diabetes Induces Alterations in the Function of Neonatal Endothelial Colony Forming Cells
Children born to mothers with gestational diabetes mellitus (GDM) experience increased risk of developing hypertension, type 2 diabetes mellitus, and obesity. Disrupted function of endothelial colony forming cells (ECFCs) may contribute to this enhanced risk. The goal of this study was to determine if cord blood ECFCs from GDM pregnancies exhibit altered functionality. [Pediatr Res] Abstract

Effects of Octylphenol on the Expression of Cell Cycle-Related Genes and the Growth of Mesenchymal Stem Cells Derived from Human Umbilical Cord Blood
Investigators isolated human mesenchymal stem cells (MSCs) from umbilical cord blood and demonstrate that cultured MSCs express the surface marker, CD34, but not CD105. [Int J Mol Med] Abstract

Technical Bulletin: Assays For Cord Blood
The Evolving Art of Hematopoietic Stem Cell Transplantation: Translational Research in Post-Transplant Immune Reconstitution and Immunosuppression
The authors review studies of post-transplant immune recovery and approaches to achieve more selective immunosuppressive strategies. [Immunol Res] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
Kiadis Pharma Provides Positive Update on its Phase II Clinical Program with Blood Cancer Treatment ATIR™
Kiadis Pharma B.V. announced the successful Phase II enrollment of approximately ten patients of whom the majority have already been transplanted and received ATIR™. [Kiadis Pharma B.V.] Press Release

Phiten® and Professional Baseball Players Team Up with Be The Match® to Make More Cures Possible for Blood Cancer Patients
Phiten and professional baseball players C.J. Wilson, Josh Hamilton and J.B. Shuck have teamed up with Be The Match, the nonprofit organization dedicated to helping patients with blood cancers receive life-saving bone marrow and umbilical cord blood transplants. [Phiten Technology] Press Release

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NEW 19th Congress of the European Hematology Association
June 12-15, 2014
Milan, Italy

Visit our events page to see a complete list of events in the cord blood community.
NEW PhD Studentship – iNKT Cells to Prevent Graft versus Host Disease (University of Birmingham)

Postdoctoral Associate – Graft-vs.-Host Disease and Graft-vs.-Leukemia in Mouse Models (Yale University School of Medicine)

Clinical Researcher – Hematopoietic Stem Cell Transplant Program (Northwestern University- Feinberg School of Medicine)

Postdoctoral Research Fellows – Isolation of Stem Cells from Placenta and Amniotic Fluid (Wake Forest Institute for Regenerative Medicine)

Adult Stem Cell Transplant Physician (John Theurer Cancer Center)

Postdoctoral Position – Human Pluripotent and Hematopoietic Stem Cell Bioinformatics (Albert Einstein College Medicine)

Translational Clinician-Scientist – Stem Cell Transplantation (Boston Children’s Hospital)

Postdoctoral Position – Patient-Specific Stem Cell Lines: Disease Modeling, Repair and Transplantation (Columbia University)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

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