Volume 5.48 | Dec 5

Cord Blood News 5.48 December 5, 2013
Cord Blood News
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Differential Regulation of the Apoptotic Machinery during Megakaryocyte Differentiation and Platelet Production by Inhibitor of Apoptosis Protein Livin
To evaluate the potential role of Livin in thrombopoiesis, investigators used the human BCR-ABL+ cell line, LAMA-84, and cord blood CD34+ cells to induce differentiation toward megakaryocytes. [Cell Death Dis]
Full Article
Technical Bulletin: Assays For Cord Blood
PUBLICATIONS (Ranked by impact factor of the journal)
Rapid Transfer of Endothelial Cell Sheet Using a Thermosensitive Hydrogel and Its Effect on Therapeutic Angiogenesis
Thermosensitive hydrogels incorporated with multiple cell-interactive factors were developed as a substrate to form a monolayer of human umbilical vein endothelial cells that can be detached and transferrable to target sites as a cell-sheet in response to temperature change. [Biomacromolecules] Abstract

α-Santalol Inhibits the Angiogenesis and Growth of Human Prostate Tumor Growth by Targeting Vascular Endothelial Growth Factor Receptor 2-Mediated AKT/mTOR/P70S6K Signaling Pathway
Investigators used α-santalol and analyzed its inhibitory effects on human umbilical vein endothelial cells and Prostate tumor cells (PC-3 or LNCaP) in vitro. [Mol Cancer] Full Article

Hepatocyte-Like Cells Derived from Human Amniotic Epithelial Cells Can Be Encapsulated without Loss of Viability or Function In Vitro
Scientists investigated the characteristics of hepatocyte-like cells (HLC) generated from human amniotic epithelial cells and examined the effects of encapsulation on HLC viability, gene expression and function. [Stem Cell Dev] Abstract

Real-Time Monitoring and Control of Soluble Signaling Factors Enables Enhanced Progenitor Cell Outputs from Human Cord Blood Stem Cell Cultures
Researchers describe the development of a microbead-based process control system for the monitoring and control of endogenously produced signaling factors. This monitoring system was incorporated into a fed-batch bioreactor to regulate the accumulation of TGF-β1 in an umbilical cord blood cell expansion system. [Biotechnol Bioeng] Abstract

Hyperglycemia Modifies Energy Metabolism and Reactive Oxygen Species Formation in Endothelial Cells In Vitro
Scientists aimed to describe changes in the mitochondrial metabolism of human umbilical vein endothelial cells treated with high glucose concentrations and to indicate the actual source of reactive oxygen species in these cells. [Arch Biochem Biophys] Abstract

Ghrelin Protects Human Umbilical Vein Endothelial Cells against High Glucose-Induced Apoptosis via mTOR/P70S6K Signaling Pathway
The authors investigated the intracellular mechanisms responsible for anti-apoptotic effect of ghrelin on human umbilical vein endothelial cells (HUVEC). Treatment of HUVEC with ghrelin inhibited high glucose-induced cell apoptosis. [Peptides] Abstract

Reticulocytes from Cryopreserved Erythroblasts Support Plasmodium vivax Infection In Vitro
Researchers report an improved method of hematopoietic stem cell culture for P. vivax infection, which requires less time and produces higher or equivalent percentage of reticulocytes than previously reported systems. Reticulocytes were cultured from cryopreserved erythroblasts that were frozen after 8 day-cultivation of purified CD34+ cells from human umbilical cord blood. [Parasitol Int] Abstract

Modeling Normal and Malignant Human Hematopoiesis In Vivo through Newborn NSG Xenotransplantation
NOD/SCID mice harboring complete null mutation of Il2rg (NSG mice) lack T cells, B cells, and NK cells, and support high levels of engraftment by human cord blood hematopoietic stem cells and acute myeloid leukemia stem cells. [Int J Hematol] Abstract

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Immunological Characteristics of Human Umbilical Cord Mesenchymal Stem Cells and the Therapeutic Effects of Their Transplantation on Hyperglycemia in Diabetic Rats
In addition to achieving high levels of human hematopoietic cell engraftment, use of newborn NOD/SCID mice harboring complete null mutation of Il2rg (NSG mice) as recipients has enabled the investigation into how human cord blood hematopoietic stem cells generate mature immune subsets in vivo. [Int J Mol Med] Abstract

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Cord Blood Registry® and U.S. Women’s Health Alliance Launch Quality Initiative to Accelerate Clinical Research Using Umbilical Cord Stem Cells to Treat Various Medical Conditions
Cord Blood Registry® and the U.S. Women’s Health Alliance announced their partnership on a nationwide patient education and quality initiative to ensure all expectant parents understand their options regarding umbilical cord stem cell collection and possibly improve medical outcomes for their families. [PR Newswire Association LLC] Press Release

bluebird bio Announces First Patient Transplanted in Phase I/II HGB-205 Study for the Treatment of Beta-Thalassemia and Sickle Cell Anemia
bluebird bio, Inc. announced that the first subject with beta-thalassemia major has been enrolled in its Phase I/II HGB-205 study in France and has undergone infusion with bluebird bio’s LentiGlobin drug product in an autologous hematopoietic stem cell transplantation. [bluebird bio, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW World Stem Cells & Regenerative Medicine Congress 2014
May 20-22, 2014
London, United Kingdom

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NEW Clinical MD – Clinical Development Program for Oncology and Autoimmune Diseases (Immunomedics, Inc.)

NEW Chief Medical Officer – Novel Therapeutics in Oncology and Autoimmune Disease (Immunomedics, Inc.)

Director – Clinical Immunogenetics Laboratory (Fred Hutchinson Cancer Research Center)

PhD Studentship – iNKT Cells to Prevent Graft versus Host Disease (University of Birmingham)

Postdoctoral Associate – Graft-vs.-Host Disease and Graft-vs.-Leukemia in Mouse Models (Yale University School of Medicine)

Clinical Researcher – Hematopoietic Stem Cell Transplant Program (Northwestern University- Feinberg School of Medicine)

Postdoctoral Research Fellows – Isolation of Stem Cells from Placenta and Amniotic Fluid (Wake Forest Institute for Regenerative Medicine)

Adult Stem Cell Transplant Physician (John Theurer Cancer Center)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

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