Volume 6.00 | Jan 9

Cord Blood News 6.00 January 9, 2013
Cord Blood News
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Reduced Lymphoid Lineage Priming Promotes Human Hematopoietic Stem Cell Expansion
Researchers modulated expression levels of Inhibitor of DNA binding (ID) proteins to ask whether lineage priming affects self-renewal of human hematopoietic stem cells (HSCs). They found that lentiviral overexpression of ID proteins in cord blood HSCs biases myeloerythroid commitment at the expense of lymphoid differentiation. Conversely, reducing ID2 expression levels increases lymphoid potential. [Cell Stem Cell]
Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Repeated Administrations of Human Umbilical Cord Blood Cells Improve Disease Outcomes in a Mouse Model of Sanfilippo Syndrome Type III B
Sanfilippo syndrome type III B is an inherited disorder characterized by a deficiency of α-N-acetylglucosaminidase enzyme leading to accumulation of heparan sulfate in lysosomes and severe neurological deficits. The authors have previously shown that a single administration of human umbilical cord mononuclear cells (hUCB MNC) into Nagluknockout mice decreased behavioral abnormalities and tissue pathology. In this study, the researchers tested whether repeated doses of hUCB MNCs would be more beneficial than a single dose of cells. [Cell Transplant] Abstract

Feasibility of Autologous Cord Blood Cells for Infants with Hypoxic-Ischemic Encephalopathy
The authors aimed to assess the feasibility and safety of providing autologous umbilical cord blood cells to neonates with hypoxic-ischemic encephalopathy. [J Pediatr] Abstract

Efficiency and Safety of O6-Methylguanine DNA Methyltransferase (MGMTP140K)-Mediated In Vivo Selection in a Humanized Mouse Model
Efficient O6-methylguanine DNA methyltransferase (MGMTP140K)-mediated myeloprotection and in vivo selection have been demonstrated in numerous animal models and most recently in a Phase I clinical study in glioblastoma patients. To improve the safety of the procedure, scientists evaluated a self-inactivating lentiviral MGMTP140K vector for transduction of human cord blood-derived CD34+ cells followed by transplantation of the cells into NOD/LtSz-scid/Il2rγ−/− mice. [Hum Gene Ther] Abstract

Differential Effects of Epigenetic Modifiers on the Expansion and Maintenance of Human Cord Blood Stem/Progenitor Cells
Researchers compared the effects of several histone deacetylase inhibitors, including valproic acid and trichostatin A, alone or in combination with 5-aza-2’-deoxycytidine on the expansion of hematopoietic stem cells. [Biol Blood Marrow Transplant] Abstract

Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplant for Patients with Hemoglobinopathies using a Reduced Intensity Conditioning Regimen and Third-Party Mesenchymal Stromal Cells
Allogeneic hematopoietic stem cell transplantation for patients with a hemoglobinopathy can be curative but is limited by donor availability. While positive results are frequently observed in those with a HLA matched sibling donor, the use of unrelated donors has been complicated by poor engraftment, excessive regimen-related toxicity and graft-versus-host disease. As a potential strategy to address these obstacles, a pilot study was designed that incorporated both a reduced intensity conditioning and mesenchymal stromal cells. [Biol Blood Marrow Transplant] Abstract

Humoral Activity of Cord Blood-Derived Stem/Progenitor Cells: Implications for Stem Cell-Based Adjuvant Therapy of Neurodegenerative Disorders
Investigators compared the expression of neurotrophins and their receptors in specific umbilical cord blood stem/progenitor cell populations, including lineage-negative, CD34+, and CD133+ cells, with that in unsorted, nucleated cells. [PLoS One] Full Article

Instruction of Circulating Endothelial Progenitors In Vitro towards Specialized Blood-Brain Barrier and Arterial Phenotypes
Researchers proposed a new source of specialized endothelial cells based on cord blood circulating endothelial progenitors (EPCs). As prototype examples, they evaluated the capacity of EPCs to acquire properties characteristic of cerebral microvascular endothelial cells (blood-brain barrier) or of arterial endothelial cells, in specific inducing culture conditions. [PLoS One] Full Article

Regeneration of Full-Thickness Skin Defects Using Umbilical Cord Blood Stem Cells Loaded into Modified Porous Scaffolds
Investigators demonstrated the ability of cord blood-derived unrestricted somatic stem cells and chitosan-modified poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffold to promote skin regeneration. [ASAIO J] Abstract

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Allogeneic Transplantation for Myelofibrosis: For Whom, When, and What Are the True Benefits?
Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potentially curative therapy for myelofibrosis. Despite improved outcomes, morbidity and mortality of HSCT remain high. Here the authors examine recent data on patient selection, timing, and outcomes of HSCT in myelofibrosis. [Curr Opin Hematol] Abstract

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ThermoGenesis Signs Direct Supply Agreement with Cord Blood Registry
ThermoGenesis Corp. announced the signing of a five-year agreement to supply Cord Blood Registry® with ThermoGenesis’ AutoXpress® System cord blood processing system and disposables. [ThermoGenesis Corp.] Press Release

Cord Blood America, Inc. Earns AABB Accreditation
Cord Blood America, Inc. announced it has achieved AABB accreditation for cell therapy activity associated with cord blood processing, storage and distribution. [Cord Blood America, Inc.] Press Release

Pluristem Receives Key Placental Cell Therapy Patent in Australia
Pluristem Therapeutics, Inc. announced it has been granted a new patent in Australia. Patent #2008300185, titled “Methods for Cell Expansion and Uses of Cells and Conditioned Media Produced thereby for Therapy,” covers the use of adherent placental cells for the treatment of ischemia, which is a restriction of blood supply to tissues, and for treatments of conditions requiring connective tissue repair or regeneration. [Pluristem Therapeutics, Inc.] Press Release

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NEW Genetic Engineering of Mammalian Stem Cells
March 10-22, 2014
Cambridge, United Kingdom

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NEW PhD Candidates – Stem Cells and Biomedical Engineering (Queensland University of Technology – Translational Research Institute)

Postdoctoral Position – Lineage Specific Cellular Differentiation Models Utilizing Umbilical Cord Derived Mesenchymal Stem Cells (Singapore Institute for Clinical Sciences)

Postdoctoral Position – Stem Cells and Bioengineering (Queensland University of Technology/Translational Research Institute)

Clinical MD – Clinical Development Program for Oncology and Autoimmune Diseases (Immunomedics, Inc.)

Chief Medical Officer – Novel Therapeutics in Oncology and Autoimmune Disease (Immunomedics, Inc.)

PhD Studentship – iNKT Cells to Prevent Graft versus Host Disease (University of Birmingham)

Postdoctoral Associate – Graft-vs.-Host Disease and Graft-vs.-Leukemia in Mouse Models (Yale University School of Medicine)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

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