Volume 6.06 | Feb 20

Cord Blood News 6.06 February 20, 2014
Cord Blood News
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Human CD34+ Progenitor Cells Freshly Isolated from Umbilical Cord Blood Attenuate Inflammatory Lung Injury following Lipopolysaccharide Challenge
Researchers investigated the therapeutic potential of freshly isolated human umbilical cord blood CD34+ progenitor cells in a mouse model of acute lung injury. [PLoS One] Full Article
New Cord Banking Software Solution from STEMSOFT
PUBLICATIONS (Ranked by impact factor of the journal)
Frequent Human Herpesvirus-6 Viremia but Low Incidence of Encephalitis in Double-Unit Cord Blood Recipients Transplanted without Anti-Thymocyte Globulin
Cord blood transplantation (CBT) is a known risk factor for human herpesvirus-6 (HHV-6) infection. Investigators analyzed the nature of HHV-6 infections in 125 double-unit CBT recipients (median age 42 years) transplanted for hematologic malignancies with calcineurin-inhibitor/ mycophenolate mofetil prophylaxis and no anti-thymocyte globulin. [Biol Blood Marrow Transplant] Abstract

Characterization of Neutrophil Subsets in Healthy Human Pregnancies
Researchers analyzed the phenotype of low-density granulocytes and compared it to the phenotype of normal density granulocytes in maternal peripheral blood, placental biopsies and cord blood. [PLoS One] Full Article

Impact of Sex Incompatibility on the Outcome of Single-Unit Cord Blood Transplantation for Adult Patients with Hematological Malignancies
Donor-recipient sex incompatibility has been associated with transplant outcomes in allogeneic hematopoietic SCT. However, its effect on the outcome of cord blood transplantation (CBT) is yet to be clarified. Researchers retrospectively analyzed 191 adult patients who received single-unit CBT after myeloablative conditioning for malignant disease in our institute. [Bone Marrow Transplant] Abstract

Implication of Different Effector Mechanisms by Cord Blood-Derived and Peripheral Blood-Derived Cytokine-Induced Killer Cells to Kill Precursor B Acute Lymphoblastic Leukemia Cell Lines
Cord blood (CB) and peripheral blood (PB)-cytokine-induced killer (CIK) cells were differentiated. CD56+ CB- and PB-CIK cells were compared for expression of different phenotypic markers and for the lytic pathways used to kill B-cell acute lymphoblastic leukemia cell lines. [Cytotherapy] Abstract

Effective Expansion of Engrafted Human Hematopoietic Stem Cells in Bone Marrow of Mice Expressing Human Jagged-1
To prepare the relatively human bone marrow environment in mice, the authors generated non-obese diabetic/severe combined immunodeficiency/IL-2 receptor gamma chain null (NOG) mice expressing human Jagged1 (hJ1) in an osteoblast-specific manner (hJ1-NOG mice) to examine whether Notch signaling induced by hJ1 mediates hHSC proliferation and/or maintenance in mice. In the transplantation experiments of CD34+ cells obtained from human cord blood, CD34+CD38 cells were more increased in hJ1-NOG recipient mice than in non-transgenic littermates in mouse bone marrow environment. [Exp Hematol] Abstract

IL-27 Improves Migrational and Antiviral Potential of CB Dendritic Cells
Scientists examined effects of interleukin (IL)-27 on monocyte derived dendritic cells (moDCs) to approach its particular role in the specialized immune system of the human neonate. Exogenous IL-27 promotes IL-27 transcription in cord blood (CB) and adult blood moDCs. [Hum Immunol] Abstract

Epstein-Barr Virus Induces the Differentiation of Semi-Mature Dendritic Cells from Cord Blood Monocytes
Researchers compared the effects of Epstein-Barr virus on cord blood (CB) and adult dendritic cells (DCs) differentiation and maturation including phenotype by flow cytometry, cytokine by ELISA and RT-PCR. They evaluated the function of DC by co-culture DC and regulatory T cells (Tregs) by detection the expression of Foxp3, the phenotype and the cytokine profile of Tregs by flow cytometry. [Hum Immunol] Abstract

Comparison of Human Mesenchymal Stem Cells Isolated by Explant Culture Method from Entire Umbilical Cord and Wharton’s Jelly Matrix
Investigators compared two simple and cost-effective explant culture methods for isolation of mesenchymal stem cells from human umbilical cord. [Cell Tissue Bank] Abstract

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FREE Technical Resource: Atlas of Hematopoietic Colonies from Cord Blood. Request your copy.
Ex Vivo Production of Platelets from Stem Cells
There has been initial success in ex vivo generation of platelets from stem cells using cord blood stem cells, embryonic stem cells and induced pluripotent stem cells. However, the platelet yields achieved by these strategies have not been sufficient for clinical purposes. This review provides updated information about the current strategies of ex vivo generation of platelets. [Br J Haematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Attend ISCT 2014 in Paris, France!
Cesca Therapeutics Inc., Formerly ThermoGenesis Corp., Closes Merger with TotipotentRX Corporation and Changes Name
Cesca Therapeutics Inc. announced that it consummated the merger with TotipotentRX Corporation for approximately 12,490,800 shares of the company’s common stock, as contemplated by the previously announced Agreement and Plan of Reorganization. [Cesca Therapeutics Inc.] Press Release

STC Life Co., Ltd. Successfully Treats Patients with Parkinson’s Disease at Stem Cell Research and Treatment Center
Stem cell research institute of STC Life Co., Ltd. and 97.7 B&H Clinic successfully completed mesenchymal stem cell therapy for the patients with Parkinson’s disease. Mesenchymal stem cells, one of the adult stem cells, are used a lot for neogenesis, and the stem cell research institute of STC Life Co., Ltd. used stem cells separated from the umbilical cord of fetus. [Business Wire] Press Release

From our sponsor: Free mouse hematopoietic progenitors wallchart. Request your copy.
AAAS Launches Open-Access Journal
Joining a herd of other scientific societies, AAAS (American Association for the Advancement of Science) announced that it will launch the organization’s first online, fully open-access journal early next year. The new journal, called Science Advances, will give authors another outlet for papers that they are willing to pay to make immediately free to the public. [ScienceInsider] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW American Society of Gene & Cell Therapy (ASGCT) 17th Annual Meeting
May 21-24, 2014
Washington, DC, United States

NEW International Society for Stem Cell Research (ISSCR) 12th Annual Meeting
June 18-21, 2014
Vancouver, Canada

Visit our events page to see a complete list of events in the cord blood community.
NEW Assistant/Associate Professor – Hematology (Erasmus MC)

NEW Postdoctoral Position – Hematopoietic Stem Cell Self-Renewal (University of Iowa)

Postdoctoral Associate – Hematopoietic Malignancies (University of Miami)

Director – Clinical Immunogenetics Laboratory (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Stem Cells (Imagine Institute)

Postdoctoral Position – Hematopoietic Stem Cell Biology (St. Jude Children’s Research Hospital)

Postdoctoral Positions – Hematopoietic Stem Cell Physiology and Bone Marrow Failure (University of Michigan)

Assistant Professorship – Hematopoietic Stem Cells and Microenvironment (University of Zurich)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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