Volume 6.10 | Mar 20

Cord Blood News 6.10 March 20, 2014
Cord Blood News
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Study Finds Stem Cell Combination Therapy Improves Traumatic Brain Injury Outcomes
In their study of several different therapies – alone and in combination – applied to laboratory rats modeled with traumatic brain injuries, researchers found that a combination of human umbilical cord blood cells and granulocyte colony stimulating factor was more therapeutic than either administered alone, or each with saline, or saline alone. [Press release from the University of South Florida discussing online prepublication in PLoS One] Press Release | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Reactive Oxygen Species Induce Matrix Metalloproteinase-12-Dependent Degradation of Collagen 5 and Fibronectin to Promote the Motility of Human Umbilical Cord Derived Mesenchymal Stem Cells
The authors investigated the role of hydrogen peroxide in promoting umbilical cord blood derived mesenchymal stem cell motility and its related signaling pathways. [Br J Pharmacol] Abstract

Cryopreservation Effects on Wharton’s Jelly Stem Cells Proteome
Researchers investigated molecular changes that occur in Wharton’s Jelly stem cells proteome in different experimental conditions: fresh primary cell culture and frozen cell. [Stem Cell Rev] Abstract

Incidence and Outcome of Invasive Fungal Diseases after Allogeneic Stem Cell Transplantation: A Prospective Study of the Gruppo Italiano Trapianto Midollo Osseo (GITMO)
Epidemiological investigation on invasive fungal diseases (IFD) in allogeneic hematopoietic stem cell transplant may be useful to identify sub-populations who might benefit from targeted strategies. Using logistic regression methods researchers did analyses in order to identify risk factors for proven/probable IFD (PP-IFD) during the early (days 0-40), late (days 41-100) and very late (days 101-365) phases after transplant and to evaluate the impact of PP-IFDs on the one-year overall-survival. [Biol Blood Marrow Transplant] Abstract

Effects of THAP11 on Erythroid Differentiation and Megakaryocytic Differentiation of K562 Cells
Researchers showed that THAP11 was down-regulated during erythroid differentiation but up-regulated during megakaryocytic differentiation of cord blood CD34+ cells. [PLoS One] Full Article

Cell-Based Regenerative Strategies for Treatment of Diabetic Skin Wounds, a Comparative Study between Human Umbilical Cord Blood-Mononuclear Cells and Calves’ Blood Hemodialysate
Systemic administration of human umbilical cord blood (HUCB) derived mononuclear cells and topical application of the newly prepared HUCB-hemodialysate (HD) or calves’ blood HD significantly accelerated the rate of diabetic wound healing and would open the possibility of their future use in regenerative medicine. [PLoS One] Full Article

Functional Differentiation of Midbrain Neurons from Human Cord Blood-Derived Induced Pluripotent Stem Cells
Researchers aimed to establish a differentiation strategy to efficiently generate neurons including dopaminergic cells from human cord blood-derived induced pluripotent stem cells as a juvenescent cell source and prove their functional maturation in vitro. [Stem Cell Res Ther] Abstract | Full Article

Aldehyde Dehydrogenase-Bright Cells Correlated with the Colony-Forming Unit-Granulocyte-Macrophage Assay of Thawed Cord Blood Units
The number of aldehyde dehydrogenase-bright (ALDHbr) cells has been suggested as a viable marker of hematopoietic stem cell function. Researchers evaluated the suitability of ALDHbr cell analysis in the quality assessment of post-thaw cord blood units. [Transfusion] Abstract

Effect of Human Umbilical Cord Blood Mesenchymal Stem Cell Transplantation on Neuronal Metabolites in Ischemic Rabbits
Because there is little research on the effects of transplanted stem cells on neuronal metabolites in infarct areas, researchers transplanted human umbilical cord blood mesenchymal stem cells into cerebral ischemic rabbits and examined the neuronal metabolites. [BMC Neurosci] Abstract | Full Article

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Hematopoietic Stem Cell Transplantation in Children with Autoimmune Connective Tissue Diseases
The authors provide an overview of the knowledge concerning actual data on hematopoietic stem cell transplantation in a pediatric group of patients with different autoimmune connective tissue diseases, focused on juvenile idiopathic arthritis, systemic lupus erythematosus and systemic sclerosis. [Arch Immunol Ther Exp] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
AIM Receives $1 Million Gift to Advance Stem Cell Research
Inaugurating a new era of philanthropic giving for stem cell research in Alabama, the Alabama Institute of Medicine (AIM) announced the generous donation of $1 Million dollars from an anonymous Birmingham resident. [Alabama Institute of Medicine] Press Release

Statewide Public Cord Blood Collection Program Begins
Mothers of newborns can now donate their babies’ umbilical cord blood at UC Davis Medical Center and other hospitals throughout the state as part of California’s first comprehensive public system of collecting cord blood for lifesaving transplantations and medical research. [UC Davis Health System] Press Release

Fate Therapeutics Appoints Dr. Robert S. Epstein to Its Board of Directors
Fate Therapeutics, Inc., a biopharmaceutical company engaged in the discovery and development of adult stem cell modulators to treat orphan diseases, announced that Dr. Robert S. Epstein, M.D., has joined its Board of Directors. [Fate Therapeutics, Inc.] Press Release

Cerebral Palsy and the Potential of Cord Blood Stem Cells
Cord Blood Registry® is partnering with two preeminent institutions, the University of Texas Health Science Center at Houston and Georgia Regents University, to establish FDA-regulated clinical trials investigating whether an intravenous infusion of a child’s own cord blood cells, banked at the time of their birth, will lessen the symptoms of cerebral palsy. [PR Newswire Association LLC] Press Release

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Alliance for Regenerative Medicine Announces Introduction of Regenerative Medicine Promotion Act of 2014 in the Senate
The Alliance for Regenerative Medicine announced the introduction of the Regenerative Medicine Promotion Act of 2014 in the U.S. Senate and expressed appreciation for the efforts of its lead sponsors, Senators Barbara Boxer (D-CA) and Mark Kirk (R-IL). [Alliance for Regenerative Medicine] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 5th International Congress on Stem Cells and Tissue Formation
July 8-11, 2014
Dresden, Germany

Visit our events page to see a complete list of events in the cord blood community.
NEW Postdoctoral Position – Hematopoietic Stem Cell & Neutrophil Cell Polarity (Cincinnati Children’s Hospital Medical Center)

Cell Therapy Lab Technologist II (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – Human Stem Cell Biology and Hematopoiesis (Johns Hopkins University School of Medicine)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Director – Clinical Immunogenetics Laboratory (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – Hematopoietic Stem Cell Biology (St. Jude Children’s Research Hospital)

Postdoctoral Positions – Hematopoietic Stem Cell Physiology and Bone Marrow Failure (University of Michigan)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

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