Volume 6.13 | Apr 10

Cord Blood News 6.13 April 10, 2014
Cord Blood News
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A Novel Procedure to Improve Functional Preservation of Hematopoietic Stem and Progenitor Cells in Cord Blood Stored at +4°C before Cryopreservation
In order to improve cord blood (CB) units storage efficiency, the authors conceived an approach based on two principles: to provide a better nutritive and biochemical environment to stem and progenitor cells in CB and to prevent the hyperoxygenation of these cells transferred from a low- to a high-oxygen concentration. [Stem Cells Dev] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Existence, Functional Impairment and Lung Repair Potential of Endothelial Colony Forming Cells in Oxygen-Induced Arrested Alveolar Growth
Intra-jugular administration of human cord blood-derived endothelial colony forming cells after established arrested alveolar growth restored lung function, alveolar and lung vascular growth and attenuated pulmonary hypertension. [Circulation] Abstract

Late Onset Colitis after Cord Blood Transplant Is Consistent with Graft-versus-Host Disease: Results of a Blinded Histopathological Review
Scientists tested the hypothesis that recipients of umbilical cord blood transplantation had late-occurring colitis distinct from graft-versus-host disease and colitis in other allograft recipients. [Biol Blood Marrow Transplant] Abstract

FOXP3 Is a Direct Target of miR15a/16 in Umbilical Cord Blood Regulatory T Cells
Exact mechanism of action of umbilical cord blood (CB)-derived regulatory T cells (Tregs) in the prevention of GvHD remains unclear. On the basis of selective overexpression of peptidase inhibitor 16 in CB Tregs, researchers explored the related p53 pathway, which has been shown to negatively regulate miR15a/16 expression. [Bone Marrow Transplant] Abstract

No Evidence of Clonal Dominance after Transplant of HOXB4-Expanded Cord Blood Cells in a Nonhuman Primate Model
Researchers previously reported the development of leukemia in several nonhuman primate subjects transplanted with HOXB4-expanded bone marrow cells at approximately two years post-transplant. Here, they provide long-term data for a nonhuman primate receiving a HOXB4-expanded cord blood graft. [Exp Hematol] Abstract

Mir-302 Cluster Exhibits Tumor Suppressor Properties on Human Unrestricted Somatic Stem Cells
Previous reports have shown the participation of miR-302-367 cluster in cell cycle regulation of human embryonic stem cells, MCF7, HepG2, and Teta-2 embryonal teratocarcinoma cells, but its effect on unrestricted somatic stem cells as a new source of human somatic stem cells from the umbilical cord blood remains to be elucidated. Researchers investigated the effect of miR-302-367 cluster on cell proliferation by MTT assay, cell cycle analysis, and colony formation assay. [Tumor Biol] Abstract

Mir-218 Contributes to the Transformation of 5-Aza/GF Induced Umbilical Cord Mesenchymal Stem Cells into Hematopoietic Cells through the MITF Pathway
Researchers demonstrated that umbilical cord-derived human mesenchymal stem cells are easily accessible and could be induced into cells with hematopoietic function. Furthermore, they focused on the crucial miRNAs and relative transcription factors. [Mol Biol Rep] Abstract

A Simple and Serum-Free Protocol for Cryopreservation of Human Umbilical Cord as Source of Wharton’s Jelly Mesenchymal Stem Cells
Investigators optimized a serum-free formulation of 10% dimethyl sulfoxide and 0.2M sucrose for cryopreservation of umbilical cord tissue. [Cryobiology] Abstract

Effects of Bone Marrow Mesenchymal Stem Cells on Hematopoietic Recovery and Acute Graft-versus-Host Disease in Murine Allogeneic Umbilical Cord Blood Transplantation Model
Researchers investigated the effect of bone marrow mesenchymal stem cells on hematopoietic recovery and acute graft-versus-host disease in a murine allogeneic umbilical cord blood transplantation model. [Cell Biochem Biophys] Abstract

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Advances in Umbilical Cord Blood Transplant: A Summary of the 11th International Cord Blood Symposium, San Francisco, 6-8 June 2013
Results of cord blood transplant (UCB SCT) for congenital storage disease and hemoglobinopathies are encouraging, but UCB SCT may also be useful for older adults with hematologic malignancies, and UCB cells have potential in regenerative medicine, particularly for neurological disorders, and may serve as excellent targets for gene therapy. [Leuk Lymphoma] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

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Americord Launches Corporate Giving Program
Americord announced the launch of its corporate giving program, which will support research focused on the therapeutic uses of stem cells from umbilical cord blood, cord tissue and placenta tissue. In addition to ongoing and future clinical trials focused on a broad array of diseases, conditions, and injuries, Americord’s corporate giving program may also fund research related to stem cell technologies with broad applications in the field. [Americord Registry LLC] Press Release

Mahendra Rao Joins The New York Stem Cell Foundation Research Institute
Dr. Mahendra Rao, who has directed the Center for Regenerative Medicine at the National Institutes of Health since 2010, will join The New York Stem Cell Foundation Research Institute as its Vice President for Regenerative Medicine, a newly created position. [The New York Stem Cell Foundation] Press Release

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NIH Stem-Cell Program Closes
Stem-cell researchers at the US National Institutes of Health (NIH) have been left frustrated and confused following the demise of the agency’s Center for Regenerative Medicine. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Future Investigators of Regenerative Medicine (FIRM) Symposium 2014
September 8-11, 2014
Girona, Spain

Visit our events page to see a complete list of events in the cord blood community.
NEW Postdoctoral Position – Hematopoiesis (Albany Medical Center)

Postdoctoral Fellow – Stem Cell Research (Washington University School of Medicine)

Postdoctoral Research Associate – Hematopoietic Stem Cell Gene Therapy (Washington State University)

Postdoctoral Fellow – Hematopoietic Stem Cell and Leukemia Research (City of Hope)

Postdoctoral Position – Hematopoietic Stem Cell & Neutrophil Cell Polarity (Cincinnati Children’s Hospital Medical Center)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – Human Stem Cell Biology and Hematopoiesis (Johns Hopkins University School of Medicine)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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