Volume 6.15 | Apr 24

Cord Blood News 6.15 April 24, 2014
Cord Blood News
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A Red-Shifted Fluorescent Substrate for Aldehyde Dehydrogenase
Researchers report a red-shifted fluorescent substrate for aldehyde dehydrogenase (ALDH), AldeRed 588-A, for labeling viable ALDHpos cells. They demonstrated that AldeRed 588-A successfully isolates ALDHhi human hematopoietic stem cells from heterogeneous cord blood mononuclear cells. [Nat Commun] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
A CD8 T Cell-IDO Axis Is Required for Mesenchymal Stem Cell Suppression of Human SLE
Researchers investigated how allogeneic mesenchymal stem cells (MSCs) mediate immune-suppression in lupus patients. The effects on inhibiting T cell proliferation by allogeneic umbilical cord derived MSCs were determined. [Arthritis Rheumatol] Abstract

Decreased Level of Cord Blood Circulating Endothelial Colony-Forming Cells in Preeclampsia
Investigators sought to determine whether cord blood endothelial colony-forming cell abundance and function are altered in preeclampsia. [Hypertension] Abstract

Sphingosine Kinase 1 Expressed by Endothelial Colony-Forming Cells Has a Critical Role in Their Revascularization Activity
Conditioned medium from human bone marrow-derived mesenchymal stem cells increased the angiogenic activity of cord blood endothelial colony-forming cells (ECFCs) in vitro (proliferation, migration, and pseudo-tube formation), the survival of ECFCs in mice (Matrigel Plug assay) and the capacity of ECFCs to promote the recovery of blood perfusion in mice with hindlimb ischemia. [Cardiovasc Res] Abstract

Netrin-1 Induces MMP-12-Dependent E-Cadherin Degradation via the Distinct Activation of PKCα and FAK/Fyn in Promoting Mesenchymal Stem Cells Motility
Scientists investigated the role of netrin-1 in promoting the motility of human umbilical cord blood derived mesenchymal stem cells and its related signaling pathways. [Stem Cells Dev] Abstract

Relationship of BK Polyoma Virus (BKV) in the Urine with Hemorrhagic Cystitis and Renal Function in Recipients of T-Cell Depleted Peripheral Blood and Cord Blood Stem Cell Transplants
Researchers prospectively monitored 98 hematopoietic stem cell transplants by serial BKV PCR in the urine through Day (D) +100 to analyze the relationship between BKV viruria and hemorrhagic cystitis, serum creatinine and creatinine clearance through D +180 or death. Patients, median age 52 years, range 20-73, received T-cell depleted or cord blood allografts. [Biol Blood Marrow Transplant] Abstract

Increased Migration of Human Mesenchymal Stromal Cells by Autocrine Motility Factor (AMF) Resulted in Enhanced Recruitment towards Hepatocellular Carcinoma
Researchers analyzed AMF involvement on mesenchymal stromal cell (MSC) migration towards human hepatocellular carcinoma. The effects of AMF on MSCs from different sources (bone marrow, adipose tissue and perivascular cells from umbilical cord) were analyzed using in vitro migration assay; metalloproteinase 2 activity and expression of critical genes were studied by zymography and qRT-PCR, respectively. [PLoS One]
Full Article

Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Induce Apoptosis in PC-3 Prostate Cancer Cells through Activation of JNK and Downregulation of PI3K/AKT Signaling
Investigators elucidated the antitumor activity of human umbilical cord mesenchymal stem cells (hUCMSCs) in PC-3 prostate cancer cells in vitro and in vivo. Antitumor effects of UCMSCs on tumor growth were evaluated in a co-culture condition with PC-3 prostate cancer cells. PC-3 cells were subcutaneously (sc) injected into the left flank of nude mice and UCMSCs were sc injected into the right flank of the same mouse. [Stem Cell Res Ther] Abstract | Full Article

Extracellular O-Linked N-Acetylglucosamine Is Enriched in Stem Cells Derived from Human Umbilical Cord Blood
Researchers were able to show by immunological assays that human umbilical cord blood-derived mesenchymal stromal cells display O-linked N-acetylglucosamine (O-GlcNAc), the product of epidermal growth factor domain-specific O-linked GlcNAc transferase, and that O-GlcNAc is further elongated with galactose to form O-linked N-acetyllactosamine. [Biores Open Access] Full Article | Press Release

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Tissue Engineering Red Blood Cells: A Therapeutic
The authors provide a review about developing alternatives for blood transfusion, with the emphasis on tissue-engineering approaches. [J Tissue Eng Regen Med] Abstract

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Fate Therapeutics Announces FDA Clearance of IND Amendment for Clinical Development of PROHEMA® in Pediatric Patients
Fate Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug Application (IND) amendment to evaluate PROHEMA® in pediatric patients undergoing hematopoietic stem cell transplantation for the treatment of hematologic malignancies. [Fate Therapeutics, Inc.] Press Release

Cryo-Cell’s New Cord Blood Processing Method Enables Parents to Obtain Better Cord Blood Units for Their Babies
New PrepaCyte® CB cord blood processing technology improves viable stem cell recovery and removes 99% of red blood cell contaminants. [Cryo-Cell International, Inc.] Press Release

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NEW Scientific Researcher/PhD Candidate – Epigenetics (Erasmus MC)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (The Research Institute, Nationwide Children’s Hospital)

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Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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