Volume 6.17 | May 8

Cord Blood News 6.17 May 8, 2014
Cord Blood News
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Peripheral Blood Cells Chimerism after Unrelated Cord Blood Transplantation in Children: Kinetics, Predictive Factors and Impact on Post-Transplant Outcome
Investigators aimed to describe kinetics of complete donor chimerism occurrence after unrelated cord blood transplantation, to identify its predictive factors and its impact on post-transplant outcome. [Br J Haematol] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Engineering the Human Thymic Microenvironment to Support Thymopoiesis In Vivo
Researchers developed an implantable thymic microenvironment composed of two human thymic stroma populations critical for thymopoiesis; thymic epithelial cells and thymic mesenchyme. Cord blood hematopoietic stem and progenitor cells previously engrafted into murine bone marrow, migrated to implants and differentiated into human T cells with a broad T cell receptor repertoire. [Stem Cells] Abstract

Alterations in Regulatory T Cell Subpopulations Seen in Preterm Infants
Scientists aimed to measure the percentages of two different regulatory T cells subpopulations, identified by the presence or absence of CD31 (Recent thymic emigrants and peripherally induced naïve regulatory T cells), in term and preterm infant cord blood. [PLoS One] Full Article

Reduced Toxicity, Myeloablative Conditioning with BU, Fludarabine, Alemtuzumab and SCT from Sibling Donors in Children with Sickle Cell Disease
The authors investigated in a prospective single institutional study, the safety and efficacy of a reduced-toxicity conditioning regimen of BU 12.8-16 mg/kg, fludarabine 180 mg/m2, alemtuzumab 54 mg/m2 before HLA-matched sibling donor transplantation in pediatric recipients with symptomatic sickle cell disease. Eighteen patients, median age 8.9 years, M/F 15/3, 15 sibling BM and three sibling cord blood were transplanted. [Bone Marrow Transplant] Abstract

Comparative Analysis of Multilineage Properties of Mesenchymal Stromal Cells Derived from Fetal Sources Shows an Advantage of Mesenchymal Stromal Cells Isolated from Cord Blood in Chondrogenic Differentiation Potential
Researchers showed that cord blood-mesenchymal stromal cells (MSCs) and amniotic fluid-MSCs collected at term differ from each other in their biological and differentiation properties. [Cytotherapy] Abstract

γ-Irradiated Cord Blood MNCs: Different Paracrine Effects on Mature and Progenitor Endothelial Cells
Investigators tested in vitro pro-angiogenic effects of apoptotic cord blood-derived mononuclear cells (MNCs) and their conditioned medium on mature endothelial cells and peripheral blood-derived endothelial progenitor cells. [Microvasc Res] Abstract

Medium Conditioned with MSC-Derived Osteoblasts Improves the Expansion and Engraftment Properties of Cord Blood Progenitors
Researchers assessed the growth and engraftment modulatory activities of mesenchymal stromal cell (MSC)-derived osteoblasts (M-OST) on hematopoietic progenitors. The expansion of cord blood CD34+ cells and myeloid progenitors was highest in cultures supplemented with unfiltered M-OST conditioned medium. [Exp Hematol] Abstract

Cord Blood CD34+ Cells Expanded on Wharton’s Jelly Multipotent Mesenchymal Stromal Cells Improve the Hematopoietic Engraftment in NOD/SCID Mice
Scientists investigated the capability of Wharton’s jelly multipotent mesenchymal stromal cells to support the in vitro expansion of hematopoietic stem/progenitor cells derived from cord blood in the absence of exogenous cytokines, and the effect on engraftment of the expanded cells in a mouse model. [Eur J Haematol] Abstract

Combined Umbilical Cord Blood and Bone Marrow from HLA-Identical Sibling Donors for Hematopoietic Stem Cell Transplantation in Children with Hemoglobinopathies
Investigators analyzed the feasibility and outcome of hematopoietic stem cell transplantation in 13 children with hemoglobinopathies after the co- infusion of cord blood and bone marrow from the same human leucocyte antigen (HLA) identical sibling donor. [Pediatr Blood Cancer] Abstract

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Stem Cells and Calcium Phosphate Cement Scaffolds for Bone Regeneration
The authors review recent developments in stem cell delivery via calcium phosphate cement (CPC) for bone regeneration. This includes: biofunctionalization of the CPC scaffold, co-culturing of osteoblasts/endothelial cells and prevascularization of CPC, seeding of CPC with different stem cell species, human umbilical cord mesenchymal stem cell (MSC) and bone marrow MSC seeding on CPC for bone regeneration, and human embryonic stem cell and induced pluripotent stem cell seeding with CPC for bone regeneration. [J Dent Res] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Stem Cells and Regenerative Medicine Asia Congress 2014
Americord Funds Clinical Trial Investigating Stem Cell Therapy for Alzheimer’s Disease
Americord announced that it has provided funding to MEDIPOST to support their clinical trial investigating the use of NEUROSTEM-AD® in the treatment of patients with Alzheimer’s Disease. NEUROSTEM-AD® is a treatment agent for Alzheimer’s Disease that uses human umbilical cord blood-derived mesenchymal stem cells. [Americord Registry] Press Release

UGA to Use $5 Million Gift to Support Center for Molecular Medicine
A $5 million gift to support the Center for Molecular Medicine at the University of Georgia (UGA) will allow the institution to greatly advance its research into human disease. [University of Georgia] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Florida Association of Blood Banks Pre-Meeting Symposium
June 4, 2014
Sarasota, United States

Visit our events page to see a complete list of events in the cord blood community.
NEW Postdoctoral Researcher – HLA and Non-HLA Genetic Markers in Hematopoietic Stem Cell Transplantation (NHS Blood and Transplant)

Research Associate – Hematopoietic Stem Cell Development (King’s College London)

Scientific Researcher/PhD Candidate – Epigenetics (Erasmus MC)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (The Research Institute, Nationwide Children’s Hospital)

Assistant/Associate Professor – Blood Bank and Transfusion Medicine (University of Virginia Health System)

Postdoctoral Position – Hematopoiesis (Albany Medical Center)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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