Volume 6.18 | May 15

Cord Blood News 6.18 May 15, 2014
Cord Blood News
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Human Wharton’s Jelly Stem Cells, Its Conditioned Medium and Cell-Free Lysate Inhibit the Growth of Human Lymphoma Cells
The authors evaluated the influence of mesenchymal stem cells from the gelatinous matrix of the Wharton’s jelly of the human umbilical cord (hWJSCs) and its extracts on Burkitt’s lymphoma cells. Cell proliferation, viability and cell death assays showed significant inhibition of lymphoma cell growth after 48 hours exposure to hWJSCs or its extracts compared to controls. [Stem Cell Rev] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
MicroRNA-34a Targets Forkhead Box j2 to Modulate Differentiation of Endothelial Progenitor Cells in Response to Shear Stress
Scientists sought to determine the effects of microRNA-34a and a novel target Forkhead box j2 on shear stress-induced endothelial progenitor cell (EPC) differentiation. Human umbilical cord blood-derived EPCs were exposed to laminar shear stress of 15 dyn/cm2 with parallel plate flow chamber system. [J Mol Cell Cardiol] Abstract

Endothelial Progenitor Cells Derived from Wharton’s Jelly of Human Umbilical Cord Attenuate Ischemic Acute Kidney Injury by Increasing Vascularization and Decreasing Apoptosis, Inflammation, and Fibrosis
Researchers examined the therapeutic potential of implantation of endothelial progenitor cells isolated from Wharton’s jelly of human umbilical cord in the treatment of renal ischemia/reperfusion injury in mice. [Cell Transplant] Full Article

Microvesicles Derived from Human Wharton’s Jelly Mesenchymal Stem Cells Promote Human Renal Cancer Cell Growth and Aggressiveness through Induction of Hepatocyte Growth Factor
In a previous study, microvesicles (MVs) released from human Wharton’s jelly mesenchymal stem cells retard the growth of bladder cancer cells. Researchers would like to know if MVs have a similar effect on human renal cell carcinoma (RCC). By use of cell culture and the BALB/c nu/nu mice xeno-graft model, the influence of MVs upon the growth and aggressiveness of RCC (786-0) was assessed. [PLoS One] Full Article

Human Amniotic Fluid Stem Cells: Neural Differentiation In Vitro and In Vivo
Scientists tested the neural differentiation potential of c-Kit+/Oct-4+ human amniotic fluid stem cells in vitro and their survival and integration in vivo. [Cell Tissue Res] Abstract

Changes in PTTG1 by Human TERT Gene Expression Modulate the Self-Renewal of Placenta-Derived Mesenchymal Stem Cells
Researchers aimed to generate immortalized MSCs derived from MSCs isolated from placenta (naive) by human TERT gene transfection with the AMAXA gene delivery system, to compare their characteristics, and to investigate whether increased TERT expression affected the pituitary tumor transforming gene (PTTG1; also known as securin), which is involved in chromosome segregation during mitosis. [Cell Tissue Res] Abstract

Human Cord Blood Stem Cell Paracrine Factors Activate the Survival Protein Kinase Akt and Inhibit Death Protein Kinases JNK and p38 in Injured Cardiomyocytes
Investigators hypothesized that paracrine factors from human umbilical cord blood mononuclear cells activate in injured cardiomyocytes the survival protein kinase Akt and limit activation of death protein kinases JNK and p38. [Cytotherapy] Abstract

Nicotine Promotes Late Endothelial Progenitor Cells Functional Activity in a Phosphatidylinositol 3-Kinase-Dependent Manner
Researchers investigated whether nicotine had influences on the functional activity of late endothelial progenitor cells (EPCs). Late EPCs were isolated from human umbilical cord blood and characterized. [Cell Biochem Biophys] Abstract

Amniotic Fluid-Derived Mesenchymal Stem Cells Prevent Fibrosis and Preserve Renal Function in a Preclinical Porcine Model of Kidney Transplantation
To determine the efficiency and the safety of amniotic fluid-derived mesenchymal stem cells (af-MSCs) infusion in a preclinical porcine model of renal autotransplantation, researchers injected autologous af-MSCs in the renal artery six days after transplantation. [Stem Cells Transl Med] Abstract

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Interaction of Wharton’s Jelly Derived Fetal Mesenchymal Cells with Tumor Cells
Documentation based on various literature emphasized that fetal mesenchymal stem cells (MSCs) isolated from fetal umbilical cord possess beneficial activity in cancer therapy compared to adult MSCs. This review summarizes the potential interaction of fetal MSCs with tumor cells and their use in clinical protocols. [Curr Stem Cell Res Ther] Abstract

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Cryo-Save Group N.V. Press Release
New management announced a strategy to enter fields of predictive medicine and translational regenerative medicine R&D, the change of the holding company’s name to Esperite, the reorganization of its operations into three separate business units – cord blood and tissue cryo-preservation, proteomics and genomics predictive medicine, and translational regenerative medicine R&D – and the related acquisition of Salveo Biotechnology’s Swiss laboratory and related activities. [Cryo-Save Group N.V.] Press Release

STEMCELL Technologies Inc. Has Just Released NEW MesenCult™ Proliferation Kit with MesenPure™ (Mouse), a Novel Cell Culture Medium to Advance Research on Mouse Mesenchymal Stem and Progenitor Cells (MSCs)
MesenCult™ Proliferation Kit with MesenPure™ (Mouse) is a novel cell culture medium to advance research on mouse mesenchymal stem and progenitor cells (MSCs). [STEMCELL Technologies Inc.] Press Release

$4 Million from Eli and Edythe Broad Foundation Will Support UCLA Research
Two new gifts from The Eli and Edythe Broad Foundation to UCLA totaling $4 million will fund research in stem cell science and digestive diseases and support the recruitment of key faculty at two renowned research centers. [UCLA] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Share the Science with Dr. Joanne Kurtzberg, MD – Cord Blood Transplantation for Genetic and Acquired Brain Diseases: From Blood to Brain
May 19, 11:00AM (CST in US)

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NEW Associate Member – Translational Hematopoietic Cell Gene Therapy and Engineering (Fred Hutchinson Cancer Research Center)

Postdoctoral Researcher – HLA and Non-HLA Genetic Markers in Hematopoietic Stem Cell Transplantation (NHS Blood and Transplant)

Research Associate – Hematopoietic Stem Cell Development (King’s College London)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (The Research Institute, Nationwide Children’s Hospital)

Assistant/Associate Professor – Blood Bank and Transfusion Medicine (University of Virginia Health System)

Postdoctoral Position – Hematopoiesis (Albany Medical Center)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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