Volume 6.19 | May 22

Cord Blood News 6.19 May 22, 2014
Cord Blood News
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A Novel Mutation in Wiskott-Aldrich Syndrome and Successfully Treated with Umbilical Cord Blood Transplantation
Scientists reported a novel mutation in a boy with Wiskott-Aldrich syndrome who was 4 years and 10 months of age and underwent successful umbilical cord blood transplantation. [Blood Cells Mol Dis] Abstract
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Mussel-Inspired Cell-Adhesion Peptide Modification for Enhanced Endothelialization of Decellularized Blood Vessels
Mussel-inspired surface chemistry of polydopamine (pDA) coatings are applied to functionalize decellularized vein matrix (DVM) with extracellular matrix-derived cell adhesion peptides. DVMs engineered with pDA-peptides enhance focal adhesion, metabolic activity, and endothelial differentiation of human endothelial progenitor cells (EPCs) derived from cord blood and embryonic stem cells compared with EPCs on non-coated or pDA-coated DVMs. [Macromol Biosci] Abstract

Expression and Function of Endothelial Selectins during Human Development
Scientists studied the functions of endothelial E- and P-selectins and their counter-receptors during human ontogeny. Real-time imaging using in vitro flow chamber assays showed that cord blood mononuclear leukocytes used E-, P- and L-selectin and PSGL-1 to roll on and adhere to endothelium under physiological shear stress. [Immunology] Abstract

Similar Survival, But Better Quality of Life after Myeloablative Transplantation Using Unrelated Cord Blood vs Matched Sibling Donors in Adults with Hematologic Malignancies
Researchers report no significant differences in the cumulative incidence of grades III to IV acute GvHD, relapse rate, or three-year probabilities of disease-free survival between patients receiving umbilical cord blood transplantation (UCBT) and those receiving peripheral blood stem cells alone or combined with bone marrow. However, the cumulative incidence of chronic and extensive chronic GvHD was lower in UCBT recipients. [Bone Marrow Transplant] Abstract

The Clinical and Financial Burden of Pre-Emptive Management of Cytomegalovirus Disease after Allogeneic Stem Cell Transplantation – Implications for Preventative Treatment Approaches
Investigators compared outcomes and post-transplantation treatment cost in 44 patients who never required pre-emptive cytomegalovirus treatment with 90 treated patients undergoing stem cell transplantation (SCT). Eighty-one subjects received CD34+ selected myeloablative SCT, 12 umbilical cord blood transplants, and 41 T-replete non-myeloablative SCT. [Cytotherapy] Abstract

Neonatal Monocytes Express Antiapoptotic Pattern of Bcl-2 Proteins and Show Diminished Apoptosis Upon Infection with Escherichia coli
Researchers hypothesized that reduced phagocytosis-induced cell death (PICD) in neonatal monocytes is regulated through proteins of the B-cell lymphoma 2 (Bcl-2) protein family. mRNA and protein expression of Bcl-2 family proteins in cord blood and adult peripheral blood monocytes infected with E. coli were analyzed by quantitative real-time PCR and flow cytometry, cytochrome c release by fluorescence microscopy. [Pediatr Res] Abstract

Enhancement of Mouse Germ Cell-Associated Genes Expression by Injection of Human Umbilical Cord Mesenchymal Stem Cells into the Testis of Chemical-Induced Azoospermic Mice
Researchers investigated whether injection of human umbilical cord mesenchymal stem cells into the interstitial compartment of the testes promoted spermatogenic regeneration efficiently. [Asian J Androl] Abstract

Osmotic Tolerance Limits of Red Blood Cells from Umbilical Cord Blood
Researchers aimed to characterize the osmotic tolerance limits of cord red blood cells (RBCs) in conditions relevant to cryopreservation, and compare the results to the osmotic tolerance limits of adult RBCs. [Cryobiology] Abstract

Effect of Influenza A Infection on Maturation and Function of Neonatal Monocyte-Derived Dendritic Cells
Scientists investigated the effect of influenza A virus infection on the maturation, apoptosis, and function of monocyte-derived dendritic cells from umbilical cord blood and compared this with responses from adult peripheral blood. [Viral Immunol] Abstract

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T-Cell Replete Haploidentical Donor Transplantation Using Post-Transplant CY: An Emerging Standard-of-Care Option for Patients Who Lack an HLA-Identical Sibling Donor
In parallel trials using similar non-myeloablative conditioning regimens, HLA-haploidentical donor transplantation that uses T-cell replete grafts and post-transplant CY produced similar overall survival to double umbilical cord blood transplantation in adult patients, with low rates of TRM, severe acute GvHD and chronic GvHD. [Bone Marrow Transplant] Abstract

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Pluristem Receives Clearance from South Korea to Use PLX Cells Manufactured at Its New Facility in Its Advanced Studies
Pluristem Therapeutics Inc. announced the latest advancement in its clinical and commercial development programs in South Korea. The South Korean Ministry of Food and Drug Safety has recently cleared Pluristem’s upgraded manufacturing process in its new facility in Haifa, Israel. The cells produced at Pluristem’s new facility will be used by Korean sites joining the large Phase II study currently conducted by Pluristem in intermittent claudication patients. [Pluristem Therapeutics Inc.] Press Release

Maryland Stem Cell Research Commission Funds 31 New Research Proposals in FY 2014 with Continued Focus on Contributing to Cures for Debilitating Diseases and Conditions
The board of directors of the Maryland Technology Development Corporation approved the Commission’s recommendation to fund 31 new proposals with the Maryland Stem Cell Research Fund’s $10.4 million FY2014 budget. [Maryland Stem Cell Research Fund] Press Release

Gene Therapy Section Formed within the Alliance for Regenerative Medicine
The Alliance for Regenerative Medicine (ARM) and the American Society of Gene & Cell Therapy (ASGCT) announced their partnership. ARM’s new Gene and Gene-Modified Cell Therapy Section brings together the leading gene therapy companies and organizations in the U.S. and Europe to advocate for policies and programs to accelerate the development of new therapeutics to treat and cure a range of diseases for which no effective treatment options are available. [Alliance for Regenerative Medicine] Press Release

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NEW Postdoctoral Fellow – Cell Therapy with Umbilical Mesenchymal Stem Cells (University of Cincinnati)

NEW Postdoctoral Research Scientist – Immunotherapy (The Anthony Nolan Trust)

NEW Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Associate Member – Translational Hematopoietic Cell Gene Therapy and Engineering (Fred Hutchinson Cancer Research Center)

Postdoctoral Researcher – HLA and Non-HLA Genetic Markers in Hematopoietic Stem Cell Transplantation (NHS Blood and Transplant)

Research Associate – Hematopoietic Stem Cell Development (King’s College London)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (The Research Institute, Nationwide Children’s Hospital)

Assistant/Associate Professor – Blood Bank and Transfusion Medicine (University of Virginia Health System)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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