Volume 6.20 | May 29

Cord Blood News 6.20 May 29, 2014
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook  Cord Blood News on Twitter
Differentiating Neurons Derived from Human Umbilical Cord Blood Stem Cells Work as a Test System for Developmental Neurotoxicity
Data confirms that differentiating neuronal cells derived from human umbilical cord stem cells could be used as a powerful tool to assess the developmental neurotoxicity in human beings. [Mol Neurobiol] Abstract
New Cord Banking Software Solution from STEMSOFT
PUBLICATIONS (Ranked by impact factor of the journal)
Human Infra-Patellar Fat Pad-Derived Stromal Cells Have More Potent Differentiation Capacity than Other Mesenchymal Cells and Can Be Enhanced by Hyaluronan
Results showed that the infra-patellar fat pad stromal cells had a higher capacity for chondrogenic differentiation than mesenchymal cells from body fat, bone marrow, and Wharton’s jelly of the umbilical cord. [Cell Transplant] Full Article

Acidic Preconditioning Improves the Proangiogenic Responses of Endothelial Colony Forming Cells
Considering that endothelial colony-forming cells (ECFC) are a subpopulation of CD34+ cells and key players in vasculogenesis, researchers investigated the effect of acidosis on the survival and functionality of ECFC. Endothelial colony-forming cells obtained by differentiation of human cord blood CD34+ cells in endothelial growth medium-2 for 14-21 days were exposed at pH 7.4, 7.0 or 6.6. [Angiogenesis] Abstract

Mismatched Related and Unrelated Donors for Allogeneic Hematopoietic Cell Transplantation for Adults with Hematologic Malignancies
Two parallel Phase II trials in adults with hematologic malignancies demonstrated comparable survival after reduced intensity conditioning and transplantation of either two HLA-mismatched umbilical cord blood units or bone marrow from HLA-haploidentical relatives. [Biol Blood Marrow Transplant] Abstract

Human Placenta Mesenchymal Stem Cells Expressing Exogenous Kringle1-5 Protein by Fiber-Modified Adenovirus Suppress Angiogenesis
Researchers report human placenta-derived mesenchymal stem cell-based gene therapy using a fiber-modified adenoviral vector carrying the kringle1-5 gene to maintain long-term survival and effectively suppress angiogenesis both in vitro and in vivo. [Cancer Gene Ther] Abstract

Osteogenic Differentiation of Umbilical Cord and Adipose Derived Stem Cells onto Highly Porous 45S5 Bioglass®-Based Scaffolds
Investigations concerned the osteogenic cell attachment, growth and differentiation of adipose tissue derived mesenchymal stem cells (MSC) compared with MSC from human full term umbilical cord tissues on porous Bioglass®-based scaffolds over a cultivation period of five weeks. [J Biomed Mater Res A] Abstract

Neonatal Monocytes Express Antiapoptotic Pattern of Bcl-2 Proteins and Show Diminished Apoptosis Upon Infection with Escherichia coli
mRNA and protein expression of B-cell lymphoma 2 (Bcl-2) family proteins in cord blood and adult peripheral blood monocytes infected with E. coli were analyzed by quantitative real-time PCR and flow cytometry, cytochrome c release by fluorescence microscopy. [Pediatr Res] Abstract

Combined Injection of Three Different Lineages of Early Differentiating Human Amniotic Fluid-Derived Cells Restores Urethral Sphincter Function in Urinary Incontinence
Researchers investigated whether a triple combination of early-differentiated cells derived from human amniotic fluid stem cells would show synergistic effects in urethral sphincter regeneration. [BJU Int] Abstract

Effect of Topology of Poly(L-Lactide-co-ε-Caprolactone) Scaffolds on the Response of Cultured Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells and Neuroblastoma Cell Lines
The effect of the surface topology and pore architecture were studied on the biocompatibility for supporting the growth of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells and human neuroblastoma cells as cell models. [J Biomater Sci Polym Ed] Abstract

Acute Funisitis Is Associated with Distinct Changes in Fetal Hematologic Profile
The hematologic profiles of umbilical cord blood obtained at birth were compared according to the presence or absence of acute funisitis in 197 preterm neonates (gestational age before 34 weeks) born to mothers with preterm labor with intact membranes or premature rupture of membranes. [J Matern Fetal Neonatal Med] Abstract

Learn more: StemSpan™ Megakaryocyte Expansion Supplement
Lysosomal Storage Diseases: Stem Cell-Based Cell- and Gene-Therapy
Transplantation of hematopoietic stem cells, bone marrow stem cells and umbilical cord blood-derived stem cells offer effective but limited efficacy for patients suffering from Krabbe disease, mucopolysaccharidosis VII and adrenal leukodystrophy but in other lysosomal storage diseases (LSDs) they are ineffective. Cell-based gene therapies for LSDs bridge the application of enzyme replacement therapy and gene therapy and are important direction to pursue in the future. [Cell Transplant] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.
Pluristem Move Forward in the Orthopedic Area with the Support of Key Opinion Leaders
Pluristem Therapeutics Inc. announced it has enhanced its activity in the orthopedic indications for its PLacental eXpanded cell therapies. In January, Pluristem announced positive results from its Phase I/II clinical trial for the treatment of injured gluteal muscle after total hip arthroplasty. [Pluristem Therapeutics Inc.]
Press Release

Stem Cell Research on Campus Grows after $3 Million Boost
Cornell Stem Cell Program researchers Professor John Schimenti and Nikitin received $3 million from the New York State Stem Cell Science program of the New York State Department of Health to support the Stem Cell Modeling and Phenotyping Core. [Cornell University] Press Release

New wallchart from our sponsor:
Mesenchymal Stem Cells (a Nature Reviews Molecular Cell Biology collaboration). Request your free copy.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Therapy Bioprocessing
September 15-16, 2014
Arlington, United States

NEW Bioprocess International
October 20-23, 2014
Boston, United States

Visit our events page to see a complete list of events in the cord blood community.
NEW Postdoctoral Researcher – Hematopoietic Stem Cells & iPSCs (KU Leuven)

Postdoctoral Fellow – Cell Therapy with Umbilical Mesenchymal Stem Cells (University of Cincinnati)

Postdoctoral Research Scientist – Immunotherapy (The Anthony Nolan Trust)

Associate Member – Translational Hematopoietic Cell Gene Therapy and Engineering (Fred Hutchinson Cancer Research Center)

Research Associate – Hematopoietic Stem Cell Development (King’s College London)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (The Research Institute, Nationwide Children’s Hospital)

Assistant/Associate Professor – Blood Bank and Transfusion Medicine (University of Virginia Health System)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Cord Blood News? Click here to submit!

Comments or suggestions? Submit your feedback here
Learn more about Cord Blood News: Archives | Events | Contact Us