Volume 6.21 | Jun 5

Cord Blood News 6.21 June 5, 2014
Cord Blood News
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Gene Profiling Reveals Association between Altered Wnt Signaling and Loss of T-Cell Potential with Age in Human Hematopoietic Stem Cells
Researchers examined the gene expression profiles of young and aged hematopoietic stem cells (HSCs) from human cord blood and adult mobilized peripheral blood, respectively, and found that Wnt signaling genes are differentially expressed between young and aged human HSCs, with less activation of Wnt signaling in aged HSCs. [Aging Cell] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
CD4 T Cells with Effector Memory Phenotype and Function Develop in the Sterile Environment of the Fetus
Researchers identified and characterized a population of fetally developed CD4 T cells with an effector memory phenotype, which are present in cord blood. [Sci Transl Med] Abstract

A Motif in LILRB2 Critical for Angptl2 Binding and Activation
Scientists demonstrated that Angptl2 expressed in mammalian cells forms high molecular weight species, and ligand multimerization is required for activation of LILRB2 for downstream signaling. Immobilized anti-LILRB2 antibodies induce a more potent activation of LILRB2 than Angptl2, and they developed a serum-free culture containing defined cytokines and immobilized anti-LILRB2 that supports a net expansion of repopulating human cord blood hematopoietic stem cells. [Blood] Abstract

Low Dose Insulin Like Growth Factor Binding Proteins 1 and 2 and Angiopoietin Like Protein 3 Coordinately Stimulate Ex Vivo Expansion of Human Umbilical Cord Blood Hematopoietic Stem Cells as Assayed in NOD/SCID Gamma Null Mice
In order to determine the optimal dose and combination of insulin like growth factors (IGFs), IGF binding proteins (IGFBPs) and angiopoietin like proteins (ANGPTLs), serial dilution and full permutation of IGFBP1, IGFBP2, IGF2 and ANGPTL3 were applied on cryopreserved umbilical cord blood mononuclear cells ex vivo expansion system. [Stem Cell Res Ther] Abstract | Full Article

Umbilical Cord Blood Transplantation and Unmanipulated Haploidentical Hematopoietic SCT for Pediatric Hematologic Malignances
Investigators aimed to compare the therapeutic effects of single umbilical cord blood transplantation and unmanipulated haploidentical hematopoietic SCT in childhood hematologic malignances. [Bone Marrow Transplant] Abstract

Autoimmune Cytopenias after Umbilical Cord Blood Transplantation in Adults with Hematological Malignancies: A Single-Center Experience
Scientists described incidence, clinical features, serological data, response to therapy and outcome of autoimmune cytopenias, including autoimmune hemolytic anemia and autoimmune thrombocytopenia in a series of 281 consecutive adults with hematological malignancies that received single-unit umbilical cord blood transplantation at a single institution. [Bone Marrow Transplant] Abstract

Optimizing Isolation Culture and Freezing Methods to Preserve Wharton’s Jelly’s Mesenchymal Stem Cell (MSC) Properties: An MSC Banking Protocol Validation for the Hellenic Cord Blood Bank
Investigators aimed to assess the optimal isolation and cryopreservation procedures to facilitate Wharton’s jelly (WJ) MSC banking. Cells were isolated from umbilical cord-WJ using enzymatic digestion or plastic adhesion methods. Their isolation efficacy, growth kinetics, immunophenotype, and differentiation potential were studied, as well as the effects of freezing. [Transfusion] Abstract

Stem Cell Treatment after Cerebral Ischemia Regulates the Gene Expression of Apoptotic Molecules
Researchers hypothesized that intravenous administration of human umbilical cord blood-derived mesenchymal stem cells after focal cerebral ischemia would reduce brain damage by inhibiting apoptosis and downregulating the upregulated apoptotic pathway molecules. [Neurochem Res] Abstract

Multicolor Staining of Globin Subtypes Reveals Impaired Globin Switching during Erythropoiesis in Human Pluripotent Stem Cells
To examine the mechanism of impaired globin switching, the authors optimized multicolor flow cytometry to simultaneously follow expression of different globin subtypes using different immunofluorescent probes. This enabled them to detect upregulation of β-globin and the corresponding silencing of γ-globin at the single-cell level during cord blood CD34+ cell-derived erythropoiesis, examined as an endogenous control. [Stem Cells Transl Med] Abstract

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Current Thawing and Infusion Practice of Cryopreserved Cord Blood: The Impact on Graft Quality, Recipient Safety, and Transplantation Outcomes
This review compares currently available cord blood (CB) product types and thaw methods recommended by CB banks, discusses causes of inconsistency in thaw method application at thaw/transplant centers (TCs), advises elements to consider in thaw method approval or selection at the TC, provides a procedural template for the traditional thaw methods, and suggests acceptable time from product thaw to infusion and other considerations for safe infusion. [Transfusion] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
Fate Therapeutics to Highlight Potential Clinical Applications of Ex Vivo Hematopoietic Cell Modulation
Fate Therapeutics, Inc. announced that potential clinical applications of its ex vivo approach to pharmacologically modulating hematopoietic cells will be presented. [Press release from Fate Therapeutics, Inc. discussing research to be presented at the 12th Annual International Cord Blood Symposium, San Francisco] Press Release

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Insception Lifebank Cord Blood Program Launches Cord Tissue Banking
Insception Lifebank, Canada’s largest cord blood program, now offers expecting parents the option to bank a section of the actual umbilical cord tissue, in addition to banking cord blood. [Vocus PRW Holdings, LLC]
Press Release

UCLA Stem Cell Researcher Receives $5.1 Million Award from State Agency
California’s state stem cell agency has given UCLA’s Dr. John Chute a Research Leadership Award worth $5.1 million to support his research aimed at creating new stem cell therapies for use in medical practice. His groundbreaking research focuses on hematopoietic stem cells, the cells that become blood cells, and how they grow. [UCLA] Press Release

William Gerber, MD. Appointed CEO at SynGen Inc.
SynGen Inc., a company focused on the development and commercialization of instrument systems that harvest stem and progenitor cells from umbilical cord blood, bone marrow, peripheral blood, and cell culture, announced that Dr. William Gerber has been appointed CEO to replace co-founder and lead inventor Philip Coelho. [SynGen Inc.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 2014 International Society for the Cell and Gene Therapy of Cancer (ISCGT) Annual Meeting
September 25-27, 2014
Amsterdam, The Netherlands

Visit our events page to see a complete list of events in the cord blood community.
NEW Research Associate – Hematology/Oncology (University of Chicago)

Postdoctoral Researcher – Hematopoietic Stem Cells & iPSCs (KU Leuven)

Postdoctoral Fellow – Cell Therapy with Umbilical Mesenchymal Stem Cells (University of Cincinnati)

Postdoctoral Research Scientist – Immunotherapy (The Anthony Nolan Trust)

Associate Member – Translational Hematopoietic Cell Gene Therapy and Engineering (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellowship – Hematology, Immunology, Cancer Therapeutics (The Research Institute, Nationwide Children’s Hospital)

Assistant/Associate Professor – Blood Bank and Transfusion Medicine (University of Virginia Health System)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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