Volume 6.23 | Jun 19

Cord Blood News 6.23 June 19, 2014
Cord Blood News
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Human Umbilical Cord Blood- Derived Mesenchymal Stem Cells Producing IL-15 Eradicate Established Pancreatic Tumor in Syngeneic Mice
Human mesenchymal stem cells (MSCs) were isolated from umbilical cord blood as delivery vehicles, and transduced with lentivirus vector expressing murine interleukin-15 (IL-15). In vitro assays of lymphocyte activation and proliferation demonstrated that IL-15 produced by MSCs was biofunctional. [Mol Cancer Ther] Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Sequential Myeloablative Autologous Stem Cell Transplantation and Reduced Intensity Allogeneic Hematopoietic Cell Transplantation Is Safe and Feasible in Children, Adolescents and Young Adults with Poor Risk Refractory or Recurrent Hodgkin and Non-Hodgkin Lymphoma
Investigators conducted a multi-center prospective study of myeloablative conditioning and autologous stem cell transplantation, followed by a reduced intensity conditioning and allogeneic hematopoietic cell transplantation in children, adolescents and young adults, with poor risk refractory or recurrent lymphoma. Allogeneic donor sources included unrelated cord blood, unrelated donor and matched siblings. [Leukemia] Abstract

Gene Transfer Properties and Structural Modeling of Human Stem Cell-Derived AAV
Researchers reported for the first time, the presence of novel AAV variants in healthy CD34+ human peripheral blood stem cells. Gene transfer vectors derived from these novel AAVs efficiently underwent entry and post-entry processing in human cord blood stem cells and supported stable gene transfer into long-term, in vivo engrafting human HSCs significantly better than other serotypes. [Mol Ther] Abstract

B7 Costimulation and Intracellular Indoleamine 2,3-Dioxygenase (IDO) Expression in Umbilical Cord Blood and Adult Peripheral Blood
Scientists determined the frequency of activated (CD11b+) monocytes expressing B7-1, B7-2, B7-H1, and B7-H2, and that of T cells and CD4+ T helper cells expressing CD28, CTLA-4, PD-1, and ICOS in umbilical cord blood and adult peripheral blood samples using flow cytometry. [Biol Blood Marrow Transplant] Abstract

Unrelated Cord Blood Transplantation for Patients with Primary or Secondary Myelofibrosis
To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis, the authors evaluated 35 UCBT reported to Eurocord. [Biol Blood Marrow Transplant] Abstract

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells
Researchers described a method to generate a human blood brain barrier model using cord blood-derived hematopoietic stem cells. [PLoS One] Full Article

The Effect of Anticoagulant Choice on Collection of Cord Blood
The authors compared cord blood samples exposed to either lyophilized heparin or CPD during collection and a simulated transit period thereafter. [Transfusion] Abstract

Using Human Umbilical Cord Cells for Tissue Engineering: A Comparison with Skin Cells
Researchers placed epithelial cells and Wharton’s jelly cells from the umbilical cord in the context of a reconstructed skin substitute in combination with skin keratinocytes and fibroblasts. They compared the ability of the epithelial cells from both sources to generate a stratified, differentiated skin-like epithelium upon exposure to air when cultured on the two stromal cell types. [Differentiation] Abstract

Functional Characterization of Histamine H4 Receptor on Human Mast Cells
Investigators determined the expression of H4R in human mast cells (HMC-1, LAD-2 and primary cord blood derived CD34+ human mast cells) and characterized its functional properties. [Mol Immunol] Abstract

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Neonatal Platelets: Mediators of Primary Hemostasis in the Developing Hemostatic System
Much of the current knowledge of neonatal platelet function has been based on studies from cord blood samples. Studies suggest that cord blood-derived platelets, as a surrogate for neonatal platelets, are hypo-functional when compared to adult platelets. This review provides an appraisal of the distinct functional phenotype of neonatal platelets. [Pediatr Res] Abstract

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$15 Million Award to Go Toward Exploring New Treatments for Autism, Other Brain Disorders
Duke Medicine has been awarded $15 million to support an innovative research program that explores the use of umbilical cord blood cells to treat autism, stroke, cerebral palsy and related brain disorders. [Duke University Health System] Press Release

Pluristem Granted Patent in Russia for Treatment of Inflammatory Bowel Disease Using Placenta-Derived Cells
Pluristem Therapeutics Inc. announced that Russia’s Federal Service for Intellectual Property has granted to Pluristem Patent No. 2515156 titled, “Methods of Treating Inflammatory Colon Diseases”. The patent covers methods for treating ulcerative colitis or Crohn’s disease using placenta-derived cells. This patent has already been issued to Pluristem in South Africa and is currently pending in several other jurisdictions. [Pluristem Therapeutics Inc.] Press Release

Pluristem Receives Patent in India for Cell Therapy Production Methods and Compositions
Pluristem Therapeutics Inc. announced it has been granted Patent No. 261087 from India’s Office of the Controller General of Patents, Designs & Trade Marks for a patent titled, “Methods for Cell Expansion and Conditioned Media Produced Thereby for Therapy.” [Pluristem Therapeutics Inc.] Press Release

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NEW Stem Cell Meeting on the Mesa
October 7-9, 2014
La Jolla, United States

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NEW Clinical HSCT Faculty Position (University of Wisconsin School of Medicine and Public Health)

NEW Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

NEW Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Postdoctoral Position – Hematopoietic Stem Cell Research (UT Southwestern Medical Center at Dallas)

Postdoctoral Researcher – Novel PSC-Based Blood Therapeutics (Fred Hutchinson Cancer Research Center)

Research Associate – Hematology/Oncology (University of Chicago)

Postdoctoral Researcher – Hematopoietic Stem Cells & iPSCs (KU Leuven)

Postdoctoral Fellow – Cell Therapy with Umbilical Mesenchymal Stem Cells (University of Cincinnati)

Postdoctoral Research Scientist – Immunotherapy (The Anthony Nolan Trust)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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