|PUBLICATIONS (Ranked by impact factor of the journal)|
Sequential Myeloablative Autologous Stem Cell Transplantation and Reduced Intensity Allogeneic Hematopoietic Cell Transplantation Is Safe and Feasible in Children, Adolescents and Young Adults with Poor Risk Refractory or Recurrent Hodgkin and Non-Hodgkin Lymphoma|
Investigators conducted a multi-center prospective study of myeloablative conditioning and autologous stem cell transplantation, followed by a reduced intensity conditioning and allogeneic hematopoietic cell transplantation in children, adolescents and young adults, with poor risk refractory or recurrent lymphoma. Allogeneic donor sources included unrelated cord blood, unrelated donor and matched siblings. [Leukemia]
Gene Transfer Properties and Structural Modeling of Human Stem Cell-Derived AAV
Researchers reported for the first time, the presence of novel AAV variants in healthy CD34+ human peripheral blood stem cells. Gene transfer vectors derived from these novel AAVs efficiently underwent entry and post-entry processing in human cord blood stem cells and supported stable gene transfer into long-term, in vivo engrafting human HSCs significantly better than other serotypes. [Mol Ther]
B7 Costimulation and Intracellular Indoleamine 2,3-Dioxygenase (IDO) Expression in Umbilical Cord Blood and Adult Peripheral Blood
Scientists determined the frequency of activated (CD11b+) monocytes expressing B7-1, B7-2, B7-H1, and B7-H2, and that of T cells and CD4+ T helper cells expressing CD28, CTLA-4, PD-1, and ICOS in umbilical cord blood and adult peripheral blood samples using flow cytometry. [Biol Blood Marrow Transplant]
Unrelated Cord Blood Transplantation for Patients with Primary or Secondary Myelofibrosis
To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis, the authors evaluated 35 UCBT reported to Eurocord. [Biol Blood Marrow Transplant]
A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells
Researchers described a method to generate a human blood brain barrier model using cord blood-derived hematopoietic stem cells. [PLoS One]
The Effect of Anticoagulant Choice on Collection of Cord Blood
The authors compared cord blood samples exposed to either lyophilized heparin or CPD during collection and a simulated transit period thereafter. [Transfusion]
Using Human Umbilical Cord Cells for Tissue Engineering: A Comparison with Skin Cells
Researchers placed epithelial cells and Wharton’s jelly cells from the umbilical cord in the context of a reconstructed skin substitute in combination with skin keratinocytes and fibroblasts. They compared the ability of the epithelial cells from both sources to generate a stratified, differentiated skin-like epithelium upon exposure to air when cultured on the two stromal cell types. [Differentiation]
Functional Characterization of Histamine H4 Receptor on Human Mast Cells
Investigators determined the expression of H4R in human mast cells (HMC-1, LAD-2 and primary cord blood derived CD34+ human mast cells) and characterized its functional properties. [Mol Immunol]
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Neonatal Platelets: Mediators of Primary Hemostasis in the Developing Hemostatic System|
Much of the current knowledge of neonatal platelet function has been based on studies from cord blood samples. Studies suggest that cord blood-derived platelets, as a surrogate for neonatal platelets, are hypo-functional when compared to adult platelets. This review provides an appraisal of the distinct functional phenotype of neonatal platelets. [Pediatr Res]
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