Volume 6.24 | Jun 26

Cord Blood News 6.24 June 26, 2014
Cord Blood News
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HucMSC-Exosome Mediated -Wnt4 Signaling Is Required for Cutaneous Wound Healing
The authors examined the benefit of human umbilical cord mesenchymal stem cell derived exosome (hucMSC-Ex) in cutaneous wound healing using a rat skin burn model. They found that hucMSC-Ex-treated wounds exhibited significantly accelerated re-epithelialization, with increased expression of CK19, PCNA, collagen I (compared to collagen III) in vivo. [Stem Cells] Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Transplant-Acquired Food Allergy (TAFA) following Cord Blood Stem Cell Transplantation in Two Adult Patients with Hematological Malignancies
The authors report two adult patients who developed food allergy several months after having a T-replete cord blood stem cell transplantation (CBSCT). Both patients were included in the reduced intensity conditioning CBSCT trial, and they performed subset analysis of B cell and CD3+, CD4+, CD8+ T cell numbers at 1, 2, 3, 6, 12 and 24 months post-transplant. [Br J Haematol] Full Article

Establishment of Human Cell Type-Specific iPS Cells with Enhanced Chondrogenic Potential
The authors report the generation of new induced pluripotent stem (iPS) cells, which they derived from human articular chondrocytes and from cord blood mononucleocytes via lentiviral-mediated delivery of Oct4, Klf4, Sox2, and cMyc. [Stem Cell Rev] Abstract

Modified Simple Limbal Epithelial Transplantation Using Cryo-Preserved Amniotic Membrane for Unilateral Limbal Stem Cell Deficiency
Researchers report the results of simple limbal epithelial transplantation using a double layered cryo-preserved amniotic membrane graft for the management of unilateral limbal stem cell deficiency. [Am J Ophthalmol] Abstract

Endothelium-Derived Nitric Oxide (NO) Activates the NO-Epidermal Growth Factor Receptor-Mediated Signaling Pathway in Bradykinin-Stimulated Angiogenesis
NO-mediated stimulatory effects on tyrosine phosphorylation of the EGF-R, where cGMP independent. Inhibition of soluble guanylyl cyclase followed by bradykinin stimulation of human umbilical vein endothelial cells did not change tyrosine phosphorylation levels of EGF-R. [Arch Biochem Biophys] Abstract

Distinct Adipogenic Differentiation Phenotypes of Human Umbilical Cord Mesenchymal Cells Dependent on Adipogenic Conditions
Researchers tested the potential of three well-established adipogenic cocktails containing IBMX, dexamethasone, and insulin plus indomethacin or rosiglitazone to stimulate adipocyte differentiation in umbilical cord mesenchymal stem cells. [Exp Biol Med] Abstract

Involvement of Gene Methylation Changes in the Differentiation of Human Amniotic Epithelial Cells into Islet-Like Cell Clusters
Investigators induced human amniotic epithelial cells to differentiate into islet-like cell clusters by nicotinamide plus betacellulin in vitro, and further investigated the DNA methylation status by a Nimble MeDIP microarray before and after cell differentiation to shed light on the molecular mechanisms of this differentiation. [DNA Cell Biol] Abstract

BMP4 Promotes SSEA-1+ hUC-MSC Differentiation into Male Germ-Like Cells In Vitro
Whether human umbilical cord mesenchymal stem cells (hUC-MSCs) can be induced to differentiate into germ-like cells with the aid of bone morphogenetic protein (BMP4) was investigated. [Cell Prolif] Abstract

Sustained Expression of Coagulation Factor IX by Modified Cord Blood-Derived Mesenchymal Stromal Cells
Modification of human CB mesenchymal stromal cells with a lentiviral vector resulted in sustained high Factor IX expression in vitro following differentiation to adipogenic, chondrogenic and osteoblastic cells. [J Gene Med] Abstract

Effects of Sex Hormones on Inflammatory Response in Male and Female Vascular Endothelial Cells
Investigators compare the effects of sex hormones on inflammatory response in human umbilical vein endothelial cells obtained from both male and female donors. [J Endocrinol Invest] Abstract

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Next Generation Treatment of Acute Graft-versus-Host Disease
New insights into the roles played by novel cytokines, chemokines, intracellular signaling pathways, epigenetics and post translational modifications of proteins in graft-versus-host disease (GvHD) biology provide numerous targets that might be therapeutically exploited. This review highlights recent advances and identifies opportunities for reshaping contemporary GvHD therapeutics. [Leukemia] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

BioProcess International Conference & Exhibition - Boston MA
Pluristem Selects Rotator Cuff Repair as New Orthopedic Indication
Pluristem Therapeutics Inc. announced it has selected rotator cuff repair as the second indication in its orthopedic clinical program. The company’s placental expanded cells offer potential as the first off-the-shelf cell therapy product for muscle and tendon regeneration that can be used to enhance repair after rotator cuff surgery. [Pluristem Therapeutics Inc.] Press Release

MacroGenics Initiates Phase I Study of MGD006 for the Treatment of Acute Myeloid Leukemia
MacroGenics, Inc. announced that a first patient received drug in a Phase I study of MGD006 in relapsed or refractory acute myeloid leukemia. MGD006 is a humanized, Dual-Affinity Re-Targeting (DART®) bi-specific antibody-based molecule that binds to both CD123 and CD3, antigens expressed on leukemic cells and T lymphocytes, respectively. This study marks the first clinical trial of a DART product candidate. [MacroGenics, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW World Cord Blood Congress 2014
September 15-16, 2014
Boston, United States

Visit our events page to see a complete list of events in the cord blood community.
NEW Grant Writer – Pediatric Hematology, Oncology, Stem Cell Transplant, and Cancer Biology (Stanford University School of Medicine)

NEW Cord Tissue Processing Technician (Cord Blood Registry)

Clinical HSCT Faculty Position (University of Wisconsin School of Medicine and Public Health)

Postdoctoral Position – Hematopoietic Stem Cell Research (UT Southwestern Medical Center at Dallas)

Postdoctoral Researcher – Novel PSC-Based Blood Therapeutics (Fred Hutchinson Cancer Research Center)

Research Associate – Hematology/Oncology (University of Chicago)

Postdoctoral Researcher – Hematopoietic Stem Cells & iPSCs (KU Leuven)

Postdoctoral Fellow – Mammalian Hematopoietic and Erythroid Development (The Icahn School of Medicine at Mount Sinai)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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