Volume 6.32 | Aug 21

Cord Blood News 6.32 August 21, 2014
Cord Blood News
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Molecular Pathways Reflecting Poor Intrauterine Growth Are Found in Wharton’s Jelly-Derived Mesenchymal Stem Cells
Mesenchymal stem cells from small for gestational age newborns were found to express an altered EGR-1-dependent gene network involved in the regulation of cell proliferation and oxidative stress. [Hum Reprod] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Thrombopoietin Treatment of One Graft in a Double Cord Blood Transplant Provides Early Platelet Recovery while Contributing to Long Term Engraftment in NSG Mice
Using a double cord blood (CB) murine transplant model, scientists investigated whether thrombopoietin cultured human CB CD34+ cells have a competitive advantage or disadvantage over untreated human CB CD34+ cells in terms of short and longer term platelet recovery and longer term hematological recovery. [Stem Cells Dev] Abstract

Systemic Injection of CD34+ Enriched Human Cord Blood Cells Modulates Post-Stroke Neural and Glial Response in a Sex-Dependent Manner in CD1 Mice
Investigators determined the impact of human cord blood derived CD34+-enriched mononuclear cells injected intraperitoneally on post-stroke neurogenic niche proliferation, glial response, and recovery in CD1 mice, when injected 48 hours after an ischemic insult at post-natal day 12. [Stem Cells Dev] Abstract

Induction of Highly Functional Hepatocytes from Human Umbilical Cord Mesenchymal Stem Cells by HNF4α Transduction
Researchers investigated the differentiation potential of human umbilical mesenchymal stem cells and the key factors that facilitate hepatic differentiation. [PLoS One] Full Article

The Effect of Conditioned Medium Derived from Human Placental Multipotent Mesenchymal Stromal Cells on Neutrophils: Possible Implications for Placental Infection
Scientists hypothesized that human placental multipotent mesenchymal stromal cells (hPMSCs) are involved in the early phases of bacterial infection. hPMSCs were isolated from term placentas and neutrophils from peripheral blood. [Mol Hum Reprod] Abstract

Inner Ear Stem Cells Derived Feeder Layer Promote Directional Differentiation of Amniotic Fluid Stem Cells into Functional Neurons
Scientists investigated the effect of inner ear stem cells derived feeder layer on amniotic fluid stem cells differentiation in vitro. An inner ear stem cells derived feeder layer direct contact system was established to induce differentiation of amniotic fluid stem cells. [Hear Res] Abstract

The Effects of Gremlin1 on Human Umbilical Cord Blood Hematopoietic Progenitors
Investigators examined the effects of Gremlin1 on long-term culture-initiating cells and transplantable hematopoietic stem cells in human umbilical cord blood. Gremlin1 inhibited BMP signaling, downregulated BMP-6 and cyclin E2 expression and upregulated hairy and enhancer of split-1 and Hedgehog interacting protein-1. [Blood Cells Mol Dis] Abstract

Over-Expression of Oct4 and Sox2 Transcription Factors Enhances Differentiation of Human Umbilical Cord Blood Cells In Vivo
Utilizing genetically modified human umbilical cord blood mono-nuclear cells, researchers report enhanced differentiation of transplants in a mouse model of amyotrophic lateral sclerosis. [Biochem Biophys Res Commun] Abstract

Allogeneic Mesenchymal Stem Cell Transplantation for Lupus Nephritis Patients Refractory to Conventional Therapy
In an open-label and single-center clinical trial, 81 Chinese patients with active and refractory lupus nephritis were enrolled. Allogeneic bone marrow- or umbilical cord-derived mesenchymal stem cells were administered intravenously at the dose of one million cells per kilogram of bodyweight. [Clin Rheumatol] Abstract

Construction of Corneal Epithelium with Human Amniotic Epithelial Cells and Repair of Limbal Deficiency in Rabbit Models
Investigators evaluated the effect of a human amniotic epithelial cell-rabbit corneal stroma tissue-engineered cornea on ocular reconstruction in three different animal models. [Hum Cell] Abstract

Take the "if" out of "diff": Reduce variability when differentiating to hematopoietic cells
The Role of Telomeres and Telomerase in Hematologic Malignancies and Hematopoietic Stem Cell Transplantation
The characteristics and roles of telomeres and telomerase both in hematologic malignancies and in hematopoietic stem cell transplantation is summarized. The current status of telomerase-targeted therapies utilized in the treatment of hematologic malignancies is also reviewed. [J Hematol Oncol] Abstract | Full Article

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$15 Million Marcus Grant Boosts Cord Blood Research
Duke University has received a $15 million grant from The Marcus Foundation for research focused on umbilical cord blood cells to treat autism, stroke and other neurological disorders. [North Carolina Biotechnology Center] Press Release

Expression Therapeutics LLC Selects ABL, Inc. to Support Cell Line Development for Hemophilia A Factor VIII Infusion Therapy
Expression Therapeutics LLC together with ABL, Inc. announced an agreement whereby ABL will perform cell line development studies to improve manufacturability and reduce the costs associated with large-scale production of recombinant factor VIII replacement therapy. [Expression Therapeutics LLC (Business Wire)] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 21st Stem Cell Network Workshop – Bioengineering and Stem Cells
September 23, 2014
Sydney, Australia

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NEW Postdoctoral Positions – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Postdoctoral Positions – Hematologic Malignancies and Cellular Therapy (Duke University Department of Medicine)

Postdoctoral Fellow – Hematopoietic Stem Cells and Signaling Transduction (University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia)

Postdoctoral Fellowship – Developing Applications of Mesenchymal Stromal/Stem Cells in Hematopoietic Cell Transplantation (The Research Institute at Nationwide Children’s Hospital)

Postdoctoral Positions – Reprogramming and Genetic Engineering Technologies to Develop New Models of Hematopoiesis and Hematopoietic Disorders (Icahn School of Medicine)

Hematopoietic Stem Cell Scientist – Human Genetic Disorders (Editas Medicine)

Postdoctoral Researcher – Hematopoietic Stem Cell Maintenance (Baylor College of Medicine)

Cord Tissue Processing Technician (Cord Blood Registry)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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