Volume 6.38 | Oct 2

Cord Blood News 6.38 October 2, 2014
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Circadian and Circannual Variations in Cord Blood Hematopoietic Cell Composition
The authors observed that gestational age, birth weight and baby’s gender impacted concentrations of nucleated and hematopoietic progenitor cells in cord blood. They also show that uses of epidural anesthesia and of oxytocin were associated with higher concentrations of hematopoietic progenitor cells. [Haematologica]
Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Identification and Clinical Relevance of Naturally Occurring Human CD8+HLA-DR+ Regulatory T Cells
Scientists show that CD8+ T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8+ regulatory T cell subset. [J Immunol] Abstract

Human CD133-Positive Hematopoietic Progenitor Cells Initiate Growth and Metastasis of Colorectal Cancer Cells
CD133+ human hematopoietic progenitor cells (HUHPCs) were purified from human umbilical cord blood and expanded in vitro. Scientists studied the effects of CD133+ HUHPCs on the growth and metastasis of four colorectal cancer cell lines by using cell-to-cell co-culture. [Carcinogenesis] Abstract

Role of Gamma-Secretase in Human Umbilical-Cord Derived Mesenchymal Stem Cell Mediated Suppression of NK Cell Cytotoxicity
Umbilical cord derived mesenchymal stem cells could potently suppress natural killer (NK) cell cytotoxicity in overnight cultures via soluble factors. The main soluble immunosuppressant was identified as prostaglandin-E2. [Cell Commun Signal] Abstract | Full Article

Diet Composition Transiently Modulates Proliferative and Potency Features of Human Cord Blood-Derived Mesenchymal Stem Cells
Scientists compared the effects during culture of two different mesenchymal stem cell (MSC) commercial media on the proliferative capacities, phenotypic and molecular features in human cord blood derived-MSC lines. [Int J Biochem Cell Biol] Abstract

S100A6 Is Secreted from Wharton’s Jelly Mesenchymal Stem Cells and Interacts with Integrin β1
Using mesenchymal stem cells isolated from Wharton’s jelly of the umbilical cord, researchers showed that S100A6 is secreted by these cells, and when added to the medium, increases their adhesion and inhibits proliferation. [Int J Biochem Cell Biol] Abstract

Bone Marrow Stromal Cells Transduced with a Thrombopoietin, Interleukin-6, and Interleukin-11 Syncretic Gene Induce Cord Mononuclear Cells to Generate Platelets In Vitro
The thrombopoietin, interleukin (IL)-6, and IL-11 genes, three regulatory factors important for thrombopoiesis, were used to construct self-splicing fusion genes linked by foot and mouth disease and Theiler’s murine encephalitis viruses. Bone marrow stromal cells transduced with the fusion gene acted as nourishing cells and induced cord blood mononuclear cells to generate platelets in vitro. [Transfusion] Abstract

Impact of Long Term Cryopreservation on Single Umbilical Cord Blood Transplant Outcomes
The authors sought to determine the effect of umbilical cord blood (UCB) unit cryopreservation time on hematopoietic potency. They analyzed 288 single UCB units used for transplantation. [Biol Blood Marrow Transplant] Abstract

Amniotic Fluid-Derived Stem Cells Demonstrated Cardiogenic Potential in Indirect Co-Culture with Human Cardiac Cells
Investigators examined human amniotic fluid-derived stem cell cardiogenic potential in indirect co-culture with human cardiac cells in conditions that eliminated the possibility of cell fusion. [Ann Biomed Eng] Abstract

Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Myelodysplastic Syndromes: A Multicenter Experience from Argentina
A retrospective analysis of 54 allogeneic hematopoietic stem cell transplantations was carried out in 52 patients. Donors were related in 32 cases and the stem cells sources were: bone marrow, peripheral blood, and umbilical cord blood. [Pediatr Blood Cancer] Abstract

Early Umbilical Cord Blood-Derived Stem Cell Transplantation Does Not Prevent Neurological Deterioration in Mucopolysaccharidosis Type III
Researchers report on the five-year outcome of early transplantation, i.e., before onset of clinical neurological disease, in combination with the use of umbilical cord blood-derived hematopoietic stem cells, in two mucopolysaccharidosis type III patients. [JIMD Rep] Abstract

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REVIEWS
The Potential of Wharton’s Jelly Derived Mesenchymal Stem Cells in Treating Patients with Cystic Fibrosis
Wharton’s jelly-derived mesenchymal stem cells (MSCs) from non-cystic fibrosis (CF) carrier third-party donors could be an effective alternative to bone marrow or embryonic stem cells. The authors discuss the clinical potential of MSCs in CF patients. [Adv Exp Med Biol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
INDUSTRY NEWS
CORD:USE Is Pleased to Announce It Has Partnered with Tianhe Stem Cell Biotechnologies
CORD:USE Cord Blood Bank announced that it has entered into an Equity and Exclusive Services Agreement with Tianhe Stem Cell Biotechnologies, Inc. which has licensed a series of patented technologies for the isolation of human cord blood-derived multipotent stem cells for possible clinical applications. [CORD:USE Cord Blood Bank, Inc. (PR Newswire Association LLC)] Press Release

Cesca Therapeutics Announces Approval of Its AXP® AutoXpress® System in Taiwan
Cesca Therapeutics Inc. announced that the company has received approval from the Taiwan Food and Drug Administration for the sale and distribution of its AXP AutoXpress System and related cell processing bag-set in Taiwan. [Cesca Therapeutics Inc. (GlobeNewswire, Inc.)] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 4th Pan-European Conference on Hemoglobinopathies and Rare Anemias 2014
November 7-9, 2014
Athens, Greece

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Molecular Mechanisms of Hematopoiesis and Blood Disorders (St. Jude Children’s Research Hospital)

NEW Postdoctoral Positions – Models of Myelodysplastic Syndromes, Leukemia and Inherited Bone Marrow Failure (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – Cell Signaling in Hematopoietic Stem Cells (Cincinnati Children’s Hospital Medical Center)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Fellow – Hematopoietic Stem Cells and Signaling Transduction (University of Pennsylvania)

Postdoctoral Positions – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Postdoctoral Positions – Hematologic Malignancies and Cellular Therapy (Duke University Department of Medicine)

Cord Tissue Processing Technician (Cord Blood Registry)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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