Volume 6.40 | Oct 16

Cord Blood News 6.40 October 16, 2014
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Researchers Develop New Cells Meant to Form Blood Vessels, Treat Peripheral Artery Disease
Researchers have developed a technique to jump-start the body’s systems for creating blood vessels, opening the door for potential new treatments for diseases whose impacts include amputation and blindness. They developed a novel methodology to mature the induced pluripotent stem cells into cells with the characteristics of the endothelial colony-forming cells that are found in umbilical cord blood. [Press release from the Indiana University School of Medicine discussing publication in Nature Biotechnology] Press Release | Abstract | Video
25% Off First Order: MNCs, CD34+ cells and more! Expires October 31st, 2014
 
PUBLICATIONS (Ranked by impact factor of the journal)
Overexpression of ERG in Cord Blood Progenitors Promotes Expansion and Recapitulates Molecular Signatures of High ERG Leukemias
Human CD34+ cells were transduced with retroviral vectors to elevate ERG gene expression to levels detected in high ERG acute myeloid leukemia. RNA sequencing was performed on purified populations of transduced cells to define the effects of high ERG on gene expression in human CD34+ cells. [Leukemia] Abstract

Prenatal Arsenic Exposure and the Epigenome: Identifying Sites of 5-Methyl Cytosine Alterations that Predict Functional Changes in Gene Expression in Newborn Cord Blood and Subsequent Birth Outcomes
Scientists examined a subset of newborn cord blood leukocyte samples collected from mothers enrolled in the Biomarkers of Exposure to Arsenic pregnancy cohort in Gómez Palacio, Mexico who were exposed to a range of drinking water arsenic concentrations. [Toxicol Sci] Abstract

Targeted Transplantation of Human Umbilical Cord Blood Endothelial Progenitor Cells with Immunomagnetic Nanoparticles to Repair Corneal Endothelium Defect
Human umbilical cord blood endothelial progenitor cells were labeled with CD34 immunomagnetic nanoparticles. The efficiency of the magnet attraction was evaluated in vitro with a simple device simulating the anterior chamber. [Stem Cells Dev] Abstract

Temporal Studies into Attachment, VE-Cadherin Perturbation and Paracellular Migration of Human Umbilical Mesenchymal Stem Cells across Umbilical Vein Endothelial Monolayers
Scientists investigated the dynamic interactions between mesenchymal stem cells from human term umbilical cords (WJ-MSC) and umbilical vein endothelial cells, including attachment, transit times, extravasation pathway and the effects of WJ-MSC on junctional VE-cadherin. [Stem Cells Dev] Abstract

Human Wharton’s Jelly-Derived Stem Cells Display Immunomodulatory Properties and Transiently Improve Rat Experimental Autoimmune Encephalomyelitis
Scientists investigated whether Wharton’s jelly-derived stromal cells possess the required properties to effectively and durably reverse the pathological hallmarks of multiple sclerosis, and whether they survive in an inflammatory environment after transplantation. [Cell Transplant] Full Article

Complete Nationwide Survey on Umbilical Cord Blood Freezing Bag Breakage in Japan
Although umbilical cord blood (UCB) has now become a common stem cell source, UCB bag breakage is a known risk in UCB transplantation. The authors provide the first comprehensive data on the frequency and causes of UCB bag breakage in Japan. [Cytotherapy] Abstract

Transplantation of Human Umbilical Mesenchymal Stem Cells Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice
Researchers investigated the intestinal protective effects of Wharton’s jelly derived umbilical mesenchymal stem cells on dextran sulfate sodium induced colitis in mice. [Clin Exp Pharmacol Physiol] Abstract

Cell Differentiation Mediated by Co-Culture of Human Umbilical Cord Blood Stem Cells with Murine Hepatic Cells
Purified human cord blood stem cells were co-cultivated with murine hepatic alpha mouse liver 12 cells to compare the effect on endodermal stem cell differentiation by either direct cell-cell interaction or by soluble factors in conditioned hepatic cell medium. [In Vitro Cell Dev Biol Anim] Abstract

A Dominant-Negative Isoform of IKAROS Expands Primitive Normal Human Hematopoietic Cells
Researchers used lentivirally mediated expression of a dominant-negative isoform of IKAROS to block normal IKAROS activity in primitive human cord blood cells and their progeny. [Stem Cell Rep]
Full Article | Graphical Abstract

View Data: UM729, a Novel Small Molecule for Ex Vivo Expansion of Human hSCs
 
REVIEWS
Umbilical Cord Blood-Derived Mesenchymal Stem Cells: New Therapeutic Weapons for Idiopathic Dilated Cardiomyopathy?
This article is a concise summary of cell therapy studies for idiopathic dilated cardiomyopathy, with a focus on recent advances that highlight the vascular potential exhibited by umbilical cord blood-derived mesenchymal stem cells. [Int J Cardiol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Global Controls in Stem Cells
 
INDUSTRY NEWS
Cesca Therapeutics Announces Agreement with New York Upstate Cord Blood Bank
Cesca Therapeutics Inc. announced that the company has successfully secured a contract to provide its cell storage, processing and consumables platform to Upstate Medical University’s Upstate Cord Blood Bank. [Cesca Therapeutics Inc.] Press Release

Cord Blood America, Inc. Announces Divestiture of Biocordcell Argentina, S.A.
Cord Blood America, Inc. announced that it has sold its 50.004% ownership stake in Argentina based Biocordcell Argentina, S.A. [Cord Blood America, Inc. (PR Newswire Association LLC)] Press Release

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Mesenchymal Stem Cells (a Nature Reviews Molecular Cell Biology collaboration). Request your free copy.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 2nd International Conference on Multiple Myeloma
November 7-9, 2014
Athens, Greece

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Hematopoiesis and Hematologic Malignancy (University of Michigan)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Biology (Lund University)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Molecular Mechanisms of Hematopoiesis and Blood Disorders (St. Jude Children’s Research Hospital)

Postdoctoral Positions – Models of Myelodysplastic Syndromes, Leukemia and Inherited Bone Marrow Failure (Icahn School of Medicine at Mount Sinai)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Fellow – Hematopoietic Stem Cells and Signaling Transduction (University of Pennsylvania)

Postdoctoral Positions – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Cord Tissue Processing Technician (Cord Blood Registry)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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