Volume 6.41 | Oct 23

Cord Blood News 6.41 October 23, 2014
Cord Blood News
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Erythroid Differentiation of Human Induced Pluripotent Stem Cells Is Independent of Donor Cell Type of Origin
To investigate the influence of an epigenetic memory on the ex vivo expansion of induced pluripotent stem cells into erythroid cells, scientists compared induced pluripotent stem cells from human neural stem cells and human cord blood-derived CD34+ hematopoietic stem cells and evaluated their potential for differentiation into hematopoietic progenitor and mature red blood cells. [Haematologica] Abstract | Full Article
View Data: UM729, a Novel Small Molecule for Ex Vivo Expansion of Human hSCs
PUBLICATIONS (Ranked by impact factor of the journal)
Effects of a Ceramic Biomaterial on Immune Modulatory Properties and Differentiation Potential of Human Mesenchymal Stromal Cells of Different Origin
Researchers assessed the immune modulatory properties of human mesenchymal stromal cells (MSCs) obtained from bone marrow, fat and cord blood in presence of a hydroxyapatite and tricalcium-phosphate biomaterial as a scaffold for MSC delivery. [Tissue Eng Part A] Abstract

Heterogeneous Functions of Perinatal Mesenchymal Stromal Cells Require a Preselection before Their Banking for Clinical Use
Scientists aimed to compare adult bone marrow-mesenchymal stromal cells (MSCs) with MSCs from perinatal tissues (cord blood, umbilical cord, amnion, and chorion) on their in vitro immunological and stromacytic efficiencies under different priming conditions. [Stem Cells Dev] Abstract

Transcriptomic Portrait of Human Mesenchymal Stromal/Stem Cells Isolated from Bone Marrow and Placenta
Mesenchymal stromal/stem cell (MSC) primary cultures from human bone marrow and placenta were derived and verified by their immunophenotype standard pattern and trilineage differentiation potential. Then, a broad characterization of the transcriptome of these MSCs was performed using RNA deep sequencing. [BMC Genomics] Full Article

Effect of Umbilical Cord Blood Prefreeze Variables on Postthaw Viability
Researchers investigated factors measured before freezing of the umbilical cord blood that could affect overall postthaw viability of the stem cell unit from 257 collected cord blood samples. The analysis included hematologic variables, cord blood collection characteristics, and stem cell separation and preservation factors. [Transfusion] Abstract

Umbilical Cord Wharton’s Jelly Repeated Culture System: A New Device and Method for Obtaining Abundant Mesenchymal Stem Cells for Bone Tissue Engineering
Scientists designed and evaluated an umbilical cord Wharton’s jelly repeated culture device. Using this device, mesenchymal stem cells derived from human umbilical cord Wharton’s jelly were obtained from the repeated cultures and their quantities and biological characteristics were compared. [PLoS One] Full Article

An Increase in CD3+CD4+CD25+ Regulatory T Cells after Administration of Umbilical Cord-Derived Mesenchymal Stem Cells during Sepsis
With a cecal ligation and puncture (CLP) model, the mechanisms of mesenchymal stem cell (MSC)-mediated immunoregulation during sepsis were studied by determining the changes of circulating inflammation-associated cytokine profiles and peripheral blood mononuclear cells 18 hours after CLP-induced sepsis. In vitro, bone marrow-derived MSCs and umbilical cord-derived MSCs showed a similar morphology and surface marker expression. [PLoS One] Full Article

Impact of Rabbit ATG-Containing Myeloablative Conditioning Regimens on the Outcome of Patients Undergoing Unrelated Single-Unit Cord Blood Transplantation for Hematological Malignancies
Researchers assessed the impact of antithymocyte globulin (ATG) on patient outcome in a retrospective series of 91 patients who underwent unrelated single-unit cord blood transplantation following a myeloablative conditioning regimen. [Bone Marrow Transplant] Abstract

Therapeutic Effects of Amniotic Fluid-Derived Mesenchymal Stromal Cells on Lung Injury in Rats with Emphysema
Researchers analyzed the phenotypic characteristics, differentiation potential, and karyotype of rat amniotic fluid-derived mesenchymal stromal cells, which were isolated from pregnant Sprague-Dawley rats. [Respir Res] Full Article

Umbilical Cord Blood CD34+ Stem Cells and Other Mononuclear Cell Subtypes Processed up to 96 Hours from Collection and Stored at Room Temperature Maintain a Satisfactory Functionality for Cell Therapy
The authors recently demonstrated that cord blood mononuclear cell subtypes were viable and functional until 96 hours after collection, even stored at room temperature. In the present study they analyzed the viability and functionality of the cells before and after cryopreservation. [Vox Sang] Abstract

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Plasticity of Mesenchymal Stem Cells in Immunomodulation: Pathological and Therapeutic Implications
The authors review the current findings on the immunoregulatory plasticity of mesenchymal stem cells in disease pathogenesis and therapy. [Nat Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
The Leukemia & Lymphoma Society Awards Six New Research Grants Focused on Innovative New Ideas
Six academic investigators will receive grants from The Leukemia & Lymphoma Society to support innovative ideas that that have the potential to take research in a new direction and fundamentally impact the future of blood cancer diagnosis and treatment. [The Leukemia & Lymphoma Society] Press Release

The Alliance for Regenerative Medicine (ARM) and the Alliance for Advanced Therapies (AAT) Merge to Create One Unified Voice for Next Generation Therapies in Europe and the U.S.
ARM and AAT announced the leadership of both organizations has approved a Memorandum of Understanding to merge the membership of AAT into ARM. The result of this membership merger is the creation of one, global organization operating on behalf of the advanced therapies and regenerative medicine sector (cell therapy, gene therapy and tissue engineering) in both the U.S. and Europe. [Alliance for Regenerative Medicine]
Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW ESH International Conference on New Concepts in B Cell Malignancies: From Molecular Pathogenesis to Personalized Treatment (ESH 2014)
November 14-16, 2014
Thessaloniki, Greece

Visit our events page to see a complete list of events in the cord blood community.
NEW Postdoctoral Position – NK Cell and Leukemia Research (Children’s Hospital Los Angeles)

Postdoctoral Fellow – Hematopoiesis and Hematologic Malignancy (University of Michigan)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Biology (Lund University)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Molecular Mechanisms of Hematopoiesis and Blood Disorders (St. Jude Children’s Research Hospital)

Postdoctoral Positions – Models of Myelodysplastic Syndromes, Leukemia and Inherited Bone Marrow Failure (Icahn School of Medicine at Mount Sinai)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Fellow – Hematopoietic Stem Cells and Signaling Transduction (University of Pennsylvania)

Postdoctoral Positions – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Cord Tissue Processing Technician (Cord Blood Registry)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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