Volume 6.42 | Oct 30

Cord Blood News 6.42 October 30, 2014
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Survival Rates in Pediatric Umbilical Cord Transplants May Indicate a New Standard of Care
A new standard of care for children facing acute myeloid leukemia may be clear, following a multi-year study. The research compared outcomes in children with acute leukemia and myelodysplastic syndrome who received transplants of either one or two units of partially matched cord blood. [Press release from the University of Minnesota discussing publication in The New England Journal of Medicine] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
A Hyperactive Mpl-Based Cell Growth Switch Drives Macrophage-Associated Erythropoiesis through an Erythroid-Megakaryocytic Precursor
Researchers report that amino acid substitutions in an Mpl-containing cell growth switch extending receptor stability improves the expansion capacity of human cord blood CD34+ cells in the absence of exogenous cytokines. [Blood] Abstract

Modeling De Novo Leukemogenesis from Human Cord Blood with MN1 and NUP98HOXD13
Scientists show that forced expression of MN1 in primitive human cord blood cells maintained on stromal cells in vitro induces a transient, but not serially transplantable, myeloproliferation in engrafted mice. [Blood] Abstract

Human Mesenchymal Stromal Cells Attenuate Graft-versus-Host Disease and Maintain Graft-versus-Leukemia Activity following Experimental Allogeneic Bone Marrow Transplantation
Researchers sought to define the effects and underlying mechanisms of human, marrow-derived mesenchymal stromal cells on graft-versus-host disease and graft-versus-leukemia activity. [Stem Cells] Abstract

Fungal and Viral Infections after Allogeneic Hematopoietic Transplantation from Unrelated Donors in Adults: Improving Outcomes over Time
A total of 434 consecutive unrelated transplants were retrospectively analyzed to compare overall outcomes, incidence and risk factors of severe viral and invasive fungal infections in cord blood versus BM/PB recipients. [Bone Marrow Transplant] Abstract

Expression and Significance of DLL4-Notch Signaling Pathway in the Differentiation of Human Umbilical Cord Derived Mesenchymal Stem Cells into Cardiomyocytes Induced by 5-Azacytidine
hUCMSCs were isolated and purified from the umbilical cords of normal or cesarean term deliveries under sterile conditions. Flow cytometry analysis revealed that CD13, CD29, CD44, CD90, and CD105 were highly expressed on the surface of passage-3 hUCMSCs, but negative for CD31, CD34, CD45, and HLA-DR. [Cell Biochem Biophys] Abstract

The Kinetics of Hematopoietic Niche Cytokines and Their Influence on Mobilization Efficacy and Timing in Patients with Hematological Malignancies
The bone marrow niche functions are modulated by complicated cytokines network. Scientists evaluate the levels of VCAM-1, VEGF, MMP-9 and SDF during mobilization of CD34+ cells in patients with hematological malignancies. [J Clin Apher] Abstract

Neural Differentiation of Human Umbilical Cord Matrix-Derived Mesenchymal Cells under Special Culture Conditions
For induction of neural differentiation, human umbilical cord-derived mesenchymal cells were seeded onto sterile glass slides and six various cocktails using a base medium supplemented with 10% FBS, retinoic acid, dimethyl sulfoxide, epidermal growth factor and fibroblast growth factor were used to compare their effect on neuronal, astrocyte and oligodendrocyte differentiation. [Cytotechnology] Abstract

Evaluation of Ultrasmall Superparamagnetic Iron Oxide Contrast Agent Labeling of Equine Cord Blood and Bone Marrow Mesenchymal Stromal Cells
Researchers evaluated the efficacy and effects of labeling equine umbilical cord blood- and bone marrow-derived multipotent mesenchymal stromal cells (MSCs) with an ultrasmall superparamagnetic iron oxide contrast agent and the detection of labeled MSCs by use of MRI. [Am J Vet Res] Abstract

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REVIEWS
Hematopoietic Stem Cell Transplantation for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria: Current Evidence and Recommendations
Aplastic anemia (AA) is a bone marrow failure syndrome characterized by pancytopenia and an empty bone marrow. Standard treatments for AA include immunosuppressive therapy and bone marrow transplantation. [Expert Rev Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Global Controls in Stem Cells
 
INDUSTRY NEWS
HEMACORD®, the First FDA-Licensed Stem Cell Product, Wins Prix Galien USA “Best Biotechnology Product” Award
The New York Blood Center’s Milstein National Cord Blood Program announced that HEMACORD®, the first FDA-licensed hematopoietic stem cell product, has been awarded the prestigious “Best Biotechnology Product” Award by Prix Galien USA. [New York Blood Center] Press Release

The Leukemia & Lymphoma Society Awards $15.6 Million to Help Advance Research from Lab to Clinic
The Leukemia & Lymphoma Society is awarding $15.6 million in academic grants to 26 scientists who have proposed innovative laboratory research that shows promise in leading to new treatments for blood cancer patients. [The Leukemia & Lymphoma Society] Press Release

Americord Launches Revolutionary Stem Cell Collection Process
Americord Registry announced the launch of Cord Blood 2.0™, its innovative cord blood banking system that can collect and preserve up to twice as many stem cells as traditional cord blood collections. [Americord Registry (PR Newswire Association LLC)] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 56th ASH Annual Meeting and Exposition
December 6-9, 2014
San Francisco, United States

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Molecular Mechanisms Regulating Human Hematopoietic Specification (Washington University School of Medicine)

Postdoctoral Position – NK Cell and Leukemia Research (Children’s Hospital Los Angeles)

Postdoctoral Fellow – Hematopoiesis and Hematologic Malignancy (University of Michigan)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Biology (Lund University)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Molecular Mechanisms of Hematopoiesis and Blood Disorders (St. Jude Children’s Research Hospital)

Postdoctoral Positions – Models of Myelodysplastic Syndromes, Leukemia and Inherited Bone Marrow Failure (Icahn School of Medicine at Mount Sinai)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Fellow – Hematopoietic Stem Cells and Signaling Transduction (University of Pennsylvania)

Postdoctoral Positions – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Cord Tissue Processing Technician (Cord Blood Registry)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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