Volume 6.43 | Nov 6

Cord Blood News 6.43 November 6, 2014
Cord Blood News
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Incidence, Risk Factors, and Clinical Outcome of Leukemia Relapses with Loss of the Mismatched HLA after Partially-Incompatible Hematopoietic Stem Cell Transplantation
Genomic loss of the mismatched HLA is a recently described mechanism of leukemia immune escape and relapse after allogeneic hematopoietic stem cell transplantation. Investigators evaluated its incidence, risk factors, and outcome in 233 consecutive transplants from partially HLA-mismatched related and unrelated donors. [Leukemia] Abstract
View Data: UM729, a Novel Small Molecule for Ex Vivo Expansion of Human hSCs
PUBLICATIONS (Ranked by impact factor of the journal)
Osteogenic Differentiation of Human Amniotic Epithelial Cells and Its Application in Alveolar Defect Restoration
Researchers investigated the detailed in vitro osteogenic differentiation process and in vivo bone regenerative property of human amniotic epithelial cells. [Stem Cells Transl Med] Abstract

Differentiation of Human Umbilical Cord Matrix Mesenchymal Stem Cells into Neural-Like Progenitor Cells and Maturation into an Oligodendroglial-Like Lineage
Mesenchymal stem cells were isolated from the umbilical cord matrix (Wharton’s jelly) of human umbilical cord samples. The cells were additionally subjected to an oligodendroglial-oriented step-wise differentiation protocol in order to test their neural- and oligodendroglial-like differentiation capacity. [PLoS One] Full Article

Successful Early Unmanipulated Haploidentical Transplantation with Reduced-Intensity Conditioning for Primary Graft Failure after Cord Blood Transplantation in Hematologic Malignancy Patients
Investigators analyzed 17 hematologic malignancy patients who received unmanipulated haploidentical peripheral blood and BM transplantation with reduced-intensity conditioning as a salvage therapy for primary graft failure after cord blood transplantation. [Bone Marrow Transplant] Abstract

Pre-Transplantation Risk Factors to Develop Sclerotic Chronic GvHD after Allogeneic HSCT: A Multicenter Retrospective Study from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Sclerotic chronic GvHD (cGvHD) is one of the most severe complications after allo-hematopoietic stem cell transplantation. In univariate analysis, researchers found a significantly lower number of sclerotic cGvHD form in patients transplanted from cord blood cells, in patients with one mismatched donor and in patients who had received antithymocyte globulin in the conditioning regimen. [Bone Marrow Transplant] Abstract

Comparison of Umbilical Cord Serum and Amniotic Membrane Transplantation in Acute Ocular Chemical Burns
Scientists compared the efficacy of umbilical cord serum (UCS) with amniotic membrane transplantation (AMT) in cases of acute ocular chemical burns. UCS and AMT groups showed early epithelialization as compared with the conventional medical group. [Br J Ophthalmol] Abstract

Accelerated Regeneration of Skin Injury by Co-Transplantation of Mesenchymal Stem Cells from Wharton’s Jelly of the Human Umbilical Cord Mixed with Microparticles
Investigators explored a new strategy for repairing skin wounds: co-transplantation of mesenchymal stem cells from Wharton’s jelly of the human umbilical cord and microparticles. [Cell Biochem Biophys] Abstract

Differentiation of Schwann-Like Cells from Human Umbilical Cord Blood Mesenchymal Stem Cells In Vitro
Investigators established a method of inducing directional differentiation of human umbilical cord blood (hUCB) mesenchymal stem cell (MSC) into Schwann-like cells. Cells isolated from hUCB were cultured in MesenCult complete medium, a specialized culture medium for MSCs, to expand hUCBMSCs. [Mol Med Rep] Abstract

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Autophagy and Hematopoietic Stem Cell Transplantation
The authors covers established and implicated roles of autophagy in hematopoietic stem cell transplantation, suggesting this pathway as an important therapeutic target for improving transplant outcomes. [Immunol Cell Biol] Abstract

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New Stem Cell Action Plan Promises Major Leap Forward in Alleviating Human Suffering
A coalition of Canadian stem cell advocates, researchers and charities has launched an aggressive Action Plan for Canada to lead the way in bringing up to ten breakthrough therapies to the clinic by 2025. [Canadian Stem Cell Foundation] Press Release

City of Hope Awarded $8 Million to Launch Stem Cell Therapy Clinic Focused on Fighting Incurable Disease
Identifying cures for currently incurable diseases and providing patients safe, fast, and potentially life-saving treatments is the focus of City of Hope’s new Alpha Clinic for Cell Therapy and Innovation. The clinic is funded by an $8 million, five-year grant from the California Institute for Regenerative Medicine. [City of Hope]
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NEW Cell & Gene Therapy Forum 2015
January 26-28, 2015
Washington DC, United States

NEW American Society of Gene & Cell Therapy (ASGCT) 18th Annual Meeting
May 13-16, 2015
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NEW Postdoctoral Fellow – Stem Cell Biology Gene Expression and Regulation (The University of Texas Medical School at Houston)

Postdoctoral Fellow – Molecular Mechanisms Regulating Human Hematopoietic Specification (Washington University School of Medicine)

Postdoctoral Position – NK Cell and Leukemia Research (Children’s Hospital Los Angeles)

Postdoctoral Fellow – Hematopoiesis and Hematologic Malignancy (University of Michigan)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Molecular Mechanisms of Hematopoiesis and Blood Disorders (St. Jude Children’s Research Hospital)

Postdoctoral Positions – Models of Myelodysplastic Syndromes, Leukemia and Inherited Bone Marrow Failure (Icahn School of Medicine at Mount Sinai)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Cord Tissue Processing Technician (Cord Blood Registry)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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