Volume 6.44 | Nov 13

Cord Blood News 6.44 November 13, 2014
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Autotaxin-LPA Axis Regulates hMSC Migration by Adherent Junction Disruption and Cytoskeletal Rearrangement via LPAR1/3-Dependent PKC/GSK3β/β-Catenin and PKC/Rho GTPase Pathways
The biological role of autotaxin in human umbilical cord blood-derived mesenchymal stem cells (hMSCs) migration remains to be fully elucidated. Investigators observed that hMSCs, which were stimulated with lysophosphatidic acid (LPA), accelerated wound healing, and LPA increased the migration of hMSCs into a wound site in a mouse skin wound healing model. [Stem Cells] Abstract
New Cord Banking Software Solution from STEMSOFT
 
PUBLICATIONS (Ranked by impact factor of the journal)
Calcium-Sensing Receptor-Mediated Osteogenic and Early-Stage Neurogenic Differentiation in Umbilical Cord Matrix Mesenchymal Stem Cells from a Large Animal Model
Scientists investigated, in a large animal model, the involvement of calcium-sensing receptor (CaSR) in triggering osteogenic and neurogenic differentiation of two size-sieved umbilical cord matrix mesenchymal stem cell lines, by using AMG641, a novel potent research calcimimetic acting as CaSR agonist. [PLoS One]
Full Article

Establishment of a Humanized APL Model via the Transplantation of PML-RARA-Transduced Human Common Myeloid Progenitors into Immunodeficient Mice
In order to understand the precise mechanisms involved in human acute promyelocytic leukemia (APL) leukemogenesis, investigators established a humanized in vivo APL model involving retroviral transduction of PML-RARA into CD34+ hematopoietic cells from human cord blood and transplantation of these cells into immunodeficient mice. [PLoS One] Full Article

Dendritic Cell Reconstitution Is Associated with Relapse-Free Survival and Acute GvHD Severity in Children after Allogeneic Stem Cell Transplantation
Scientists investigated the age- and sex-dependent immune reconstitution of myeloid and plasmacytoid DC in the peripheral blood of 45 children with leukemia or myelodysplastic syndrome after allo-SCT with regard to relapse, acute GvHD and relapse-free survival. [Bone Marrow Transplant] Abstract

Clinical and Biological Predictors of Outcome following Relapse of CML Post-Allo-SCT
To better define clinical and biological parameters determining postrelapse outcome, investigators studied 59 patients with CML relapsing after HLA-identical sibling allo-SCT. [Bone Marrow Transplant] Abstract

The Immunologic and Hematopoietic Profiles of Mesenchymal Stem Cells Derived from Different Sections of Human Umbilical Cord
Scientists compared immunologic and hematopoietic characteristics of mesenchymal stem cells derived from whole human umbilical cord (UC), as well as from different sections of UCs, including the amniotic membrane, Wharton’s jelly, and umbilical vessel. [Acta Biochim Biophys Sin] Abstract

Contribution of Non-Infectious Transplantation-Related Complications to the Outcome of Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia: a Single Institute Analysis
Researchers compared non-infectious transplantation-related complications post-cord blood transplantation in patients with acute myeloid leukemia with those following related bone marrow and peripheral blood transplantation and unrelated BM transplantation. [Int J Hematol] Abstract

Upregulation of Nanog and Sox-2 Genes following Ectopic Expression of Oct-4 in Amniotic Fluid Mesenchymal Stem Cells
Octamer-binding transcription factor 4 (Oct-4), an important gene regulating stem cell pluripotency, is well-known for its ability to reprogram somatic cells in vitro, either alone or in concert with other factors. Investigators assessed the effect of ectopic expression of Oct-4 in human amniotic fluid stem cells. [Biotechnol Appl Biochem] Abstract

Technical Bulletin: Assays For Cord Blood
 
REVIEWS
Umbilical Cord Blood Transplantation: Past, Present, and Future
Current excitement in the field revolves around the development of safer techniques to improve homing, engraftment, and immune reconstitution after cord blood transplantation. Here the authors review the past, present, and future of cord transplantation. [Stem Cells Transl Med] Abstract

Characteristics of Hematopoietic Stem Cells of Umbilical Cord Blood
The authors describe the differences (in phenotype, cytokine production, quantity and quality of cells) between stem cells from umbilical cord blood, bone marrow and peripheral blood. [Cytotechnology] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Don't miss ASGCT 18th Annual Meeting!
 
INDUSTRY NEWS
Case Western Reserve University to Study Pluristem’s PLX-RAD Cells in Umbilical Cord Blood Transplants for the Treatment of Blood Cancers and Genetic Diseases
Pluristem Therapeutics Inc. announced that researchers at Case Western Reserve University will conduct a preclinical study of the company’s PLacental eXpanded (PLX)-RAD cells. The study will evaluate whether PLX-RAD cells increase the success rate of human umbilical cord blood transplantation. [Pluristem Therapeutics Inc.] Press Release

Americord Funds Clinical Trial Investigating Umbilical Cord Blood Transplantation in Patients with Beta Thalassemia Major
Americord Registry announced that it has provided funding to Nanfang Hospital of Southern Medical University in Guangzhou, Guangdong, China. Funding will support research into the safety and efficacy of umbilical cord stem cell transplantations to treat beta thalassemia major. [Americord Registry (PR Newswire Association LLC)] Press Release

New wallchart from our sponsor:
Mesenchymal Stem Cells (a Nature Reviews Molecular Cell Biology collaboration).
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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW American Society of Gene & Cell Therapy (ASGCT) 18th Annual Meeting
May 13-16, 2015
New Orleans, United States

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Head of Cellular and Molecular Therapies Laboratory (NHS Blood & Transplant)

Postdoctoral Fellow – Stem Cell Biology Gene Expression and Regulation (The University of Texas Medical School at Houston)

Postdoctoral Fellow – Molecular Mechanisms Regulating Human Hematopoietic Specification (Washington University School of Medicine)

Postdoctoral Position – NK Cell and Leukemia Research (Children’s Hospital Los Angeles)

Postdoctoral Fellow – Hematopoiesis and Hematologic Malignancy (University of Michigan)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Molecular Mechanisms of Hematopoiesis and Blood Disorders (St. Jude Children’s Research Hospital)

Postdoctoral Positions – Models of Myelodysplastic Syndromes, Leukemia and Inherited Bone Marrow Failure (Icahn School of Medicine at Mount Sinai)

Cord Tissue Processing Technician (Cord Blood Registry)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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