Volume 6.49 | Dec 18

Cord Blood News 6.49 December 18, 2014
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Capillary-Like Network Formation by Human Amniotic Fluid-Derived Stem Cells within Fibrin/Poly(Ethylene Glycol) Hydrogels
To determine feasibility of amniotic fluid-derived stem cells (AFSC)-derived microvasculature, researchers compared AFSC-derived endothelial cells as a vascular cell source and AFSC as a perivascular cell source to established sources of these cell types – human umbilical vein endothelial cells and mesenchymal stem cells, respectively. [Tissue Eng Part A] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
A miRNA Signature in Human Cord Blood Stem and Progenitor Cells as Potential Biomarker of Specific Acute Myeloid Leukemia Subtypes
Investigators explored the expression of microRNAs (miRNAs) in umbilical cord blood stem and progenitor cells and compared it to unilineage granulocyte and granulo-monocyte differentiation as well as to primary blasts from patients with acute myeloid leukemia. [J Cell Physiol] Abstract

Proangiogenic Compositions of Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells
Microvesicles (MVs) derived from mesenchymal stem cells (MSCs) have been shown to promote angiogenesis. Investigators aimed to shed a light on the mechanisms by analyzing the angiogenesis-promoting compositions of MSC-MVs. [PLoS One] Full Article

Non-Enzymatic Isolation followed by Supplementation of Basic Fibroblast Growth Factor Improves Proliferation, Clonogenic Capacity and SSEA-4 Expression of Perivascular Cells from Human Umbilical Cord
Researchers report a simple non-enzymatic isolation method of perivascular cells from human umbilical cord and compare its efficiency with the conventional collagenase treatment method in terms of proliferation, immunophenotype, clonogenic capacity, and differentiation potential. [Cell Tissue Res] Abstract

Replication of Influenza Virus A in Swine Umbilical Cord Epithelial Stem-Like Cells
Scientists describe the isolation and characterization of epithelial stem-like cells from the swine umbilical cord and their susceptibility to influenza virus infection. [Virulence] Abstract

Family Directed Umbilical Cord Blood Banking for Acute Leukemia: Usage Rate in Hematopoietic Stem Cell Transplantation
Investigators assessed the usage rate of family umbilical cord blood collections directed to patients with acute leukemia and to investigate the factors influencing the usage rate. [Stem Cell Rev] Abstract

Methodological and Clinical Aspects of Alloimmunization after Granulocyte Transfusion in Patients Undergoing Allogeneic Stem Cell Transplantation
Anti-human leukocyte antigen and anti-MHC class I chain related antigens A antibody response after the administration of granulocyte transfusions in 29 patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) encompassing 109 sera was investigated by multianalyte microbead assay before and up to six months after HSCT. [Tissue Antigens] Abstract

A Comparative Study on Efficiency of Adult Fibroblasts and Amniotic Fluid-Derived Stem Cells as Donor Cells for Production of Hand-Made Cloned Buffalo (Bubalus bubalis) Embryos
The efficiency of two cell types, namely adult fibroblasts, and amniotic fluid stem cells as nuclear donor cells for somatic cell nuclear transfer by hand-made cloning in buffalo was compared. [Cytotechnology] Abstract

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REVIEWS
Advances in Umbilical Cord Blood Manipulation—From Niche to Bedside
The use of umbilical cord blood as an alternative hematopoietic cell source in lieu of bone marrow for hematopoietic reconstitution is increasingly becoming a mainstay treatment for both malignant and nonmalignant diseases, as most individuals will have at least one available, suitably HLA-matched unit of blood. [Nat Rev Clin Oncol] Abstract

Ectodermal Differentiation of Wharton’s Jelly Mesenchymal Stem Cells for Tissue Engineering and Regenerative Medicine Applications
The authors examine the differentiation potential of Wharton’s jelly mesenchymal stem cells into hair follicle, skin, neurons and sweat glands along with discussing the potential utilization of such differentiation in regenerative medicine. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
INDUSTRY NEWS
Fate Therapeutics Announces Interim Data from Ongoing Phase II PUMA Study
Fate Therapeutics, Inc. reported initial data from the first 12 subjects administered PROHEMA® in the company’s ongoing Phase II PUMA study and announced that the study’s independent Data Monitoring Committee supported continuation of the clinical trial following a second planned interim safety review. [Fate Therapeutics, Inc.] Press Release

Americord Funds Clinical Trial Examining the Use of Donor Stem Cells in Patients with Previously Treated Cancers
Americord Registry announced that it has provided funding to the Masonic Cancer Center at the University of Minnesota. Funding will support research into the possible use of donor stem cells in patients with previously treated lymphoma, myeloma, or chronic lymphocytic leukemia. [Americord Registry (PR Newswire Association LLC)] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Nordic Life Sciences Days 2015
September 9-10, 2015
Stockholm, Sweden

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Hematopoietic Gene Regulation and Leukemia (Boston Children’s Hospital)

Director of Bone Marrow Transplant (University of Utah)

Postdoctoral Positions – Stem Cells and Bioengineering (Queensland University of Technology)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

PhD Student – Department of Hematopoiesis (Sanquin)

Postdoctoral Fellow – Stem Cell Biology Gene Expression and Regulation (The University of Texas Medical School at Houston)

Postdoctoral Fellow – Molecular Mechanisms Regulating Human Hematopoietic Specification (Washington University School of Medicine)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Cord Tissue Processing Technician (Cord Blood Registry)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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