Volume 7.01 | Jan 15

Cord Blood News 7.01 January 15, 2015
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Role of Allogeneic Stem Cell Transplantation in Adult Patients with Ph-Negative Acute Lymphoblastic Leukemia
As a pediatric-inspired GRAALL protocol yielded a markedly improved outcome in adults with Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia, investigators aimed to reassess the role of allogeneic stem cell transplantation in patients treated in the GRAALL-2003/2005 trials. [Blood] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Low Intensity Lympho-Ablative Regimen followed by Autologous Hematopoietic Stem Cell Transplantation in Severe Forms of Multiple Sclerosis: A MRI-Based Clinical Study
Researchers report magnetic resonance imaging (MRI) and clinical data in a small cohort of patients treated with a low-intensity lympho-ablative regimen, followed by autologous hematopoietic stem cell transplantation. [Mult Scler] Abstract

Absolute Lymphocyte Count as Predictor of Overall Survival for Patients with Multiple Myeloma Treated with Single Autologous Stem Cell Transplant
To assess whether absolute lymphocyte count (ALC) recovery has prognostic significance in patients with MM undergoing single autologous stem cell transplant (ASCT), researchers conducted a retrospective analysis of ALC at different time-points in patients with MM. [Leuk Lymphoma] Abstract

High-Dose Chemotherapy with Full BEAM followed by Autologous Stem Cell Transplantation Is an Effective Treatment for Elderly Patients with Poor-Prognosis Lymphoma
Scientists present a retrospective analysis of 73 consecutive patients aged over 65 years treated for aggressive or relapsed lymphoma by high-dose chemotherapy with BEAM at full dosage followed by autologous stem cell transplantation. [Leuk Lymphoma] Abstract

Haploidentical Stem Cell Transplantation Augmented by CD45RA Negative Lymphocytes Provides Rapid Engraftment and Excellent Tolerability
Eight children with relapsed or refractory solid tumors were transplanted following myeloablative conditioning. Each patient received two cell products, one created by CD3 depletion and the other through CD45RA depletion. [Pediatr Blood Cancer] Abstract

Prolonged Clinical Remissions in Patients with Relapsed or Refractory Follicular Lymphoma Treated with Autologous Stem Cell Transplantation Incorporating Rituximab
Three sequential Phase II trials were conducted with different immunotherapy approaches to enhance the outcome of autologous transplant (high-dose therapy and autologous stem cell transplantation) for recurrent follicular lymphoma. [Ann Hematol] Abstract

The Effect of Extended Passaging on the Phenotype and Osteogenic Potential of Human Umbilical Cord Mesenchymal Stem Cells
Investigators aimed to assess morphology, viability, mesenchymal stem cell (MSC) marker expression, and osteogenic activity of human umbilical cord MSCs after extended passaging. [Mol Cell Biochem] Abstract

Extracellular Regulated Protein Kinases 1/2 Phosphorylation Is Required for Hepatic Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells
Scientists investigated the signals involved in the hepatic differentiation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs). hUCMSCs were treated with mouse fetal liver-conditioned medium to induce hepatic differentiation. [Exp Biol Med] Abstract

Effect of Genetic Polymorphism of Cyp3A5 and Cyp2C19, and Concomitant Use of Voriconazole on Blood Tacrolimus Concentration in Patients Receiving Hematopoietic Stem Cell Transplantation
This study is a single-institute, prospective study including 21 adult patients who underwent hematopoietic stem cell transplantation and received 24 hour continuous intravenous administration of tacrolimus at Mie University Hospital. [Ther Drug Monit] Abstract

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REVIEWS
Novel Strategies to Prevent Relapse after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes
The most recent evidence suggests that strategies using natural killer cell therapy and targeted immune therapies after hematopoietic stem cell transplantation (HSCT) may change the current landscape of HSCT for acute myeloid leukemia and myelodysplastic syndromes. [Curr Opin Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
INDUSTRY NEWS
Cord Blood Registry and Cellular Dynamics International Announce Collaboration to Reprogram Newborn Stem Cells into Induced Pluripotent Stem Cells
Cord Blood Registry® and Cellular Dynamics International announced that they have entered into a research collaboration to reprogram newborn stem cells from both umbilical cord blood and umbilical cord tissue collected, processed and cryopreserved under CBR’s protocols into induced pluripotent stem cells using CDI’s proprietary methods. [Cord Blood Registry (PR Association LLC)] Press Release

First Patient Successfully Transplanted with Cryopreserved (Frozen) NiCord® in Gamida Cell’s Ongoing Phase I/II Clinical Trial for Blood Cancers
Gamida Cell announced that the first person has been successfully transplanted with cryopreserved NiCord® in the company’s ongoing Phase I/II clinical study for blood cancer patients. [Gamida Cell]
Press Release

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POLICY NEWS
Nature Owner Merges with Publishing Giant
Macmillan Science and Education, the London-based publisher of Nature and Scientific American, will merge with Berlin-based Springer Science+Business Media, one of the world’s largest science publishers. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW CIRM 2.0 Free Webinar – Changing the Way We Work
January 21, 2015 12:00 PM EST
Online

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Principal Investigator – Stem Cell Biology, Hematopoiesis and Hematology (Guangzhou Women and Children’s Medical Center)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Postdoctoral Position – Hematopoietic Gene Regulation and Leukemia (Boston Children’s Hospital)

Director of Bone Marrow Transplant (University of Utah)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

Postdoctoral Fellow – Stem Cell Biology Gene Expression and Regulation (The University of Texas Medical School at Houston)

Cord Tissue Processing Technician (Cord Blood Registry)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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