Volume 7.03 | Jan 29

Cord Blood News 7.03 January 29, 2015
Cord Blood News
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Molecular and Phenotypic Characterization of Human Amniotic Fluid-Derived Cells. a Morphological and Proteomic Approach
Two predominant cell types, i.e. epithelial-like (E-like) and fibroblast-like (F-like), have been detected in the amniotic fluid (AF). Investigators examined the amniotic fluid from 12 donors and observed the prevalence of the E-like phenotype in five, whereas the F-like morphology was predominant in seven samples. [Stem Cells Dev] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Human Placenta-Derived Multipotent Cells (hPDMCs) Modulate Cardiac Injury: From Bench to Small & Large Animal Myocardial Ischemia Studies
The authors report that hPDMCs can modulate cardiac injury in small and large animal models of myocardial ischemia, and elucidate the mechanisms involved. They found that hPDMCs can undergo in vitro cardiomyogenic differentiation when co-cultured with mouse neonatal cardiomyocytes. [Cell Transplant]
Full Article

Mycophenolate Based GvHD Prophylaxis Is Not Inferior to Methotrexate in Myeloablative Related Donor Stem Cell Transplantation
Investigators retrospectively reviewed 242 patients who received related donor myeloablative peripheral blood hematopoietic cell transplantation. They compared patients who received mycophenolate/cyclosporine (CSA), to historical controls who received methotrexate/CSA. [Am J Hematol] Abstract

Cord Blood Collection and Banking from a Population with Highly Diverse Geographic Origins Increase HLA Diversity in the Registry and Do Not Lower the Proportion of Validated Cord Blood Units: Experience of the Marseille Cord Blood Bank
Scientists compared biological characteristics of 106 cord blood units (CBU) disqualified for total nucleated cell count (dCBU) and 136 qualified CBU in relation to registry enrichment and haplotype origin A high proportion of both dCBU and CBU had at least one non-European haplotype and enrich CB and unrelated donor registries to a higher extent than those with two European haplotypes. [Bone Marrow Transplant] Abstract

Efficiency of Allogeneic Hematopoietic SCT from HLA Fully-Matched Non-Sibling Relatives: A New Prospect of Exploiting Extended Family Search
Researchers retrospectively studied the hematopoietic SCT outcome in patients with fully-matched non-sibling donors. In 83 patients, full chimerism and in 17 patients, mixed chimerism was achieved. Acute GvHD grade II-IV appeared in 36 patients. [Bone Marrow Transplant] Abstract

Absolute Lymphocyte Count Recovery after Allogeneic Hematopoietic Stem Cell Transplantation Predicts Clinical Outcome
To determine the impact of absolute lymphocyte count recovery on clinical outcomes investigators conducted a retrospective study of 1,109 adult patients who underwent a first allogeneic hematopoietic stem cell transplantation, excluding patients who died or relapsed before day 30. [Biol Blood Marrow Transplant] Abstract

Hematopoietic Recovery of Acute Radiation Syndrome by Human Superoxide Dismutase-Expressing Umbilical Cord Mesenchymal Stromal Cells
Investigators examined an alternative therapeutic approach to acute radiation syndrome with the use of human extracellular superoxide dismutase-modified umbilical cord mesenchymal stromal cells. [Cytotherapy] Abstract

Allogeneic Hematopoietic Stem Cell Transplantation for Adult Patients with Mixed Phenotype Acute Leukemia: Results of a Matched-Pair Analysis
Researchers retrospectively assessed the efficacy of allogeneic stem cell transplantation for mixed phenotype acute leukemia (MPAL). Eighteen patients with MPAL were identified from the transplant outcome database of KSGCT. [Eur J Haematol] Abstract

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Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy
The human umbilical cord is a promising source of mesenchymal stem cells. The authors critically evaluate their therapeutic value, challenges, and future directions for their clinical applications. [Cell Transplant] Full Article

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Derma Sciences Expands Access of Its Amniotic Tissue Product Line with New Premier, Inc. Agreement
Derma Sciences, Inc. announced that AMNIOEXCEL® and AMNIOMATRIX®, amniotic allografts derived from placental tissues, have been added to the Premier, Inc. Regenerative Skin Grafting contract portfolio. [Derma Sciences, Inc.] Press Release

Actinium Submits Pre-IND Meeting Request to the U.S. FDA for Its Iomab-B Drug Candidate
Actinium Pharmaceuticals, Inc. announced that it has submitted a request for a pre-IND (Investigational New Drug) meeting to the U.S. Food and Drug Administration (FDA) for the company’s Iomab-B drug candidate currently undergoing final preparations to start the pivotal Phase III trial in mid-2015. [Actinium Pharmaceuticals, Inc.] Press Release

From our sponsor: Free human hematopoietic progenitors wallchart. Request your copy.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW World Conference on Regenerative Medicine
October 21-23, 2015
Leipzig, Germany

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NEW Postdoctoral Fellow – Hematology and Oncology (Guangzhou Women and Children’s Medical Center)

NEW Research Associate – Generating Mature Blood Cells from Induced Pluripotent Stem Cells (University of Cambridge)

NEW Postdoctoral Fellow – Targeted Gene Editing in Hematopoietic Stem Cells (University Medical Center Freiburg)

Director (California Institute for Regenerative Medicine)

Principal Investigator – Stem Cell Biology, Hematopoiesis and Hematology (Guangzhou Women and Children’s Medical Center)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Postdoctoral Position – Hematopoietic Gene Regulation and Leukemia (Boston Children’s Hospital)

Cord Tissue Processing Technician (Cord Blood Registry)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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