Volume 7.04 | Feb 5

Cord Blood News 7.04 February 5, 2015
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Rescue of the Mucocutaneous Manifestations by Human Cord Blood Derived Non-Hematopoietic Stem Cells in a Mouse Model of Recessive Dystrophic Epidermolysis Bullosa
The authors previously demonstrated that human umbilical cord blood derived unrestricted somatic stem cells (USSCs) express type VII collagen (C7) and facilitate wound healing in a murine wounding model. They now investigate the therapeutic functions of USSCs in the C7 null C57BL6/J mice, a murine model of recessive dystrophic epidermolysis bullosa. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Rat-Derived Amniotic Epithelial Cells Differentiate into Mature Hepatocytes In Vivo with No Evidence of Cell Fusion
Four-weeks old GFP+/DPP-IV rats were treated with retrorsine and then transplanted with undifferentiated amniotic epithelial cells isolated from the placenta of DPP-IV+ pregnant rats at 16-19 days of gestational age. [Stem Cells Dev] Abstract

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury
Scientists demonstrate remarkable combined efficacy of human umbilical cord blood cell therapy and granulocyte-colony stimulating factor (G-CSF) treatment in traumatic brain injury (TBI) models, providing essential evidence for the translation of this approach to treat TBI. [Cell Transplant] Full Article

Exploring the Heterogeneity of the Hematopoietic Stem and Progenitor Cell Pool in Cord Blood: Simultaneous Staining for Side Population, Aldehyde Dehydrogenase Activity, and CD34 Expression
Investigators developed a protocol for simultaneous determination of CD34+, side population, and aldehyde dehydrogenase+ populations in relation to immature white blood cells in cord blood. [Transfusion] Abstract

Cell Fusion between Gastric Epithelial Cells and Mesenchymal Stem Cells Results in Epithelial-to-Mesenchymal Transition and Malignant Transformation
Researchers investigated the effect of cell fusion between mesenchymal stem cells and the gastric epithelial cells in tumorigenesis. Cell fusion between cord blood mesenchymal stem cells and human gastric epithelial cells was performed in vitro. [BMC Cancer] Full Article

Application of Affinity Aqueous Two-Phase Systems for the Fractionation of CD133+ Stem Cells from Human Umbilical Cord Blood
The authors implemented traditional and novel immunoaffinity aqueous two-phase systems to prove the viability of cluster of differentiation 133 (CD133+) stem cells from human umbilical cord blood. [J Mol Recognit] Abstract

Wharton’s Jelly Transplantation Improves Neurologic Function in a Rat Model of Traumatic Brain Injury
Scientists tested the efficacy of Wharton’s jelly (WJ) tissue transplantation in a weight-drop model of traumatic brain injury (TBI) in rats. WJ tissue was cultured and transplanted into the injury site 24 hours after TBI. [Cell Mol Neurobiol] Abstract

Double Labeling of Human Umbilical Cord Mesenchymal Stem Cells with Gd-DTPA and PKH26 and the Influence on Biological Characteristics of hUCMSCs
Researchers aimed to determine whether double labeling of human umbilical cord mesenchymal stem cells (hUCMSCs) with gadolinium-diethylene triamine penta-acetic acid (Gd-DTPA) and PKH26 influences their biological characteristics. [Int J Exp Pathol] Abstract

Transplantation of Human Umbilical Cord-Derived Mesenchymal Stems Cells for the Treatment of Becker Muscular Dystrophy in Affected Pedigree Members
The utility of multipotent human umbilical cord-derived mesenchymal stem cells in the treatment of Becker muscular dystrophy (BMD), a genetic disease where muscle tissue fails to regenerate, was examined in members from a pedigree affected by BMD. [Int J Mol Med] Abstract

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REVIEWS
Adoptive Immunotherapy with the Use of Regulatory T Cells and Virus-Specific T Cells Derived from Cord Blood
The authors describe how current strategies that use cord blood-derived regulatory T cells and virus-specific T cells have been developed to improve outcomes for cord blood transplant recipients. [Cytotherapy] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
INDUSTRY NEWS
Cord Blood Registry Announces Formation of Scientific & Medical Advisory Board
Cord Blood Registry® (CBR®) announced the establishment of a Scientific and Medical Advisory Board (SMAB). Composed of internationally renowned stem cell experts, the SMAB will provide input and guidance to help advance CBR’s mission to expand the scope of newborn stem cell therapies that may be available to patients and their families. [Cord Blood Registry®] Press Release

Cord Blood Registry and China Cord Blood Corporation Enter into Strategic Collaboration
Cord Blood Registry® and China Cord Blood Corporation China’s first and largest umbilical cord blood bank, entered into a memorandum of understanding regarding their strategic collaboration in China and the United States. [Cord Blood Registry®] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW BIT’s 8th Annual World Congress of Regenerative Medicine & Stem Cell (RMSC) 2015
March 19-21, 2015
Busan, South Korea

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Senior Process Development Engineer (Sangamo BioSciences, Inc.)

NEW Director – Vector Production (Sangamo BioSciences, Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Hematology and Oncology (Guangzhou Women and Children’s Medical Center)

Research Associate – Generating Mature Blood Cells from Induced Pluripotent Stem Cells (University of Cambridge)

Postdoctoral Fellow – Targeted Gene Editing in Hematopoietic Stem Cells (University Medical Center Freiburg)

Principal Investigator – Stem Cell Biology, Hematopoiesis and Hematology (Guangzhou Women and Children’s Medical Center)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Postdoctoral Position – Hematopoietic Gene Regulation and Leukemia (Boston Children’s Hospital)

Cord Tissue Processing Technician (Cord Blood Registry)


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