Volume 7.06 | Feb 19

Cord Blood News 7.06 February 19, 2015
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Restricted Dendritic Cell and Monocyte Progenitors in Human Cord Blood and Bone Marrow
Researchers report a culture system that supports development of CD34+ hematopoietic stem cell progenitors into the three major human dendritic cell subsets, monocytes, granulocytes, and NK and B cells. [J Exp Med] Abstract
Learn More: UM729, a Novel Small Molecule for Ex Vivo Expansion of Human HSCs
 
PUBLICATIONS (Ranked by impact factor of the journal)
Immune Thrombocytopenia: Antiplatelet Autoantibodies Inhibit Proplatelet Formation by Megakaryocytes and Impair Platelet Production In Vitro
Investigators examined the effects of serum and IgG from 19 immune thrombocytopenia patients using day 8 or 9 megakaryocytes, derived from cord blood hematopoietic stem cells. [Haematologica] Abstract | Full Article

Transplanted Umbilical Cord Mesenchymal Stem Cells Modify the In Vivo Microenvironment Enhancing Angiogenesis and Leading to Bone Regeneration
Scientists prepared clinical-grade umbilical cord (UC) mesenchymal stem cells (MSC) from Wharton’s jelly and they investigated if UC-MSC could be used as substitutes for bone marrow MSC in muscoloskeletal regeneration as a more readily available and functional source of MSCs. [Stem Cells Dev] Abstract

Expression of a Surface Antigen (MA6) by Peripheral Blood CD34+ Cells Is Correlated with Improved Platelet Engraftment and May Explain Delayed Platelet Engraftment following Cord Blood Transplantation
Researchers identified a subpopulation of CD34+ cells that co-express a surface antigen — “MA6”, which is more positively correlated with platelet engraftment in a clinical setting than CD34+ alone. [Stem Cells Dev] Abstract

Human Placenta-Derived Adherent Cells Improve Cardiac Performance in Mice with Chronic Heart Failure
PDA-001, an intravenous formulation of placenta-derived adherent cells, is in clinical development for the treatment of autoimmune and inflammatory diseases. Scientists tested the therapeutic effects of PDA-001 in mice with chronic heart failure. [Stem Cells Transl Med] Abstract | Full Article

Developing a Co-Culture System for Effective Megakaryo/Thrombopoiesis from Umbilical Cord Blood Hematopoietic Stem/Progenitor Cells
Investigators exploited a two-stage culture protocol to study the effect of different parameters on the megakaryo/thrombopoiesis ex vivo. In the expansion stage, human umbilical cord blood-derived CD34+-enriched cells were expanded in co-culture with human bone marrow mesenchymal stromal cells. [Cytotherapy] Abstract

Bone Formation by Human Umbilical Cord Perivascular Cells
Scientists investigated the possibility of employing human umbilical perivascular cells within the context of finding an alternative source of mesenchymal stromal cells for bone tissue engineering. [J Biomed Mater Res A] Abstract

Comparative Quantification of the Surfaceome of Human Multipotent Mesenchymal Progenitor Cells
Investigators employed subcellular fractionation with quantitative discovery proteomics to define the cell-surface interface proteome of human bone marrow mesenchymal stromal/stem cells and human umbilical cord perivascular cells. [Stem Cell Reports] Full Article

Free Sample: TeSR™2 Defined, Feeder-Free and Xeno-Free Human ES and iPS Cell Medium
 
REVIEWS
Mobilized Peripheral Blood Grafts Include More than Hematopoietic Stem Cells: The Immunological Perspective
With the increasing use of plerixafor and the inclusion of poor mobilizers in autologous transplant procedures, new parameters other than CD34+ stem cell dose are emerging; plerixafor seems to mobilize more primitive CD34+/CD38 stem cells compared with G-CSF, but their correlation with stable hematopoietic engraftment is still obscure. [Bone Marrow Transplant] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
INDUSTRY NEWS
Kaul Foundation Donates $7 Million for UAB Personalized Medicine Institute
The Hugh Kaul Foundation has donated $7 million to the University of Alabama at Birmingham (UAB) to establish the Hugh Kaul Personalized Medicine Institute at UAB. [University of Alabama at Birmingham]
Press Release

TiGenix and Lonza Sign Agreement for the Manufacture of Stem Cell-Based Treatment
Lonza and TiGenix announced an agreement for the supply of TiGenix’s expanded adipose-derived stem cell product, Cx601. Under the agreement, Lonza will manufacture material for the Phase III trial of Cx601 in the US at Lonza’s cell therapy production facility in Walkersville, Maryland. [Lonza Group Ltd.] Press Release

New wallchart from our sponsor:
Mesenchymal Stem Cells (a Nature Reviews Molecular Cell Biology collaboration).
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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW South Central Association of Blood Banks (SCABB) Mid-Atlantic Symposium: In Search of the Safe & Effective Transfusion
April 10, 2015
Annapolis, United States

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW PhD Studentship – Stem Cells and Tissue Engineering (Queensland University of Technology)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Scientist – Hematopoietic Stem Cell Transplantation (Indiana University)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

Postdoctoral Fellow – Hematology and Oncology (Guangzhou Women and Children’s Medical Center)

Research Associate – Generating Mature Blood Cells from Induced Pluripotent Stem Cells (University of Cambridge)

Principal Investigator – Stem Cell Biology, Hematopoiesis and Hematology (Guangzhou Women and Children’s Medical Center)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Cord Tissue Processing Technician (Cord Blood Registry)


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