Volume 7.07 | Feb 26

Cord Blood News 7.07 February 26, 2015
Cord Blood News
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Lipase Catalyzed Dissipative Self-Assembly of a Thixotropic Peptide Bolaamphiphile Hydrogel for Human Umbilical Cord Stem Cells Proliferation
The thixotropic dynamic combinatorial library hydrogel matrix used for 3D cell culture experiments for different periods of time significantly supported the cells survival and proliferation of human umbilical cord mesenchymal stem cells. [Biomacromolecules] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Bone Tissue Engineering via Human Induced Pluripotent, Umbilical Cord and Bone Marrow Mesenchymal Stem Cells in Rat Cranium
The authors investigated human induced pluripotent stem cells, human umbilical cord mesenchymal stem cells (MSCs), and human bone marrow MSCs for bone tissue engineering, and compared their bone regeneration via seeding on biofunctionalized macroporous calcium phosphate cement in rat cranial defects. [Acta Biomater] Abstract

Increased Expression of HIF2α during Iron Deficiency-Associated Megakaryocytic Differentiation
Researchers evaluated the megakaryocyte differentiation under iron deficiency in an in vitro model and investigated potential genes involved in this process. HEL, CMK, and cord blood-derived hematopoietic stem cells were cultured under iron deficiency. [J Thromb Haemost] Abstract

Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2-Producing Transgenic NOG Mouse
Scientists generated a severe immunodeficient NOD/Shi-scid-IL-2Rγnull (NOG) mouse substrain expressing the transgenic human IL-2 gene (NOG-IL-2 Tg). Upon transfer of human cord blood-derived hematopoietic stem cells, CD3CD56highCD16+/- cells developed unexpectedly, predominantly in the NOG-IL-2 Tg. [J Immunol] Abstract

Extensive Characterization of Platelet Gel Releasate from Cord Blood in Regenerative Medicine
Using a wide proteomic array and splitting the two components of the releasate, i.e. platelets and plasma, researchers have been able to study their growth factor content. They discovered high levels of hormones and molecules able to support tissue growth in the cord blood platelet gel releasate. [Cell Transplant] Full Article

The Notch Signaling Regulates CD105 Expression, Osteogenic Differentiation and Immunomodulation of Human Umbilical Cord Mesenchymal Stem Cells
To investigate the involvement of Notch signaling as well as other potential signaling pathway(s) in regulating multi-lineage differentiation and immunomodulatory functions of mesenchymal stem cells, scientists treated human umbilical cord-derived mesenchymal stem cells with γ-secretase inhibitor I, which inhibits both Notch signaling and ubiquitin-proteasome activities. [PLoS One] Full Article

Cord Blood Transplantation for Multiple Myeloma: Study from the Multiple Myeloma Working Group of the Japan Society for Hematopoietic Cell Transplantation
Scientists evaluated the feasibility of cord blood transplantation (CBT) for patients with multiple myeloma. Eighty-six patients with multiple myeloma who underwent a first CBT between 2001 and 2011 were included in this retrospective study. [Biol Blood Marrow Transplant] Abstract

The Role of Toll-Like Receptor 3 and 4 in Regulating the Function of Mesenchymal Stem Cells Isolated from Umbilical Cord
The authors demonstrate that the activation of two toll-like receptors (TLRs), namely TLR3 and TLR4, in human umbilical cord-derived mesenchymal stem cells induces the expression of inflammatory markers. [Int J Mol Med] Abstract

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Transcription Factor-Mediated Reprogramming toward Hematopoietic Stem Cells
The authors integrate the recently reported strategies to directly convert a variety of starting cell types toward hematopoietic stem cells (HSCs) in the context of hematopoietic transcriptional regulation and discuss how these findings could be further developed toward the ultimate generation of therapeutic human HSCs. [EMBO J] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
ESPERITE (Euronext ESP) Pioneers First Treatment Worldwide of Cerebral Palsy Using Two Types of Stem Cells
CryoSave leads and sponsors a multicenter clinical trial following GCP-ICH standards, for investigation of new treatment of cerebral palsy using dual infusion of two types of stem cells derived from umbilical cord blood and cord tissue processed by CryoSave [ESPERITE NV] Press Release

MD Anderson Joins CATCH® Global Foundation to Boost Child Health, Prevent Cancer in Later Years
The University of Texas System Board of Regents approved the agreement that makes MD Anderson a founding partner in the foundation. Coordinated Approach to Child Health (CATCH®) is a program developed and disseminated by The University of Texas Health Science Center at Houston School of Public Health. [The University of Texas MD Anderson Cancer Center] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Keystone Symposium – Co-Infection: A Global Challenge for Disease Control
March 15-20, 2015
Ouro Preto, Brazil

Visit our events page to see a complete list of events in the cord blood community.
NEW Postdoctoral Fellows – Leukemia Research and Stem Cell Biology (Josep Carreras Leukemia Research Institute)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

PhD Studentship – Stem Cells and Tissue Engineering (Queensland University of Technology)

Postdoctoral Scientist – Hematopoietic Stem Cell Transplantation (Indiana University)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

Postdoctoral Fellow – Hematology and Oncology (Guangzhou Women and Children’s Medical Center)

Research Associate – Generating Mature Blood Cells from Induced Pluripotent Stem Cells (University of Cambridge)

Principal Investigator – Stem Cell Biology, Hematopoiesis and Hematology (Guangzhou Women and Children’s Medical Center)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Cord Tissue Processing Technician (Cord Blood Registry)

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