Enforced Fucosylation of Cord Blood Hematopoietic Cells Accelerates Neutrophil and Platelet Engraftment after Transplantation
Delayed engraftment is a major limitation of cord blood (CB) transplantation, due in part to a defect in the CB cells’ ability to home to the bone marrow. Because this defect appears related to low levels of fucosylation of cell surface molecules that are responsible for binding to P- and E-selectins constitutively expressed by the marrow microvasculature, and thus for marrow homing, the authors conducted a first-in-humans clinical trial to correct this deficiency. [Blood] Abstract
Effects of Hypoxia on Proliferation of Human Cord Blood-Derived Mesenchymal Stem Cells
Investigators examined the influence of hypoxia on proliferation of human umbilical cord blood-derived mesenchymal stem cells. The mononuclear cells were separated by density gradient centrifugation from human umbilical cord blood and then, respectively, cultured under hypoxia or normoxia. [Cytotechnology] Abstract
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