Volume 7.11 | Mar 26

Cord Blood News 7.11 March 26, 2015
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Stem Cells from Human Amniotic Fluid Exert Immunoregulatory Function via Secreted Indoleamine 2,3-Dioxygenase1
On coculture with human peripheral blood mononuclear cells, interferon-γ-treated fast human amniotic fluid stem cells caused significantly decreased T-cell proliferation and increased frequency in CD4+ CD25+ FOXP3+ regulatory T cells. [J Cell Mol Med] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
The Effects of Secretion Factors from Umbilical Cord Derived Mesenchymal Stem Cells on Osteogenic Differentiation of Mesenchymal Stem Cells
Researchers investigated the effects of secretion factors of human umbilical cord derived mesenchymal stem cells (MSCs) on osteogenesis of human bone marrow derived MSCs. [PLoS One] Full Article

Microvesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Tubular Epithelial Cell Dedifferentiation and Growth via Hepatocyte Growth Factor Induction
In a rat model of unilateral acute kidney injury, the administration of mesenchymal stem cell-derived microvesicles promoted kidney recovery. One of the mechanisms of action is the acceleration of tubular cell dedifferentiation and growth. [PLoS One] Full Article

Impact of Length of Cryopreservation and Origin of Cord Blood Units on Hematologic Recovery following Cord Blood Transplantation
To determine whether long-term cryopreservation and international shipment of cord blood units (CBUs) affect the quality of the units and outcome after transplantation, scientists retrospectively analyzed the quality of 95 CBUs and the hematologic recovery of 127 patients with hematological malignancy following single-unit cord blood transplantation. [Bone Marrow Transplant] Abstract

Human Allogeneic AB0/Rh-Identical Umbilical Cord Blood Cells in the Treatment of Juvenile Patients with Cerebral Palsy
During a post-registration clinical investigation, the safety and efficacy of intravenous infusion of allogeneic human leukocyte antigen-unmatched umbilical cord blood cells were studied in 80 pediatric patients with cerebral palsy and associated neurological complications. [Cytotherapy] Abstract

Human Umbilical Cord Blood Cells Ameliorate Motor Deficits in Rabbits in a Cerebral Palsy Model
Scientists tested human umbilical cord blood cell therapy in a validated rabbit model of cerebral palsy after acute changes secondary to hypoxic-ischemic injury had subsided. [Dev Neurosci] Abstract

Enhanced Endothelial Progenitor Cell Mobilization and Function through Direct Manipulation of Hypoxia Inducible Factor-1α
Researchers investigated the effects of directly manipulating hypoxia-inducible factor-1α on human endothelial progenitor cells (EPCs) in vitro. EPCs were isolated from human umbilical cord blood. [Cell Biochem Funct] Abstract

Therapeutic Potential of Human Umbilical Cord Blood Mesenchymal Stem Cells on Erectile Function in Rats with Cavernous Nerve Injury
Investigators evaluated the therapeutic potential of human umbilical cord blood mesenchymal stem cells on promoting erectile function in a rat model of bilateral cavernous nerve crush injury. [Biotechnol Lett] Abstract

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REVIEWS
Umbilical Cord Blood-Derived Cellular Products for Cancer Immunotherapy
The authors focus on cellular immunotherapies derived from cord blood (CB). Expansion techniques, ongoing clinical trials and future directions for this new dimension of CB application are also discussed. [Cytotherapy] Abstract

Therapeutic Potential of Umbilical Cord Blood Cells for Type 1 Diabetes Mellitus
The authors revisit the role of autologous umbilical cord blood or immune cells from cord blood based applications for the treatment of type 1 diabetes mellitus. [J Diabetes] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

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INDUSTRY NEWS
City of Hope Launches Stem Cell Therapy Clinic to Fight Incurable Disease in New Ways
The City of Hope officially opened the Alpha Clinic for Cell Therapy and Innovation for patients battling cancer and other life-threatening diseases. The Alpha Clinic is funded by an $8 million, five-year grant from the California Institute for Regenerative Medicine that will be supplemented by matching funds from City of Hope. [City of Hope] Press Release

Researchers Aim to Broaden Understanding of How Toxins Affect the Body
University of Wisconsin-Madison researchers received $6 million from the U.S. Environmental Protection Agency to develop models and screening tools that will rapidly advance knowledge of the health effects of an ever-growing assortment of environmental toxins. Awarded through the EPA Science to Achieve Results program, the grant will create the Human Models for Analysis of Pathways Center at UW-Madison. [University of Wisconsin-Madison] Press Release

Accellta Grants Exclusive Rights for Micro-Carrier Free Stem Cells Suspension Culture to STEMCELL Technologies
The stem cell company Accellta announced that it has granted exclusive worldwide rights to STEMCELL Technologies Inc. for manufacturing and distribution of medium for culturing pluripotent stem cells in suspension under feeder-free, non-adherent conditions. [Accellta Ltd.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW SelectBio Stem Cells in Drug Discovery
June 2-3, 2015
Cambridge, United Kingdom

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Hematopoietic Stem Cell Biology (University of Leuven)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Hematopoietic and Leukemic Stem Cells (Shanghai Jiao-Tong University School of Medicine)

Research Scientist – Cell Signaling in Normal and Leukemic Hematopoietic Stem and Progenitor Cells (Indiana University)

Manufacturing Manager – Cell Therapy (Opexa Therapeutics)

Postdoctoral Fellows – Leukemia Research and Stem Cell Biology (Josep Carreras Leukemia Research Institute)

PhD Studentship – Stem Cells and Tissue Engineering (Queensland University of Technology)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Cord Tissue Processing Technician (Cord Blood Registry)


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