Volume 7.12 | Apr 2

Cord Blood News 7.12 April 2, 2015
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Novel Pathway for Hypoxia-Induced Proliferation and Migration in Human Mesenchymal Stem Cells: Involvement of HIF-1α, FASN, and mTORC1
Investigators identified hypoxia-inducible lipid metabolic enzymes that can regulate umbilical cord blood (UCB)-derived human mesenchymal stem cell (hMSC) proliferation and migration and to demonstrated the signaling pathway that controls functional change in UCB-hMSCs. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
CD133 Allows Elaborated Discrimination and Quantification of Hematopoietic Progenitor Subsets in Human Hematopoietic Stem Cell Transplants
To qualify the assessment of CD133 for routine quality control of adult hematopoietic stem cell (HSC) sources, researchers analyzed the developmental potentials of CD133+ and CD133low subpopulations in bone marrow and peripheral blood stem cells. Similar to umbilical cord blood, CD133 expression objectively discriminated functionally distinct subpopulations in adult HSC sources. [Br J Haematol] Abstract

Computational Modeling of the Expansion of Human Cord Blood CD133+ Hematopoietic Stem/Progenitor Cells with Different Cytokine Combinations
Scientists developed a computational model based on cellular signaling interactions that predict the influence of a cytokine on the survival, duplication and differentiation of the CD133+ hematopoietic stem and progenitor cell subset from human umbilical cord blood. [Bioinformatics] Abstract

Paracrine Effects of Mesenchymal Stem Cells Induce Senescence and Differentiation of Glioblastoma Stem-Like Cells
Scientists found that conditioned media from bone marrow and umbilical cord derived mesenchymal stem cells mediated cell cycle arrest of glioblastoma multiforme stem-like cells by downregulating cyclin D1. [Cell Transplant] Full Article

Wnt3a Protein Reduces Growth Factor-Driven Expansion of Human Hematopoietic Stem and Progenitor Cells in Serum-Free Cultures
Researchers demonstrated that exogenous Wnt3a protein suppresses rather than promotes the expansion of umbilical cord blood-derived CD34+ cells in serum free expansion cultures. [PLoS One] Full Article

Hypothermia Augments Neuroprotective Activity of Mesenchymal Stem Cells for Neonatal Hypoxic-Ischemic Encephalopathy
Scientists hypothesized that combined treatment with hypothermia and transplantation of human umbilical cord blood-derived mesenchymal stem cells would synergistically attenuate severe hypoxic-ischemic encephalopathy compared to stand-alone therapy. [PLoS One] Full Article

Comparative Proteomic Analysis of Two Distinct Stem-Cell Populations from Human Amniotic Fluid
Investigators characterized two distinct types of stem cells isolated from residual amniotic fluid material derived from prenatal diagnostic amniocentesis. [Mol Biosyst] Abstract

Investigating the Effect of Hypoxic Culture on the Endothelial Differentiation of Human Amniotic Fluid-Derived Stem Cells
Scientists investigated the ability of amniotic fluid-derived stem cells to differentiate down an endothelial lineage with the aim of producing an endothelial-like cell suitable for use in pre-vascularization. [J Anat] Abstract

Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Germ-Like Cells in Mouse Seminiferous Tubules
The authors’ previous study demonstrated that human umbilical cord mesenchymal stem cells (HUMSCs) were capable of differentiation into germ cells in vitro. To assess this potential in vivo, HUMSCs were microinjected into the lumen of seminiferous tubules of immunocompetent mice, which were treated with busulfan to destroy endogenous spermatogenesis. [Mol Med Rep] Abstract | Download Full Article

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REVIEWS
Novel Clinical Uses for Cord Blood Derived Mesenchymal Stromal Cells
The field of stem cell biology has identified a number of stem cell sources including embryonic stem cells and adult stem cells that offer the potential to replace virtually all functional cells of the body. The authors discuss the potential of mesenchymal stromal cells from cord blood for regenerative medicine approaches. [Cytotherapy] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
INDUSTRY NEWS
Cordlife Partners with Sutter Neuroscience Institute to Treat Childhood Autism Using Cord Blood Stem Cells
Cordlife India has partnered with Dr. Michael Chez, autism and epilepsy treatment pioneer from Sutter Neuroscience Institute to study the treatment of childhood autism using cord blood stem cells. [Cordlife India] Press Release

BioLineRx Reports Successful Top-Line Safety and Efficacy Results for Novel Stem Cell Mobilization Treatment
BioLineRx Ltd. announced successful top-line results from the Phase I safety and efficacy study of its lead clinical candidate, BL-8040, as a novel approach for mobilization and collection of bone-marrow stem cells from the peripheral blood circulation. [BioLineRx Ltd.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Frontiers in Stem Cells and Regeneration
September 27-October 3, 2015
Woods Hole, United States

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Research Fellow – Hematopoietic Stem Cell Biology (University of Leuven)

Research Associate – Hematopoietic and Leukemic Stem Cells (Shanghai Jiao-Tong University School of Medicine)

Research Scientist – Cell Signaling in Normal and Leukemic Hematopoietic Stem and Progenitor Cells (Indiana University)

Manufacturing Manager – Cell Therapy (Opexa Therapeutics)

Postdoctoral Fellows – Leukemia Research and Stem Cell Biology (Josep Carreras Leukemia Research Institute)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Cord Tissue Processing Technician (Cord Blood Registry)


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