Volume 7.17 | May 7

Cord Blood News 7.17 May 7, 2015
Cord Blood News
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Extra-Hepatic Sources of FVIII Potentially Contribute to the Coagulation Cascade Correcting the Bleeding Phenotype of Hemophilia A Mice
To further establish the role of blood cells in expressing FVIII, the authors studied various mouse and human hematopoietic cell types. They identified FVIII in cells isolated from peripheral and cord blood, as well as bone marrow. [Haematologica] Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Role of Nonmuscle Myosin II in Migration of Wharton’s Jelly-Derived Mesenchymal Stem Cells
Investigators attempted to identify the role of nonmuscle myosin II (NMII), if any, in migration of Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs). Expression of NMII isoforms, NMIIA and NMIIB, was observed both at RNA and protein levels in WJ-MSCs. [Stem Cells Dev] Abstract

Isolation of Human Neural Stem Cells from the Amniotic Fluid with Diagnosed Neural Tube Defects
Researchers describe an efficient method to isolate and propagate human neural stem cells (NSCs) from the amniotic fluid with diagnosed neural tube defects, specifically, anencephaly. These amniotic fluid-derived NSCs formed neurospheres and underwent long-term expansion in vitro. [Stem Cells Dev] Abstract

Human Umbilical Cord Mesenchymal Stem Cell Transplantation Restores Damaged Ovaries
Scientists investigated transplantation methods for human umbilical cord mesenchymal stem cells can recover ovarian function that has been damaged by chemotherapy. [J Cell Mol Med] Full Article

Placental Mesenchymal Stromal Cells Rescue Ambulation in Ovine Myelomeningocele
Researchers demonstrated that using early gestation human placenta-derived mesenchymal stromal cells to augment in utero repair of myelomeningocele (MMC) results in significant and consistent improvement in neurologic function at birth in the rigorous fetal ovine model of MMC. [Stem Cells Transl Med] Abstract

Human Umbilical Cord Matrix Mesenchymal Stem Cells Suppress the Growth of Breast Cancer by Expression of Tumor Suppressor Genes
Comparative analyses of two types of umbilical cord matrix mesenchymal stem cells (UCMSC) suggest that rat UCMSC-dependent growth regulation is significantly stronger than that of human UCMSC. Comparative analyses of two types of UCMSC suggest that rat UCMSC-dependent growth regulation is significantly stronger than that of human UCMSC. [PLoS One] Full Article

Second Allogeneic Transplantation Using Unrelated Cord Blood for Relapsed Hematological Malignancies after Allogeneic Transplantation
Investigators analyzed the results of second allogeneic stem cell transplantation using single-unit unrelated cord blood in 34 adult patients with relapsed hematological malignancies after initial allogeneic stem cell transplantation in their institution. [Leuk Lymphoma] Abstract

Feeder-Free and Xeno-Free Culture of Human Pluripotent Stem Cells Using UCBS Matrix
Researchers established a new feeder-free and xeno-free system for culturing human pluripotent stem cells. The system consists of the matrix, which was prepared from human umbilical cord blood serum (UCBS) and used to coat the culture plates, and the xeno-free medium, which was conventional serum-free hES medium supplemented with high concentrations of bFGF and fibronectin. [Cell Biol Int] Abstract

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Human Mesenchymal Stem Cells – Current Trends and Future Prospective
The authors highlight recent research findings in the area of human mesenchymal stem cells sources, expression of cell surface markers, long-term in vitro culturing, in vitro differentiation potential, immunomodulatory features, its homing capacity, banking and cryopreservation, its application in the treatment of chronic diseases and its use in clinical trials. [Biosci Rep] Full Article

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BioLineRx Initiates Expansion Stage of Phase II Clinical Trial for Novel Treatment for Acute Myeloid Leukemia
BioLineRx Ltd. announced successful completion of the dose escalation stage of its ongoing Phase II study of BL-8040, and commencement of the expansion stage at the optimal dose of this novel treatment for acute myeloid leukemia. [BioLineRx Ltd.] Press Release

Generon Received US FDA Clearance to Initiate Phase IIa Study with F-652, a First-in-Class Biologic, to Treat Patients with Acute GvHD
Generon Corporation announced that it received US FDA clearance of the IND for a Phase IIa study, entitled “Recombinant Human Interleukin-22-IgG2-Fc (F-652) in Combination with Systemic Corticosteroids for the Treatment of Newly Diagnosed Grade II-IV Lower Gastrointestinal Acute Graft-versus-Host Disease in Hematopoietic Stem Cell Transplantation Recipients.” [Generon (Shanghai) Corporation Ltd.]
Press Release | Clinical Trial

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 13th International Conference on Malignant Lymphoma (ICML)
June 17-20, 2015
Lugano, Switzerland

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NEW Postdoctoral Scientist – Hematopoiesis (University of Oxford)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Hematopoietic Stem Cell Physiology and Pathophysiology (International Research Center for Medical Sciences)

Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford-Burnham Medical Research Institute)

Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Leuven)

Postdoctoral Fellow – Hematopoietic Stem Cell Research (Lund University)

Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

Postdoctoral Fellows – Leukemia Research and Stem Cell Biology (Josep Carreras Leukemia Research Institute)

Cord Tissue Processing Technician (Cord Blood Registry)

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