Non-Steady-State Hematopoiesis Regulated by the C/EBPβ Transcription Factor|
The BCR-ABL fusion protein activates emergency-specific pathway of granulopoiesis by up-regulating C/EBPβ. This in turn causes chronic phase chronic myeloid leukemia, which is characterized by myeloid expansion. C/EBPβ also plays a role in other hematological malignancies of both myeloid- and lymphoid lineage-origin. [Cancer Sci] Abstract
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