Volume 7.19 | May 21

Cord Blood News 7.19 May 21, 2015
Cord Blood News
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Human Placenta-Derived Cells (PDA-001) for the Treatment of Moderate-To-Severe Crohn’s Disease: A Phase Ib/IIa Study
Subjects received eight units of PDA-001, a preparation of placenta-derived mesenchymal-like adherent cells with immunomodulatory effects, in the Phase IIb open-label study. A two-infusion regimen of PDA-001 induced clinical response in subjects with moderate-to-severe Crohn’s disease. [Inflamm Bowel Dis] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Propagation of Pure Fetal and Maternal Mesenchymal Stromal Cells from Terminal Chorionic Villi of Human Term Placenta
Scientists demonstrated the presence of fetal and maternal cells within the tips of terminal chorionic villi of normal human term placenta, and they exploited inherent differences in the adhesive and migratory properties of maternal versus fetal cells, to establish pure mesenchymal stromal cell cultures of both cell types. [Sci Rep] Full Article

Involvement of Immune Responses in the Efficacy of Cord Blood Cell Therapy for Cerebral Palsy
The authors evaluated the efficacy of umbilical cord blood cell for patients with cerebral palsy in a randomized, placebo-controlled, double-blind trial and also assessed factors and mechanisms related to the efficacy. [Stem Cells Dev] Abstract

Direct Conversion of Cord Blood CD34+ Cells into Neural Stem Cells by OCT4
Researchers report a method to generate neural stem cells from cord blood CD34-positive cells by ectopic expression of OCT4 in a feeder-free system. [Stem Cells Transl Med] Abstract

Effect of Human Umbilical Cord Blood Derived Lineage Negative Stem Cells Transplanted in Amyloid-β Induced Cognitive Impaired Mice
The authors examined the therapeutic efficacy of human umbilical cord blood derived lineage negative stem cells in alleviating behavioral and neuropathological deficits in a mouse model of cognitive impairment induced by bilateral intrahippocampal injection of amyloid-β. [Behav Brain Res] Abstract

Effect of Granulocyte Colony-Stimulating Factor Combined Conditioning in Cord Blood Transplantation for Myelodysplastic Syndrome and Secondary Acute Myeloid Leukemia: A Retrospective Study in Japan
Scientists conducted a retrospective nationwide study of 336 adult patients with myelodysplastic syndrome and secondary acute myeloid leukemia after single-unit cord blood transplantation. [Biol Blood Marrow Transplant] Abstract

The Use of Human Amniotic Fluid Stem Cells as an Adjunct to Promote Pulmonary Development in a Rabbit Model for Congenital Diaphragmatic Hernia
The authors evaluated the potential benefit of intra-tracheal injection of human amniotic fluid stem cells on pulmonary development combined with TO in a rabbit model for congenital diaphragmatic hernia. [Prenat Diagn] Abstract

Ex Vivo and In Vivo Modulatory Effects of Umbilical Cord Wharton’s Jelly Stem Cells on Human Oral Mucosa Stroma Substitutes
Researchers generated human oral mucosa substitutes with oral mucosa keratinocytes and human umbilical cord Wharton’s jelly stem cells to determine the influence of these cell sources on stromal differentiation. [Histol Histopathol] Abstract | Full Article

In Vitro Generation of Functional Dendritic Cells Differentiated from CD34 Negative Cells Isolated from Human Umbilical Cord Blood
Scientists used CD34 antibody to isolate CD34+ and CD34 cells and compared the ability to differentiate into dendritic cells. They used a two-step method combined with the magnetic bead sorting system to isolate CD34+ and CD34 cells from human umbilical cord blood. [Cell Biol Int] Abstract

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Advances in Umbilical Cord Blood Stem Cell Expansion and Clinical Translation
The authors review past and current strategies, focusing on studies that characterized the contribution of expanded cord blood hematopoietic stem cells to short- and long-term engraftment in transplantation models or in clinical trials. [Exp Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
UB and Roswell Park Receive $1.85 Million Grant to Launch Stem Cell Research Program
University at Buffalo (UB) and Roswell Park Cancer Institute researchers have been awarded a $1.85 million grant to create an interdisciplinary stem cell research training program. The program, called Stem Cells in Regenerative Medicine, will bring together 18 faculty members in UB’s School of Engineering and Applied Sciences and the School of Medicine and Biomedical Sciences, and Roswell Park’s Graduate Division. [University of Buffalo] Press Release

EMA Grants Kiadis Pharma’s Lead Product ATIR™ ATMP Certificate for Quality and Non-Clinical Data
Kiadis Pharma B.V. announced that its lead product ATIR™ for blood cancers has been granted an Advanced Therapy Medicinal Product (ATMP) certificate for manufacturing quality and non-clinical data by the European Medicines Agency (EMA) [Kiadis Pharma B.V.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 25th Annual Mayo Clinic Hematology/Oncology Reviews
July 29-August 1, 2015
Amelia Island, United States

Visit our events page to see a complete list of events in the cord blood community.
NEW Assistant Member/Assistant Professor – Cord Blood (Fred Hutchinson Cancer Research Center)

NEW Head of Cellular Therapies Laboratory (NHS Blood and Transplant)

NEW Postdoctoral Position – Epigenetic Regulation of Hematopoiesis and Leukemia (Karolinska Institutet)

NEW Postdoctoral Position – Genetic Engineering and Transplantation of Hematopoietic Stem Cells (University of California, San Francisco)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Researcher – Hematopoietic Stem Cell Physiology and Pathophysiology (International Research Center for Medical Sciences)

Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford-Burnham Medical Research Institute)

Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

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