Volume 7.20 | May 28

Cord Blood News 7.20 May 28, 2015
Cord Blood News
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Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity
Scientists generated induced neural progenitor cells (NPCs) from neonatal and adult peripheral blood using single-factor OCT4 reprogramming. Unlike fibroblasts that share molecular hallmarks of neural crest, OCT4 reprogramming of blood was facilitated by SMAD+GSK-3 inhibition to overcome restrictions on neural fate conversion. [Cell Rep] Full Article | Graphical Abstract | Press Release 
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PUBLICATIONS (Ranked by impact factor of the journal)
Transplantation of Mesenchymal Stem Cells Ameliorates Secondary Osteoporosis through Interleukin-17-Impaired Functions of Recipient Bone Marrow Mesenchymal Stem Cells in MRL/Lpr Mice
Scientists transplanted human bone marrow mesenchymal stem cells and stem cells from exfoliated deciduous teeth into MRL/lpr mice and explored their therapeutic mechanisms in secondary osteoporotic disorders of systemic lupus erythematosus model mice. [Stem Cell Res Ther] Abstract | Full Article

Umbilical Cord Blood Plasma Contains Soluble NKG2D Ligands That Mediate Loss of Natural Killer Cell Function and Cytotoxicity
Investigators found that soluble NKG2D ligands are present in cord blood plasma and associated with adult NK cell hyporesponsiveness demonstrated by reduced CD107a expression and secretion of IFN-γ upon stimulation. [Eur J Immunol] Abstract

Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy
Researchers showed a significant step-wise downregulation of hsa-miR-374a expression in cord blood of infants with perinatal asphyxia and subsequent hypoxic ischemic encephalopathy. [J Pediatr] Abstract

Hepatic Differentiation of Human Amniotic Epithelial Cells and In Vivo Therapeutic Effect on Animal Model of Cirrhosis
With hepatic differentiation, human amniotic epithelial cells assumed a hepatocytic polygonal morphology with up regulation of transcription factors responsible for liver specification. [J Gastroenterol Hepatol] Abstract

Microarray Expression Profile Analysis of Long Non-Coding RNAs in Umbilical Cord Plasma Reveals their Potential Role in Gestational Diabetes-Induced Macrosomia
The authors investigated the umbilical cord long non-coding RNA (lncRNA) profiles in gestational diabetes mellitus (GDM) macrosomia. A microarray identified 8814 lncRNAs that were expressed in the umbilical cord blood, of which 349 were significantly upregulated and 892 were significantly downregulated in the GDM group. [Cell Physiol Biochem] Full Article

Complement-Binding Donor-Specific Anti-HLA Antibodies and Risk of Primary Graft Failure in Hematopoietic Stem Cell Transplantation
Researchers hypothesized that complement-binding donor-specific anti-HLA antibodies (DSA) are associated with engraftment failure in hematopoietic stem-cell transplantation and analyzed 122 haploidentical transplant recipients tested prospectively for DSA. [Biol Blood Marrow Transplant] Abstract

Second Allogeneic Transplantation Using Unrelated Cord Blood for Relapsed Hematological Malignancies after Allogeneic Transplantation
Researchers analyzed the results of second allogeneic stem cell transplantation using a single-unit of unrelated cord blood in 34 adult patients with relapsed hematological malignancies after second allogeneic stem cell transplantation. [Leuk Lymphoma] Abstract

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Development and Trafficking Function of Hematopoietic Stem Cells and Myeloid Cells during Fetal Ontogeny
The authors provide an overview of fetal hematopoiesis as well as trafficking of hematopoietic stem cells during fetal life. In addition, they focus on the appearance of the first differentiated myeloid cells in the fetal circulation and describe how they acquire the ability to roll, adhere and transmigrate into inflamed fetal tissue. [Cardiovasc Res] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

13th International Cord Blood Symposium
GlycoMimetics Initiates Phase I/II Clinical Trial of GMI-1271 as Potential Treatment for Acute Myeloid Leukemia in Combination with Chemotherapy
GlycoMimetics, Inc. announced that the first patient has been dosed in a Phase I/II clinical study designed to evaluate the safety, pharmacokinetics and efficacy of GMI-1271, a novel and proprietary E-selectin antagonist in the company’s pipeline, when used in combination with chemotherapy in patients with acute myeloid leukemia. [GlycoMimetics, Inc.] Press Release

BMO Announces $1 Million Donation to Stem Cell and Regenerative Medicine Research
BMO Financial Group announced a $1 million donation to support ongoing stem cell and regenerative medicine research in Canada. [BMO] Press Release

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NEW International Conference on Advances in Hematology and Oncology
August 28-29, 2015
Coeur d’Alene, United States

Visit our events page to see a complete list of events in the cord blood community.
NEW Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

NEW Postdoctoral Scientist – Hematopoietic Stem Cell Transplantation (Indiana University)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Head of Cellular Therapies Laboratory (NHS Blood and Transplant)

Postdoctoral Position – Epigenetic Regulation of Hematopoiesis and Leukemia (Karolinska Institutet)

Postdoctoral Position – Genetic Engineering and Transplantation of Hematopoietic Stem Cells (University of California, San Francisco)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Researcher – Hematopoietic Stem Cell Physiology and Pathophysiology (International Research Center for Medical Sciences)

Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford-Burnham Medical Research Institute)

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