Volume 7.22 | Jun 11

Cord Blood News 7.22 June 11, 2015
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Lead Exposure Induces Changes in 5-Hydroxymethylcytosine Clusters in CpG Islands in Human Embryonic Stem Cells and Umbilical Cord Blood
Scientists randomly selected umbilical cord blood from 24 male and 24 female children from the 1st and 4th quartiles of lead (Pb) levels. They showed that Pb-associated changes in the 5-hydroxymethylcytosine and DNA methylation profiles can be divided into sex-dependent and sex-independent categories. [Epigenetics] Abstract
MethoCult: The most published medium for mouse hematopoietic colony-forming unit (CFU) assays. Click here to learn more.
 
PUBLICATIONS (Ranked by impact factor of the journal)
Outcomes of Acute Leukemia Patients Transplanted with Naive T Cell-Depleted Stem Cell Grafts
Researchers hypothesized that selective depletion of naive T cells from human allogeneic peripheral blood stem cell grafts would reduce graft-versus-host disease and provide sufficient numbers of hematopoietic stem cells and memory T cells to permit hematopoietic engraftment and the transfer of pathogen-specific T cells from donor to recipient, respectively. [J Clin Invest] Full Article

Antioxidant Treatment Enhances Human Mesenchymal Stem Cell Anti-Stress Ability and Therapeutic Efficacy in an Acute Liver Failure Model
Researchers demonstrated the pivotal role of antioxidant levels in human umbilical cord mesenchymal stem cells dynamic in vitro anti-stress abilities against lipopolysaccharide (LPS)/H2O2 intoxication and in vivo therapeutic efficacy in a murine acute liver failure model induced by D-galactosamine/LPS by either reducing the antioxidant levels with diethyl maleate or increasing antioxidant levels with edaravone. [Sci Rep] Full Article

Characterization of HLA-G and Related Immunosuppressive Effects in Human Umbilical Cord Stroma Derived Stem Cells
Scientists explored the immunosuppressive properties of human umbilical cord mesenchymal stem cells (HUCMSCs). They found that HLA-G was much more expressed on the HUCMSCs than mesenchymal stem cells of other origins. [Cell Transplant] Abstract

High Concentrations of TNF-α Induce Cell Death during Interactions between Human Umbilical Cord Mesenchymal Stem Cells and Peripheral Blood Mononuclear Cells
The authors explored the role of TNF-α in the interactions between human umbilical cord mesenchymal stromal cells and peripheral blood mononuclear cells. [PLoS One] Full Article

Quantitative Characterization of T-Cell Repertoire in Allogeneic Hematopoietic Stem Cell Transplant Recipients
Investigators characterized the T repertoire in patients who underwent matched donor or haplo-cord hematopoietic stem cell transplantation using next-generation sequencing approach. [Bone Marrow Transplant] Abstract

Altered Expression of MicroRNAs in the Neuronal Differentiation of Human Wharton’s Jelly Mesenchymal Stem Cells
Researchers isolated mesenchymal stem cells from the Wharton’s jelly of the human umbilical cord (WJ-MSCs), and efficiently induced WJ-MSCs into neuron-like cells using a modified method. [Neurosci Lett] Abstract

Key Immune Cell Cytokines Have a Significant Role in the Expansion of CD26 Population of Cord Blood Mononuclear Cells
Researchers aimed to investigate the effect of key immune cell cytokines on CD26 expansion. They showed that utilization of interleukin (IL) 7 significantly improved the expression of total CD26+ cells and when either IL2 or IL15 were added to the culture, the expression also improved 2.5-fold. [Artif Cells Nanomed Biotechnol] Abstract

Going to ISSCR 2015? We’ll see you there!
 
REVIEWS
Umbilical Cord Blood Graft Engineering: Challenges and Opportunities
Scientists are entering a very exciting era in umbilical cord blood transplantation (UCBT), where many of the associated formidable challenges may become treatable by ex vivo graft manipulation and/or adoptive immunotherapy utilizing specific cellular products. [Bone Marrow Transplant] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
INDUSTRY NEWS
Sanford Consortium, Takeda Pharmaceutical Partner in $10-Million “Innovation Alliance”
The Sanford Consortium for Regenerative Medicine and the Takeda Pharmaceutical Company Limited have agreed to establish a $10-million, five-year Innovation Alliance that would advance each organization’s research missions. [UC San Diego] Press Release

STEMCELL Technologies Named Company of the Year by BIOTECanada
STEMCELL Technologies Inc. will be presented with the Biotech Company of the Year award by BIOTECanada at this year’s BIO International Convention in Philadelphia. [BIOTECanada] Press Release

From our sponsor: Induce neural progenitor cells faster and more effectively. Watch the technical video.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 2015 Midwest Conference on Cell Therapy & Regenerative Medicine
September 18-19, 2015
Kansas City, United States

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Hematopoietic Stem Cell Biology (Harvard Medical School)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Assistant/Associate Professor – Hematologic Malignancies (MD Anderson Cancer Center)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Postdoctoral Scientist – Hematopoietic Stem Cell Transplantation (Indiana University)

Postdoctoral Position – Epigenetic Regulation of Hematopoiesis and Leukemia (Karolinska Institutet)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Researcher – Hematopoietic Stem Cell Physiology and Pathophysiology (International Research Center for Medical Sciences)

Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford-Burnham Medical Research Institute)


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