Volume 7.26 | Jul 9

Cord Blood News 7.26 July 9, 2015
Cord Blood News
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Osteogenic/Angiogenic Dual Growth Factor Delivery Microcapsules for Regeneration of Vascularized Bone Tissue
When dual growth factor-loaded microcapsules (MCs) were assessed for in vitro osteogenesis of umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) on 2D and 3D environments, MCs contributed to much better UCB-MSCs osteogenesis as confirmed by von Kossa staining, immunofluorescence, calcium content measurement, and osteogenic markers expression. [Adv Healthc Mater] Abstract
MethoCult: The most published medium for mouse hematopoietic colony-forming unit (CFU) assays. Click here to learn more.
PUBLICATIONS (Ranked by impact factor of the journal)
Long-Term Outcome of a Phase II Trial with Nilotinib 400 Mg Twice Daily in First-Line Treatment of Chronic Myeloid Leukemia
The authors report the long-term, six-year, results of the first investigator-sponsored, GIMEMA multicenter Phase II, single-arm, trial with nilotinib 400 mg twice daily as first-line treatment in 73 chronic-phase chronic myeloid leukemia patients. [Haematologica] Abstract

Impact of the Source of Hematopoietic Stem Cell in Unrelated Transplants: Comparison between 10/10, 9/10-HLA Matched Donors and Cord Blood
Investigators compared the outcome of patients transplanted from unrelated cord blood with those transplanted from 9/10-HLA mismatched unrelated donors or 10/10-HLA matched related or unrelated donor. [Am J Hematol] Abstract

Isolation of Foreign Material-Free Endothelial Progenitor Cells Using CD31 Aptamer and Therapeutic Application for Ischemic Injury
To utilize apatmers for isolation of endothelial progenitor cells (EPCs), investigators successfully generated aptamers that recognize human CD31, an endothelial cell marker. CD31 aptamers bound to human umbilical cord blood-derived EPCs and showed specific interaction with human CD31, but not with mouse CD31. [PLoS One] Full Article

Comparable Outcome after Single-Antigen-Mismatched versus Matched Unrelated Donor Haematopoietic Cell Transplantation
The impact of donor matching on outcome of unrelated hematopoietic stem cell transplantation was analyzed in patients transplanted at the University of Leipzig. [J Cancer Res Clin Oncol] Abstract

Umbilical Cord-Derived Mesenchymal Stem Cells Promote Proliferation and Migration in MCF-7 and MDA-MB-231 Breast Cancer Cells through Activation of the ERK Pathway
Mesenchymal stem cells (MSCs) were isolated and identified from umbilical cord tissues. MDA-MB‑231 and MCF-7 cells were treated with conditioned medium from 10 and 20% umbilical cord MSCs, and the resulting changes in proliferation and migration were investigated. [Oncol Rep] Abstract

Isolation of Mesenchymal Stromal/Stem Cells from Small-Volume Umbilical Cord Blood Units that Do Not Qualify for the Banking System
Scientists examined the availability of freshly donated umbilical cord blood units that do not qualify for the Japanese banking system for transplantation because of their small volume as a source of mesenchymal stem cells. [Int J Hematol] Abstract

Coadministration of the Human Umbilical Cord Matrix-Derived Mesenchymal Cells and Aspirin Alters Postischemic Brain Injury in Rats
Scientists evaluated the protective potential of implanted human umbilical cord mesenchymal stem cells with/without aspirin against focal cerebral ischemia. [J Stroke Cerebrovasc Dis] Abstract

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The Role and Potential of Umbilical Cord Blood in an Era of New Therapies: A Review
The authors review many issues surrounding the conservation of umbilical cord blood (UCB)-derived cells and the great potential and current clinical applications of UCB in an era of new therapies. [Stem Cell Res Ther] Full Article

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AMAG Pharmaceuticals to Acquire Cord Blood Registry
AMAG Pharmaceuticals, Inc. announced that it has entered into a definitive agreement to acquire Cord Blood Registry®, the world’s largest stem cell collection and storage company serving pregnant women and their families, for $700 million. [Cord Blood Registry®] Press Release

Amarna Therapeutics Teaming Up with Austrian CBmed in the Development of Immunotherapies
Amarna Therapeutics announced that it has entered into a cooperation with Austrian Center for Biomarker Research in Medicine (CBmed), for the development of immunotherapies against acute lymphoblastic leukemia, obesity, diabetes mellitus type 2 and atherosclerotic cardiovascular disease. [Amarna Therapeutics B.V.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Biobanking 2016
January 5-7, 2016
London, United Kingdom

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NEW Data Coordinator – Hematological Malignancies (Fred Hutchinson Cancer Research Center)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Clinical Research Coordinator – Chronic Lymphocytic Leukemia (Fred Hutchinson Cancer Research Center)

Director of Stem Cell Transplantation (University of Virginia)

Regulatory Coordinator – Leukemia Research (Weill Cornell College of Medicine)

PhD Position – Drug Releasing, Nanostructured Biomaterials for Adult Stem Cells (Karlsruhe Institute of Technology)

Postdoctoral Fellow – Hematopoietic Stem Cell Biology (Harvard Medical School)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Postdoctoral Position – Epigenetic Regulation of Hematopoiesis and Leukemia (Karolinska Institutet)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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