Volume 7.32 | Aug 20

Cord Blood News 6.32 August 20, 2015
Cord Blood News
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Chorion Mesenchymal Stem Cells Show Superior Differentiation and Immunosuppressive and Angiogenic Potential Comparison with Haploidentical Maternal Placental Cells
Researchers analyzed the biological characteristics of haploidentical mesenchymal stem cells (MSCs) isolated from fetal sources, including the umbilical cord-MSCs and chorion-MSCs, compared with maternal decidua MSCs. [Stem Cells Transl Med] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Clofarabine Salvage Therapy Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Relapsed or Refractory AML
Researchers studied the safety and efficacy of clofarabine-based salvage therapy. The study was designed as a Phase II, multi-center, intent-to-transplant study. [Leukemia] Abstract

Allogeneic Hematopoietic Stem Cell Transplantation for Mitochondrial Neurogastrointestinal Encephalomyopathy
Investigators conducted a retrospective analysis of all known patients suffering from mitochondrial neurogastrointestinal encephalomyopathy who underwent allogeneic hematopoietic stem cell transplantation between 2005 and 2011. [Brain] Abstract

Transplantation of Placenta-Derived Mesenchymal Stem Cells Enhances Angiogenesis after Ischemic Limb Injury in Mice
The authors showed that placenta-derived mesenchymal stem cell treatment significantly enhanced microvessel density, improved blood perfusion and diminished pathologies in ischemic mouse hindlimbs as compared to those in the control group. [J Cell Mol Med] Abstract | Full Article

Enhancement of the Immunoregulatory Potency of Mesenchymal Stromal Cells by Treatment with Immunosuppressive Drugs
With the use of a pre-clinical model of acute graft-versus-host disease, scientists demonstrated that a low dose of rapamycin-treated but not untreated umbilical cord–derived mesenchymal stromal cells significantly inhibited the onset of disease. [Cytotherapy] Abstract | Full Article

A Simple, Rapid, and Efficient Method for Isolating Mesenchymal Stem Cells from the Entire Umbilical Cord
Scientists present a modulated explant/enzyme method to isolate the maximum number of mesenchymal stem cells from the entire umbilical cord. [Cell Transplant] Abstract

The Targeted Inhibitory Effects of Human Amniotic Fluid Stem Cells Carrying CXCR4 Promoter and DAL-1 on Non-Small Cell Lung Carcinoma Growth
Investigators determined the targeted effects of human amniotic fluid stem cells carrying CXCR4 promoter driven conditionally replicable adenovirus vector over-expressing differentially expressed in adenocarcinoma of the lung-1 (DAL-1) on non-small cell lung carcinoma growth. [Gene Ther] Abstract

Intranasal Administration of Human Umbilical Cord Mesenchymal Stem Cells-Conditioned Medium Enhances Vascular Remodeling after Stroke
Researchers investigated whether intranasal administration of human umbilical cord mesenchymal stem cells-condition medium has the therapeutic effects in rats after stroke. [Brain Res] Abstract

Effects of Magnesium Degradation Products on Mesenchymal Stem Cell Fate and Osteoblastogenesis
To mimic the in vivo effects of the degradation of magnesium-based implants on mesenchymal stem cell differentiation during bone remodeling, non-hematopoietic multipotent fetal progenitor cells, i.e., human umbilical cord perivascular cells, were cultured for up to three weeks with or without osteoblastic differentiating media and with or without magnesium extract [Gene] Abstract

Standardize Your CFU Assays With STEMvision for Automated CFU Assay Imaging and Analysis
Mesenchymal Cells of Umbilical Cord and Umbilical Cord Blood as a Source of Human Oligodendrocyte Progenitors
The authors present foregoing achievements in oligodendrocyte generation from stem cells of umbilical cord, either fresh or cryopreserved, and their utility for cellular therapies. [Life Sci] Abstract | Graphical Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

IBC’s Cell Therapy Bioprocessing & Commercialization meeting
NYBC Partners with UC Davis Health System to Produce More Viable Stem Cell Therapies
New York Blood Center (NYBC) announced a new collaboration with the University of California, Davis, Health System to manufacture specialized lines of stem cells as potential therapies for repair and regeneration of retina, kidney, lung and liver tissue, as well as for the treatment of neurodegenerative disorders such as Parkinson’s, Alzheimer’s and Huntington’s disease. [New York Blood Center] Press Release

Phase II Study of Venetoclax in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia with 17p Deletion Meets Primary Endpoint
AbbVie announced that a Phase II trial of its investigational medicine venetoclax met its primary endpoint of achieving overall response rates in patients with relapsed/refractory or previously untreated chronic lymphocytic leukemia with 17p deletion, according to an independent review analysis. [AbbView Inc.] Press Release

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National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 3rd Annual Cell Culture & Bioprocessing Asia Congress 2015
October 15-16, 2015
Singapore, Singapore

Visit our events page to see a complete list of events in the cord blood community.
NEW Assistant Member – Cord Blood (Fred Hutchinson Cancer Research Center)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Postdoctoral Fellowship – Leukemia (Stanford University School of Medicine)

Laboratory Technologist – Cord Blood and Cord Tissue Bank (Texas Stem Cell)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

Research Associate – Cell Biology (Editas Medicine)

Independent Junior Group Leader – Lymphopoiesis or Gene Regulation/Nuclear Architecture in the Hematopoietic System (Max-Planck-Institute)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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