Volume 7.33 | Aug 27

Cord Blood News 7.33 August 27, 2015
Cord Blood News
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MiR-126 Contributes to Human Umbilical Cord Blood Cell Induced Neurorestorative Effects after Stroke in Type-2 Diabetic Mice
Scientists tested the neurorestorative effects of delayed human umbilical cord blood cell (HUCBC) treatment of stroke in type-2 diabetes. Delayed HUCBC-treatment of stroke increased vascular/white-matter remodeling and anti-inflammatory effects. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
The Pre-Vascularization of a Collagen-Chondroitin Sulphate Scaffold Using Human Amniotic Fluid-Derived Stem Cells to Enhance and Stabilize Endothelial Cell-Mediated Vessel Formation
The authors investigated whether an amniotic fluid-derived stem cell-human umbilical vein endothelial cell co-culture could be used to engineer in vitro vasculature in a collagen chondroitin sulphate scaffold. [Acta Biomater] Abstract

Molecular and Cellular Characteristics of Human and Non-Human Primate Multipotent Stromal Cells from the Amnion and Bone Marrow during Long Term Culture
Human and non-human primate multipotent stromal cells (MSCs) were characterized for expression of MSC markers and capability of differentiation into mesenchymal lineages. The authors found that human and common marmoset samples shared many similar features such as most MSC markers and reduced major histocompatibility complex class I expression in amnion cells vs. bone marrow. [Stem Cell Res Ther] Full Article

Optimal Route for Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Transplantation to Protect against Neonatal Hyperoxic Lung Injury: Gene Expression Profiles and Histopathology
Scientists determined the optimal route of mesenchymal stem cell (MSC) transplantation. Gene expression profiling was performed to compare the effects of intratracheal versus intravenous MSC administration. [PLoS One] Full Article

Amniotic Fluid Derived Stem Cells with a Renal Progenitor Phenotype Inhibit Interstitial Fibrosis in Renal Ischemia and Reperfusion Injury in Rats
Investigators evaluated if mesenchymal stem cells derived from human amniotic fluid with a renal progenitor phenotype demonstrated a nephroprotective effect in acute ischemia reperfusion model and prevented late stage fibrosis. [PLoS One] Full Article

Endothelial Progenitor Cells, Defined by the Simultaneous Surface Expression of VEGFR2 and CD133, Are Not Detectable in Healthy Peripheral and Cord Blood
Scientists carried out an in depth investigation of circulating endothelial cell and their progenitor phenotypes in healthy peripheral blood, cord blood and bone marrow samples, by optimizing a reliable polychromatic flow cytometry panel. [Cytometry A] Abstract

Hematopoietic Stem Cell Transplantation for CD40 Ligand Deficiency: Single Institution Experience
Researchers conducted a retrospective analysis of seven patients who have undergone allogeneic hematopoietic stem cell transplantation (HSCT) for hyper-IgM syndrome syndrome. Allogeneic HSCT resulted in excellent survival and sustained immune reconstitution in patients with CD40 ligand deficiency using both myeloablative and reduced intensity conditioning approaches and various graft sources, including bone marrow, peripheral blood, and umbilical cord blood. [Pediatr Blood Cancer] Abstract

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Modern Approaches to HLA-Haploidentical Blood or Marrow Transplantation
The authors provide an overview of the three most-developed approaches to HLA-haploidentical allogeneic blood or bone-marrow transplantation: T-cell depletion with ‘megadose’ CD34+ cells; granulocyte colony-stimulating factor-primed allografts combined with intensive pharmacological immunosuppression, including antithymocyte globulin; and high-dose, post-transplantation cyclophosphamide. [Nat Rev Clin Oncol] Abstract

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AMAG Pharmaceuticals Completes Acquisition of Cord Blood Registry
AMAG Pharmaceuticals, Inc. announced that it has completed the acquisition of Cord Blood Registry® for $700 million in cash. [UC San Diego Health] Press Release

Pluristem Granted U.S. Patent for Production Methods and Use of Placental Cell Therapy in a Range of Indications
Pluristem Therapeutics Inc. announced that the U.S. Patent and Trademark Office has issued to the company patent #9,096,827 titled “Adherent Cells From Placenta Tissue and Use Thereof in Therapy.” [Pluristem Therapeutics Inc.] Press Release

Esperite Acquires Patent to Use MSC-Derived Exosomes for Broad Applications in Immunology
Esperite has acquired the full rights of a broad international patent enabling MSC-derived exosomes use in treatment of inflammatory and autoimmune diseases. This exosome technology will permit development of more effective, safer and affordable therapies as an alternative to allogeneic MSCs. [Esperite N.V.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Hematopoietic Stem Cells: From the Embryo to the Aging Organism
June 3-5, 2016
Heidelberg, Germany

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NEW Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Assistant Member – Cord Blood (Fred Hutchinson Cancer Research Center)

Laboratory Technologist – Cord Blood and Cord Tissue Bank (Texas Stem Cell)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

Research Associate – Cell Biology (Editas Medicine)

Independent Junior Group Leader – Lymphopoiesis or Gene Regulation/Nuclear Architecture in the Hematopoietic System (Max-Planck-Institute)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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