Volume 7.34 | Sep 3

Cord Blood News 7.34 September 3, 2015
Cord Blood News
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MLL Leukemia Induction by Genome Editing of Human CD34+ Hematopoietic Cells
Scientists applied TALEN-mediated genome editing to generate endogenous mixed-lineage leukemia (MLL)-AF9 and MLL-ENL oncogenes through insertional mutagenesis in primary human hematopoietic stem and progenitor cells derived from human umbilical cord blood. [Blood] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Is There a Stronger Graft-versus-Leukemia Effect Using HLA-Haploidentical Donors than with HLA-Identical Siblings?
Scientists analyzed 10,679 acute leukemia patients who underwent HSCT from an HLA-matched sibling donor or a haploidentical donor between 2007 and 2012 [Leukemia] Abstract

Telomere Homeostasis in Trophoblasts and in Cord Blood Cells from Pregnancies Complicated with Preeclampsia
Researchers studied mechanisms of telomere shortening in trophoblasts from pregnancies complicated with preeclampsia (PE) and assessed telomere length and homeostasis in fetal cord blood cells from PE pregnancies. [Am J Obstet Gynecol] Abstract

Stem Cells Isolated from Human Dental Pulp and Amniotic Fluid Improve Skeletal Muscle Histopathology in Mdx/SCID Mice
Scientists investigated the potential of human dental pulp stem cells and human amniotic fluid stem cells to differentiate toward a skeletal myogenic lineage in order to determine the optimal conditions for achieving myogenic commitment. [Stem Cell Res Ther] Full Article

Human Amniotic Mesenchymal Stromal Cells (hAMSCs) as Potential Vehicles for Drug Delivery in Cancer Therapy: An In Vitro Study
Researchers investigated mesenchymal stromal cells isolated from the amniotic membrane of human term placenta as candidates for drug delivery in vitro. [Stem Cell Res Ther] Full Article

Repeated Autologous Umbilical Cord Blood Infusions Are Feasible and Had No Acute Safety Issues in Young Babies with Congenital Hydrocephalus
Investigators established the safety and feasibility of repeated intravenous infusions of autologous umbilical cord blood in young babies with congenital hydrocephalus. [Pediatr Res] Abstract

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The Hematopoietic System in the Context of Regenerative Medicine
The authors review the remarkable potential hematopoietic stem cells possess, and highlight their tremendous value as therapeutics in regenerative medicine. [Methods] Abstract

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Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue to Successfully Treat Non-Healing Surgical Wound
Riordan-McKenna Institute founders, stem cell expert Neil Riordan, PhD and orthopedic surgeon, Wade McKenna, DO, announced that the use of sterile, dehydrated amniotic tissue AlphaPATCH™ developed by Amniotic Therapies resulted in complete healing of an otherwise non-healing surgical knee wound. [Riordan-McKenna Institute LLC.] Press Release

MD Anderson Cancer Center and Cellectis Announce a Broad Preclinical and Clinical Strategic Alliance in Cancer Immunotherapy
Cellectis and The University of Texas MD Anderson Cancer Center have entered into a research and development alliance aimed at bringing novel cellular immunotherapies to patients suffering from different types of liquid tumors. [MD Anderson Cancer Center] Press Release

NIH Awards Nearly $34 Million to UAB Center for Clinical and Translational Science
The National Institutes of Health (NIH) has awarded the University of Alabama at Birmingham (UAB) Center for Clinical and Translational Science $33.59 million over four years to continue the center’s programs advancing translational research. [University of Alabama at Birmingham] Press Release

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NEW Director of Research – Oncology and Hematology (CancerCare Manitoba)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Assistant Member – Cord Blood (Fred Hutchinson Cancer Research Center)

Laboratory Technologist – Cord Blood and Cord Tissue Bank (Texas Stem Cell)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

Research Associate – Cell Biology (Editas Medicine)

Independent Junior Group Leader – Lymphopoiesis or Gene Regulation/Nuclear Architecture in the Hematopoietic System (Max-Planck-Institute)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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