Volume 7.35 | Sep 10

Cord Blood News 7.35 September 10, 2015
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Hierarchical Scaffolds Enhance Osteogenic Differentiation of Human Wharton’s Jelly Derived Stem Cells
In order to assess if a hierarchical structure, with nanoscale details incorporated, is an improved scaffold for bone tissue regeneration, investigators evaluated cell adhesion, proliferation, and osteogenic differentiation of human Wharton’s jelly derived stem cells, seeded into hierarchical fibrous scaffolds. [Biofabrication] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
miR-17 Promotes Expansion and Adhesion of Human Cord Blood CD34+ Cells In Vitro
Scientists demonstrated that the proper level of miR-17 is also necessary in the cell-intrinsic control of the hematopoietic properties of cord blood CD34+ cells. [Stem Cell Res Ther] Full Article

In Vitro Cardiomyocyte Differentiation of Umbilical Cord Blood Cells: Crucial Role for C-Kit+ Cells
Researchers showed that umbilical cord blood contains progenitors endowed with differentiation potential into cardiomyocytes: these cells reside in the c-kit+ fraction and require the presence of abundant accessory cells to accomplish the differentiation. [Cytotherapy] Abstract

Migrational Changes of Mesenchymal Stem Cells in Response to Cytokines, Growth Factors, Hypoxia, and Aging
Researchers showed that the inflammatory cytokines, chemokines, and growth factors TNF-α, SDF-1, PDGF, and bFGF enhance migration of rat mesenchymal stem cells (MSCs) under normoxic conditions, while TNF-α, IFN-γ, PDGF, and bFGF promote MSC migration under hypoxic conditions. Migration in MSCs from aged, human donors did not statistically differ compared to migration in MSCs derived from human umbilical cord tissue or younger donors. [Exp Cell Res] Abstract

The Impact of Fetal and Maternal Physiologic Factors on Umbilical Cord Blood Quality as a Source of Stem Cells in Egyptian Population
Scientists measured the expression of hematopoietic stem cells in umbilical cord blood (UCB) and its relation to certain maternal and neonatal physiologic factors to establish optimum criteria for UCB donor selection. [Transfusion] Abstract

Comparative Studies of Mesenchymal Stem Cells Derived from Different Cord Tissue Compartments – the Influence of Cryopreservation and Growth Media
The authors performed comparative studies with respect to the characteristics of mesenchymal stem cells isolated from different compartments of the same umbilical cord tissue such as Wharton’s jelly, vein, arteries, before cryopreservation and after cryopreservation. [Placenta] Abstract

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Improve Functional Recovery through Thrombospondin1, Pantraxin3, and Vascular Endothelial Growth Factor in the Ischemic Rat Brain
Human umbilical cord blood (hUCB)-derived mesenchymal stem cells (MSCs) were directly administered ipsilaterally into an ischemic zone induced by middle cerebral artery occlusion. They found that the neurobehavioral performance of the hUCB-MSC group was significantly improved compared with that of the vehicle-injected control group. [J Neurosci Res] Abstract

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REVIEWS
Advances in Understanding the Acute Lymphoblastic Leukemia Bone Marrow Microenvironment: From Biology to Therapeutic Targeting
The authors focus on the cellular and molecular biology of microenvironment/leukemia interactions in acute lymphoblastic leukemia of both B- and T-cell lineage. They highlight the emerging role of exosomes/microvesicles as efficient messengers for cell-to-cell communication in leukemia settings. [Biochim Biophys Acta] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
INDUSTRY NEWS
U.S. FDA Grants Priority Review to Takeda’s Ixazomib for Patients with Relapsed/Refractory Multiple Myeloma
Takeda Pharmaceutical Company Limited announced that the U.S. Food and Drug Administration (FDA) has granted priority review status to the new drug application for ixazomib, the first investigational oral proteasome inhibitor for the treatment of patients with relapsed and/or refractory multiple myeloma. [Takeda Pharmaceutical Company Limited] Press Release

Seattle Genetics Completes Enrollment in Phase III ALCANZA Clinical Trial Evaluating ADCETRIS® (Brentuximab Vedotin) in CD30-Expressing Cutaneous T-Cell Lymphoma (CTCL)
Seattle Genetics, Inc. announced that the company and its collaborator, Takeda Pharmaceutical Company Limited, completed patient enrollment in the Phase III ALCANZA clinical trial. ALCANZA is a randomized trial evaluating ADCETRIS versus investigator’s choice of methotrexate or bexarotene in 132 patients with CD30-expressing CTCL who received prior systemic therapy. [Seattle Genetics, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW AABB Annual Meeting
October 24-27, 2015
Anaheim, United States

NEW 57th American Society of Hematology (ASH) Annual Meeting
December 5-8, 2015
Orlando, United States

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Director of Research – Oncology and Hematology (CancerCare Manitoba)

Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Assistant Member – Cord Blood (Fred Hutchinson Cancer Research Center)

Laboratory Technologist – Cord Blood and Cord Tissue Bank (Texas Stem Cell)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

Research Associate – Cell Biology (Editas Medicine)

Independent Junior Group Leader – Lymphopoiesis or Gene Regulation/Nuclear Architecture in the Hematopoietic System (Max-Planck-Institute)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)


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